protein 1,867 words KG: GABARAPPROTEIN
Contents

GABARAP Protein

🔬 Protein Info
Gene SymbolGABARAP
Full NameGABA Type A Receptor Associated Protein
Chromosome17p13.1
FunctionGABARAP is a member of the ATG8 family (MAP1LC3/GABARAP family) with multiple cellular functions
Subcellular Localization</strong></td><td>Cytosolic, membrane-associated</td></tr>
PathwaysAkt, Autophagy, Endocytosis, Er Stress, Lysosomal Degradation
UniProt IDO95166
NCBI Gene ID23710
Ensembl IDENSG00000138967
OMIM607418
GeneCardsGABARAP
Human Protein AtlasGABARAP
N-terminal Helical DomainContains an ubiquitin-like fold (β-grasp fold)
C-terminal GlycineRequired for lipidation at phosphatidylethanolamine
Hydrophobic PocketBinds microtubule-associated proteins and autophagy receptors
Associated DiseasesAls, Alzheimer, Amyotrophic Lateral Sclerosis, Ataxia, Cancer
Known Drugs/Compoundsrapamycin
InteractionsActin, AKT1, AKT1S1, AMBRA1, AMPK, AMYLOID
KG Connections969 knowledge graph edges
DatabasesGeneCardsHPASTRING

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