cell_type

GABAergic neurons

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GABAergic neurons: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

75Connections

0Hypotheses

0Analyses

5Outgoing

50Incoming

0Experiments

0Debates

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🧫 Cell Type Info

Cell Type	GABAergic neurons
Definition	<table class="infobox infobox-cell">
Key Markers	SST, BDNF, PVALB, APP, GABA, RNA, GABRA1, DRD2
Key Pathways	unfolded protein response, synaptic plasticity, glutamate signaling
Associated Diseases	Alzheimer's disease, epilepsy, anxiety, neurodegeneration, neuroinflammation, autism
Linked Hypotheses	41 hypotheses

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

GABAergic Neurons

cell · 1263 words

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Pathway Diagram

graph TD
    GABAergic_neurons["GABAergic neurons"] -->|"mediates"| Sleep_Restoration["Sleep Restoration"]
    style Sleep_Restoration fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    GABAergic_neurons["GABAergic neurons"] -->|"protects against"| Alzheimer_s_Disease["Alzheimer's Disease"]
    style Alzheimer_s_Disease fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    GABAergic_neurons["GABAergic neurons"] -->|"regulates"| neurodegeneration["neurodegeneration"]
    style neurodegeneration fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Alzheimer_s_disease["Alzheimer's disease"] -->|"affects"| GABAergic_neurons["GABAergic neurons"]
    style Alzheimer_s_disease fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    SST["SST"] -->|"associated"| GABAergic_neurons["GABAergic neurons"]
    style SST fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    PVALB["PVALB"] -->|"associated"| GABAergic_neurons["GABAergic neurons"]
    style PVALB fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    epilepsy["epilepsy"] -->|"affects"| GABAergic_neurons["GABAergic neurons"]
    style epilepsy fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    anxiety["anxiety"] -->|"affects"| GABAergic_neurons["GABAergic neurons"]
    style anxiety fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    style GABAergic_neurons fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (5)

Target	Relation	Type	Str
Fragile X-Associated Tremor/Ataxia Syndrome	involved_in	disease	0.90
Fragile X-associated tremor/ataxia syndrome	implicated_in	disease	0.90
Sleep Restoration	mediates	process	0.90
Alzheimer's Disease	decreases_risk	disease	0.80
neurodegeneration	regulates	disease	0.60

Incoming (70)

Source	Relation	Type	Str
CGG repeat expansion	causes	compound	0.85
Expanded Cgg Repeats	causes	variant	0.85
SST	associated_with	gene	0.80
PVALB	associated_with	gene	0.80
PRKCG	expressed_in	gene	0.80
Alzheimer's disease	affects	disease	0.80
SST	expressed_in	gene	0.80
RNA	expressed_in	gene	0.70
GABA	expressed_in	gene	0.70
epilepsy	affects	disease	0.70
anxiety	affects	disease	0.70
BDNF	regulates	gene	0.70
RNA	regulates	gene	0.60
GABA	biomarker_for	gene	0.60
glycine	released_by	neurotransmitter	0.60
MMP9	expressed_in	gene	0.60
MMP9	transported_by	gene	0.60
BDNF	implicated_in	gene	0.60
BDNF	activates	gene	0.60
DRD2	associated_with	gene	0.60
GABRA1	associated_with	gene	0.60
synaptic plasticity	active_in	pathway	0.60
PVALB	regulates	gene	0.60
neurodegeneration	affects	disease	0.60
PVALB	biomarker_for	gene	0.60
neuroinflammation	affects	disease	0.60
unfolded protein response	active_in	pathway	0.60
autism	affects	disease	0.60
APP	expressed_in	gene	0.60
RORB	expressed_in	gene	0.60
LAMP5	expressed_in	gene	0.60
GAD1	expressed_in	gene	0.60
SLC6A2	expressed_in	gene	0.60
CACNA1H	expressed_in	gene	0.60
GRIA1	expressed_in	gene	0.60
GABRA1	expressed_in	gene	0.60
DRD2	expressed_in	gene	0.60
CACNA1B	expressed_in	gene	0.60
DRD1	expressed_in	gene	0.60
HTR2A	expressed_in	gene	0.60
GRIK4	expressed_in	gene	0.60
SLC1A1	expressed_in	gene	0.60
GABRB2	expressed_in	gene	0.60
HTR2C	expressed_in	gene	0.60
depression	affects	disease	0.60
GRM5	expressed_in	gene	0.60
GABA	inhibits	gene	0.60
AMPK	regulates	gene	0.60
GDNF	expressed_in	gene	0.60
AMPK	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GABAergic neurons in their description or question text

No additional research found