protein

FERRITINH

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FERRITINH: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

11Connections

0Hypotheses

0Analyses

3Outgoing

8Incoming

0Experiments

0Debates

Summary

Ferritin Heavy Chain (FTH1)

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🔬 Protein Info

Gene Symbol	FERRITINH
Function	1. Removes toxic free iron that catalyzes Fenton reactions
Molecular Weight	21 kDa
Pathways	LABILE_IRON_POOL
GeneCards	FERRITINH
Human Protein Atlas	FERRITINH
Four-helix bundle	The central structural motif containing the ferroxidase center
Ferroxidase center	Binds two iron atoms and catalyzes Fe2+ oxidation
Long loop	Connects helices B and C, involved in subunit interactions
C-terminal E-helix	Contributes to inner cavity iron nucleation sites
Associated Diseases	neurodegeneration
KG Connections	11 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Ferritin Heavy Chain (FTH1)

protein · 773 words

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Pathway Diagram

graph TD
    FERRITINH(["FERRITINH"])
    style FERRITINH fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff
    HSPA8["HSPA8"]
    LABILE_IRON_POOL(["LABILE_IRON_POOL"])
    BRAIN["BRAIN"]
    PCBP1["PCBP1"]
    ACONITASE1(["ACONITASE1"])
    PI3K(["PI3K"])
    CD63["CD63"]
    ACONITASE2(["ACONITASE2"])
    H2O2(["H2O2"])
    HEPCIDIN(["HEPCIDIN"])
    neurodegeneration["neurodegeneration"]

    FERRITINH -->|"binds"| HSPA8
    FERRITINH -->|"regulates"| LABILE_IRON_POOL
    FERRITINH -->|"expressed_in"| BRAIN
    PCBP1 -->|"binds"| FERRITINH
    ACONITASE1 -->|"regulates"| FERRITINH
    PI3K -->|"regulates"| FERRITINH
    CD63 -->|"associated_with"| FERRITINH
    PCBP1 -->|"regulates"| FERRITINH
    ACONITASE2 -->|"regulates"| FERRITINH
    H2O2 -->|"regulates"| FERRITINH
    HEPCIDIN -->|"regulates"| FERRITINH
    FERRITINH -->|"implicated_in"| neurodegeneration

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    classDef drug fill:#1a2a2a,stroke:#80cbc4,color:#e0e0e0
    class HSPA8 gene
    class LABILE_IRON_POOL protein
    class BRAIN protein
    class PCBP1 gene
    class ACONITASE1 protein
    class PI3K protein
    class CD63 gene
    class ACONITASE2 protein
    class H2O2 protein
    class HEPCIDIN protein
    class neurodegeneration disease

Outgoing (3)

Target	Relation	Type	Str
HSPA8	binds	protein	0.80
LABILE_IRON_POOL	regulates	process	0.80
BRAIN	expressed_in	brain_region	0.80

Incoming (8)

Source	Relation	Type	Str
PI3K	regulates	pathway	0.80
ACONITASE1	regulates	protein	0.80
CD63	associated_with	protein	0.80
PCBP1	binds	protein	0.80
ACONITASE2	regulates	protein	0.70
PCBP1	regulates	protein	0.70
H2O2	regulates	chemical	0.70
HEPCIDIN	regulates	protein	0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning FERRITINH in their description or question text

No additional research found