biomarker 1,507 words KG: GABA
Contents

GABA (Gamma-Aminobutyric Acid) - Neurodegenerative Disease Biomarker

🔬 Protein Info
Gene SymbolGABA
Chromosome12p12.3
Functionis a hallmark of neurodegeneration.
Primary Expressionhippocampus, cortex, cerebellum, thalamus, hypothalamus
Amino Acids602 aa
Exons14
PathwaysGABAergic Signaling
GeneCardsGABA
Human Protein AtlasGABA
GABA_A receptorsLigand-gated chloride channels mediating fast inhibitory signaling
GABA_B receptorsG-protein coupled receptors mediating slow, prolonged inhibition
Associated DiseasesAls, Alzheimer, Alzheimer's disease
Known Drugs/Compoundsrapamycin
InteractionsABCA7, ACTB, Actin, Akt, AKT, AKT1
KG Connections1370 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Related Hypotheses (38)

Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.90
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.78
Prefrontal sensory gating circuit restoration via PV interne
Score: 0.78
SASP-Mediated Cholinergic Synapse Disruption
Score: 0.76
Circadian Clock-Autophagy Synchronization
Score: 0.76
Multi-Modal Stress Response Harmonization
Score: 0.76
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.75
Circadian-Synchronized Proteostasis Enhancement
Score: 0.74
APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74
Adenosine-Astrocyte Metabolic Reset
Score: 0.73
Phase-Separated Organelle Targeting
Score: 0.73
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Proteostasis Enhancement via APOE Chaperone Targeting
Score: 0.72
Sleep Spindle-Synaptic Plasticity Enhancement
Score: 0.72
Circadian Glymphatic Rescue Therapy (Melatonin-focused)
Score: 0.71
Noradrenergic-Tau Propagation Blockade
Score: 0.71
HDAC3-Selective Inhibition for Clock Reset
Score: 0.71
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Related Analyses (30)

APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived

Related Experiments (19)

Experiment Validation: In vitro ThT Assay
validation · proposed · Score: 0.40
Metabolic Pathway-Targeted Therapy in ALS
clinical · proposed · Score: 0.40
Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Experiment: Autoimmune Hypothesis Testing in AD
clinical · proposed · Score: 0.40
Regulated Necrosis Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40

See Also (8)

acetylcholine
general · KG edge: co_discussed
ACTB Gene
gene · KG edge: associated_with
adra2b Gene
gene · KG edge: expressed_in
AKT1 Gene
gene · KG edge: interacts_with
Gene Page: ALS4 (SENATAXIN)
gene · KG edge: activates

Knowledge Graph (12 edges)

GABA associated_with MTOR
GABA associated_with TFEB
AKT associated_with GABA
BACE1 associated_with GABA
TAU associated_with GABA
GABA associated_with neuroinflammation
GABA associated_with serotonin
GABA associated_with GABAergic neurons
GABA interacts_with GABARAP
FLCN interacts_with GABA

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