concept

EXCITOTOXICITY

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about EXCITOTOXICITY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

350Connections

2Hypotheses

4Analyses

50Outgoing

50Incoming

0Experiments

6Debates

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💡 Concept Info

Name	EXCITOTOXICITY
Key Genes/Proteins	AKT, ALZHEIMER, AMPK, AMYLOID, AMYLOID-BETA, amyotrophic lateral sclerosis
Related Diseases	ALS, Alzheimer'S Disease, ALZHEIMER'S DISEASE, AMYOTROPHIC LATERAL SCLEROSIS

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Excitotoxicity in Neurodegeneration

mechanism · 4129 words

→

Pathway Diagram

graph TD
    EXCITOTOXICITY["EXCITOTOXICITY"]
    EXCITOTOXICITY -->|"causes"| Neurotoxicity["Neurotoxicity"]
    EXCITOTOXICITY -->|"causes"| STIM1["STIM1"]
    EXCITOTOXICITY -->|"causes"| NEURODEGENERATION["NEURODEGENERATION"]
    EXCITOTOXICITY -->|"inhibits"| FOXO3["FOXO3"]
    EXCITOTOXICITY -->|"activates"| NEURON["NEURON"]
    EXCITOTOXICITY -->|"activates"| STING["STING"]
    EXCITOTOXICITY -->|"promotes"| HIPPOCAMPUS["HIPPOCAMPUS"]
    EXCITOTOXICITY -->|"promotes"| OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    EXCITOTOXICITY -->|"regulates"| MITOCHONDRIAL_DYSFUNCTION["MITOCHONDRIAL DYSFUNCTION"]
    glutamate_receptors["glutamate receptors"] -->|"causes"| EXCITOTOXICITY
    Glutamate["Glutamate"] -->|"causes"| EXCITOTOXICITY
    Glutamate_receptors["Glutamate receptors"] -->|"mediates"| EXCITOTOXICITY
    NAD_metabolism["NAD metabolism"] -->|"participates in"| EXCITOTOXICITY
    GLUTAMATE["GLUTAMATE"] -->|"causes"| EXCITOTOXICITY
    glutamate["glutamate"] -->|"causes"| EXCITOTOXICITY
    ginsenosides["ginsenosides"] -->|"inhibits"| EXCITOTOXICITY
    inflammation["inflammation"] -->|"causes"| EXCITOTOXICITY
    GLUTAMATE_RECEPTORS["GLUTAMATE_RECEPTORS"] -->|"causes"| EXCITOTOXICITY

Outgoing (159)

Target	Relation	Type	Str
Ischemic Stroke	contributes_to	disease	0.90
Neurotoxicity	causes	process	0.90
Calcium Overload	associated_with	process	0.90
Motor Neuron Death	causes	process	0.90
Stroke	contributes_to	disease	0.90
Motor Neuron Degeneration	contributes_to	phenotype	0.85
Amyotrophic lateral sclerosis	associated_with	disease	0.70
Ferroptosis	activates	pathway	0.70
motor neuron death	causes	phenotype	0.70
ERK	regulates	gene	0.70
CELL DEATH	activates	phenotype	0.70
FERROPTOSIS	inhibits	phenotype	0.65
FERROPTOSIS	causes	phenotype	0.65
FERROPTOSIS	activates	phenotype	0.65
AMPK	activates	gene	0.65
NECROPTOSIS	activates	phenotype	0.65
FERROPTOSIS	targets	phenotype	0.65
UBIQUITIN	degrades	protein	0.65
AXONAL DEGENERATION	activates	phenotype	0.65
NECROPTOSIS	regulates	phenotype	0.65
STIM1	causes	protein	0.64
oxidative stress	regulates	process	0.60
neuroinflammation	associated_with	process	0.60
TRKB	associated_with	gene	0.60
MIRO1	associated_with	gene	0.60
STIM1	activates	gene	0.60
SST	activates	gene	0.60
HK2	activates	gene	0.55
SPINAL CORD	associated_with	brain_region	0.55
PARKINSON'S DISEASE	participates_in	disease	0.55
TET2	activates	gene	0.55
VGLUT1	inhibits	gene	0.55
TFEB	activates	gene	0.55
ULK1	activates	gene	0.55
LOCUS COERULEUS	co_discussed	entity	0.50
OLIGODENDROCYTE	co_discussed	entity	0.50
OLIGODENDROCYTES	co_discussed	entity	0.50
MS	co_discussed	entity	0.50
Proteins	inhibits	protein	0.50
RIPK1	co_discussed	entity	0.50
RIPK3	co_discussed	entity	0.50
OXIDATIVE STRESS	co_discussed	entity	0.50
Neurodegeneration	associated_with	disease	0.50
Alzheimer's Disease	associated_with	disease	0.50
Parkinson's Disease	associated_with	disease	0.50
CORTEX	associated_with	brain_region	0.50
HUNTINGTON	co_discussed	entity	0.50
MITOPHAGY	co_discussed	entity	0.50
SOD1	co_discussed	entity	0.50
GLUTAMATE	co_discussed	entity	0.50

