therapeutic

riluzole

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about riluzole: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

36Connections

0Hypotheses

0Analyses

18Outgoing

18Incoming

0Experiments

0Debates

Summary

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💊 Therapeutic Info

Name	riluzole
Key Genes/Proteins	ALS, AQP4, BDNF, MAO, PLIN2, TREK-1
Related Diseases	Alzheimer's disease
Related Pathways	neurotrophin signaling

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

riluzole

therapeutic · 1577 words

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Pathway Diagram

flowchart TD
    riluzole["riluzole"]
    ALS("ALS")
    riluzole -->|"treats"| ALS
    riluzole -->|"targets"| ALS
    riluzole -->|"associated with"| ALS
    PLIN2(["PLIN2"])
    riluzole -->|"targets"| PLIN2
    Alzheimer_s_disease("Alzheimer's disease")
    riluzole -->|"treats"| Alzheimer_s_disease
    AQP4(["AQP4"])
    riluzole -->|"targets"| AQP4
    TREK_1(["TREK-1"])
    riluzole -->|"targets"| TREK_1
    BDNF(["BDNF"])
    riluzole -->|"targets"| BDNF
    MAO("MAO")
    riluzole -->|"targets"| MAO
    neurotrophin_signaling("neurotrophin signaling")
    riluzole -->|"modulates"| neurotrophin_signaling

    style riluzole fill:#0d47a1,stroke:#4fc3f7,stroke-width:3px,color:#fff

Outgoing (18)

Target	Relation	Type	Str
ALS	treats	disease	0.95
Amyotrophic Lateral Sclerosis	treats	disease	0.95
Als	treats	disease	0.90
ALS	targets	gene	0.80
AQP4	causes	gene	0.70
GABA	regulates	phenotype	0.65
BDNF	targets	gene	0.55
MAO	targets	gene	0.55
neurotrophin signaling	modulates	pathway	0.55
PLIN2	targets	gene	0.55
TREK-1	targets	gene	0.55
AQP4	targets	gene	0.55
Alzheimer's disease	treats	disease	0.55
BDNF	associated_with	gene	0.50
AQP4	associated_with	gene	0.50
GABA	associated_with	phenotype	0.45
NEURONS	associated_with	cell_type	0.45
TDP-43	associated_with	gene	0.45

Incoming (18)

Source	Relation	Type	Str
ALS	treats	disease	0.65
NEURONS	activates	cell_type	0.65
ASTROCYTE	associated_with	cell_type	0.50
ALZHEIMER'S DISEASE	associated_with	disease	0.50
ALZHEIMER	associated_with	disease	0.50
BRAINSTEM	associated_with	brain_region	0.50
ALS	therapeutic_target	disease	0.50
GLUTAMATE	associated_with	phenotype	0.45
INTERNEURONS	associated_with	cell_type	0.45
SPINAL CORD	associated_with	brain_region	0.45
CEREBELLUM	associated_with	brain_region	0.45
ARIMOCLOMOL	associated_with	drug	0.45
MOTOR NEURONS	associated_with	cell_type	0.45
MEMANTINE	associated_with	drug	0.45
EDARAVONE	associated_with	drug	0.45
BARICITINIB	associated_with	drug	0.45
EDARAVONE	therapeutic_target	drug	0.35
ALS	associated_with	disease	0.35

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning riluzole in their description or question text

No additional research found