gene 646 words KG: DNM1L
Contents

DNM1L Gene

🧬 Gene Info
Gene SymbolDNM1L
Full NameDynamin 1 Like (Dynamin-Related Protein 1)
Chromosome12p11.21
FunctionDRP1 orchestrates mitochondrial fission
Primary Expressionastrocytes and microglia
PathwaysApoptosis, Mitochondrial Function, Mitophagy, Oxidative Stress
UniProt ID[O00429](https://www.uniprot.org/uniprot/O00429)
Ensembl IDENSG00000087470
GeneCardsDNM1L
Human Protein AtlasDNM1L
Associated DiseasesAD, Aging, ALI, Als, Alzheimer
Known Drugs/Compoundsmetformin, rapamycin
InteractionsABCD3, ADORA2A, AIF1, AKT, ALS, ALZHEIMER
KG Connections965 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (25)

Adenosine-Astrocyte Metabolic Reset
Score: 0.73
AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.82
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Senescent Cell Mitochondrial DNA Release
Score: 0.74
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.74
SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK
Score: 0.74
CYP46A1 Overexpression Gene Therapy
Score: 0.73
Phase-Separated Organelle Targeting
Score: 0.73
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Stress Granule Phase Separation Modulators
Score: 0.72
Autophagosome Maturation Checkpoint Control
Score: 0.71
Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70
Mitochondrial Transfer Pathway Enhancement
Score: 0.70
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
CX43 hemichannel engineering enables size-selective mitochon
Score: 0.69
RAB27A-dependent extracellular vesicle engineering for mitoc
Score: 0.67
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.67
GAP43-mediated tunneling nanotube stabilization enhances neu
Score: 0.67
RNA Granule Nucleation Site Modulation
Score: 0.66
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Related Analyses (9)

Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived

See Also (11)

AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
ABCD3 Gene
gene · KG edge: interacts_with
ADORA2A Gene
gene · KG edge: interacts_with
AIF1 Gene
gene · KG edge: activates
AMBRA1 Gene
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

CAT interacts_with DNM1L
OPTN interacts_with DNM1L
DNM1L interacts_with CANX
DNM1L interacts_with LGALS3
DNM1L interacts_with CALCOCO2
DNM1L interacts_with G3BP1
DNM1L interacts_with PEX3
DNM1L interacts_with SQSTM1
DNM1L interacts_with BCL2
DNM1L interacts_with LMNA

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