Incoming (191)

Source	Relation	Type	Str
NPY	protects_against	protein	0.95
39602529	were neuroprotective against	paper	0.90
Glutamate	causes	entity	0.90
Glutamate receptors	mediates	receptor	0.90
41302199	is a convergent hallmark of	paper	0.90
glutamate receptors	causes	protein	0.90
Oligodendrocyte	mediates	cell_type	0.90
Astrocyte	mediates	cell_type	0.90
Astrocytes	contributes_to	cell_type	0.85
CYTOKINES	associated_with	protein	0.85
Glutamate Receptor Accumulation	causes	mechanism	0.85
Glutamate Receptor Accumulation	contributes_to	process	0.85
HMGCR	inhibits	gene	0.80
NAD metabolism	participates_in	process	0.80
SOD1	mediates	protein	0.80
NPY	alleviates	gene	0.80
GLUTAMATE	causes	drug	0.72
SYNAPTIC PLASTICITY	causes	phenotype	0.70
glutamate	causes	protein	0.70
inflammation	causes	process	0.70
SLC7A11	causes	protein	0.70
ginsenosides	inhibits	drug	0.70
system xC-	causes	protein	0.70
GABA	protects_against	phenotype	0.70
GABA	inhibits	phenotype	0.70
TREM2 upregulation in DAM cells	causes	mechanism	0.70
VGLUT1 terminals	vulnerable_to	cell_type	0.70
NPTX2 downregulation	causes	mechanism	0.70
glutamate_receptors	causes	protein	0.68
GLUTAMATE_RECEPTORS	causes	protein	0.68
ASTROCYTE	causes	cell_type	0.65
STROKE	causes	disease	0.65
KYNURENINE PATHWAY	activates	pathway	0.65
ASTROCYTES	exacerbates	cell_type	0.65
ROS	inhibits	phenotype	0.65
BDNF	activates	gene	0.65
LOCUS COERULEUS	causes	brain_region	0.65
ALZHEIMER'S DISEASE	implicated_in	disease	0.65
SLC1A3	protects_against	gene	0.60
SLC1A2	protects_against	gene	0.60
ALZHEIMER'S DISEASE	activates	disease	0.58
AKT	activates	gene	0.58
GLUTAMATE	associated_with	phenotype	0.55
autophagy	activates	pathway	0.55
GABA	expressed_in	phenotype	0.55
PARKINSON'S	associated_with	concept	0.50
ABETA	co_discussed	entity	0.50
CORTEX	co_discussed	entity	0.50
ASTROCYTE	co_discussed	entity	0.50
BDNF	co_discussed	entity	0.50

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Subtle NMDAR Inhibition Attenuates Excitotoxicity-Driven Tau	0.620	neurodegeneration	Investigate prion-like spreading of tau
Synaptic NMDAR Subtype Targeting Prevents Excitotoxicity	0.520	neurodegeneration	Test Preregistration Analysis