concept

SEROTONIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SEROTONIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

221Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	SEROTONIN
Key Genes/Proteins	AKT, ALZHEIMER, AMYLOID, ANXIETY, APOE, BDNF
Related Diseases	acetylcholine, aging, Alzheimer'S Disease, ALZHEIMER'S DISEASE, ATP

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Serotonin Neurons

cell · 608 words

→

Pathway Diagram

graph TD
    SEROTONIN["SEROTONIN"]
    style SEROTONIN fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    SEROTONIN -.->|"protects against"| Depression["Depression"]
    SEROTONIN -->|"regulates"| NEURONAL_PLASTICITY["NEURONAL PLASTICITY"]
    SEROTONIN -->|"modulates"| GAPDH([GAPDH])
    SEROTONIN -->|"regulates"| Neuronal_Plasticity["Neuronal Plasticity"]
    SEROTONIN -->|"modulates"| SERT([SERT])
    SEROTONIN -->|"involved_in"| Hippocampus_Dependent_Learning["Hippocampus-Dependent Learning"]
    SEROTONIN -->|"regulates"| Neuronal_Maturation["Neuronal Maturation"]
    Exercise["Exercise"] -->|"upregulates"| SEROTONIN
    AADC["AADC"] -->|"catalyzes"| SEROTONIN
    Tryptophan["Tryptophan"] -->|"interacts"| SEROTONIN
    SSRIs{"SSRIs"} -->|"targets"| SEROTONIN
    Circadian_Clock_Genes["Circadian Clock Genes"] -->|"regulates"| SEROTONIN
    SERT -->|"regulates"| SEROTONIN
    exercise["exercise"] -->|"activates"| SEROTONIN
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"regulates"| SEROTONIN
    AMYLOID([AMYLOID]) -->|"activates"| SEROTONIN

Outgoing (70)

Target	Relation	Type	Str
Neuroplasticity	modulates	process	0.95
Alzheimer's Disease	associated_with	disease	0.95
Depression	protects_against	disease	0.92
Anxiety	regulates	phenotype	0.90
neurons	released_by	cell_type	0.90
GAPDH	modulates	protein	0.90
Sleep	regulates	phenotype	0.90
DEPRESSION	associated_with	entity	0.90
NEURONAL PLASTICITY	regulates	entity	0.90
ALZHEIMER'S DISEASE	associated_with	entity	0.85
SERT	modulates	protein	0.85
Neuronal Plasticity	involved_in	process	0.85
Sleep Regulation	regulates	process	0.85
Posttranslational Modifications	involved_in	process	0.85
Neuronal Survival	promotes	process	0.85
Major Depressive Disorder	contributes_to	disease	0.85
Neuronal Plasticity	regulates	process	0.85
Neuronal Differentiation	promotes	process	0.80
Insomnia	involved_in	disease	0.80
SERT	interacts_with	protein	0.80
Gut-Brain Axis	component_of	mechanism	0.80
PRKN	modulates	protein	0.80
PINK1	modulates	protein	0.80
Hippocampus-Dependent Learning	involved_in	process	0.80
hippocampus	active_in	brain_region	0.80
Depression	associated_with	disease	0.80
Neuronal Maturation	regulates	process	0.80
Sleep-Wake Cycle	regulates	process	0.80
Schizophrenia	associated_with	disease	0.80
Autism	associated_with	disease	0.80
Depression	involved_in	disease	0.80
Cell Migration	promotes	process	0.75
Neuronal Differentiation	regulates	phenotype	0.75
Dopamine Synthesis	modulates	process	0.75
Prkaca	activates	protein	0.75
Sepsis-Associated Encephalopathy	modulates	disease	0.75
thalamus	active_in	brain_region	0.70
hypothalamus	active_in	brain_region	0.70
Alzheimer's Disease	implicated_in	disease	0.70
cortex	active_in	brain_region	0.70
Hepatocellular Carcinoma	modulates	disease	0.70
prefrontal cortex	active_in	brain_region	0.70
MELATONIN	causes	drug	0.70
NEURONS	produces	cell_type	0.70
MITOCHONDRIAL DYSFUNCTION	exacerbates	phenotype	0.65
DEPRESSION	increases_risk	disease	0.65
FLUOXETINE	inhibits	drug	0.65
MITOPHAGY	regulates	phenotype	0.65
MITOPHAGY	interacts_with	phenotype	0.65
ALZHEIMER'S DISEASE	targets	disease	0.65

Incoming (151)

Source	Relation	Type	Str
Exercise	upregulates	process	0.95
Tryptophan	mediates	compound	0.95
Tryptophan	interacts_with	compound	0.90
Tryptophan	activates	compound	0.90
ALZHEIMER'S DISEASE	associated_with	disease	0.90
depression	disrupts	disease	0.90
serotonin receptor	binds	receptor	0.90
ADHD	associated_with	disease	0.90
SSRIs	targets	drug	0.90
Circadian Clock Genes	regulates	pathway	0.85
SERT	regulates	protein	0.85
Peganum Harmala	upregulates	drug	0.85
schizophrenia	disrupts	disease	0.80
sleep disorders	disrupts	disease	0.80
Hippocampal Volume	associated_with	biomarker	0.80
GABA	associated_with	gene	0.80
Alzheimer's disease	disrupts	disease	0.80
AADC	associated_with	gene	0.80
neuroinflammation	disrupts	disease	0.80
BDNF	associated_with	gene	0.74
PARKINSON'S DISEASE	associated_with	disease	0.74
CRH	releases	gene	0.70
anxiety	disrupts	disease	0.70
exercise	activates	process	0.70
IL-6	associated_with	gene	0.66
PI3K	associated_with	gene	0.66
AMYLOID	associated_with	protein	0.66
AKT	associated_with	gene	0.66
NEURONS	causes	cell_type	0.65
KYNURENINE PATHWAY	activates	pathway	0.65
TAU	regulates	protein	0.65
NEUROINFLAMMATION	causes	phenotype	0.65
ATP	inhibits	phenotype	0.65
TLR4	activates	gene	0.60
obesity	disrupts	disease	0.60
IFN	associated_with	gene	0.60
multiple sclerosis	disrupts	disease	0.60
ERK	regulates	gene	0.60
GABA	modulates	gene	0.60
autism	disrupts	disease	0.60
TGM2	associated_with	gene	0.60
GBM	inhibits	gene	0.60
GBM	treats	gene	0.60
NAMPT	associated_with	gene	0.60
HTT	associated_with	gene	0.60
HTT	causes	gene	0.60
HTT	transported_by	gene	0.60
HTT	activates	gene	0.60
diabetes	disrupts	disease	0.60
BDNF	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity