concept

PRKAA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PRKAA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

144Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

PRKAA is a concept in neurodegeneration research. Key relationships include: activates, associated with, inhibits. Associated with ALS, Alzheimer, Cancer. Connected to 56 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

💡 Concept Info

Name	PRKAA
Key Genes/Proteins	ACTB, ALZHEIMER, ALZHEIMER DISEASE, AMPK, AND, APOPTOSIS
Related Diseases	ALS, Alzheimer, Alzheimer Disease, Alzheimer's disease
Related Pathways	Apoptosis, Autophagy

Wiki Pages (2)

Knowledge base pages for this entity

PRKAA2 (AMPKα2) — AMP-Activated Protein Kinase Catalytic Subunit Alpha 2

gene · 1883 words

→

PRKAA1

gene · 1355 words

→

Pathway Diagram

graph TD
    PRKAA["PRKAA"]
    PRKAA -->|"inhibits"| MTORC1["MTORC1"]
    PRKAA -->|"activates"| TFEB["TFEB"]
    PRKAA -->|"inhibits"| MTOR["MTOR"]
    PRKAA -->|"inhibits"| RPS6KB1["RPS6KB1"]
    PRKAA -->|"activates"| PINK1["PINK1"]
    PRKAA -->|"activates"| PRKN["PRKN"]
    PRKAA -->|"activates"| DNM1L["DNM1L"]
    PRKAA -->|"activates"| MFF["MFF"]
    PRKAA -->|"activates"| Alzheimer["Alzheimer"]
    PRKAA -->|"activates"| Neurodegeneration["Neurodegeneration"]
    TXNIP["TXNIP"] -->|"interacts"| PRKAA
    DMSO["DMSO"] -->|"activates"| PRKAA
    ATG7["ATG7"] -->|"activates"| PRKAA
    AUTOPHAGY["AUTOPHAGY"] -->|"activates"| PRKAA
    LYSOSOMAL_BIOGENESIS["LYSOSOMAL BIOGENESIS"] -->|"activates"| PRKAA
    JUN["JUN"] -->|"activates"| PRKAA
    ACTB["ACTB"] -->|"activates"| PRKAA
    SLC7A11["SLC7A11"] -->|"activates"| PRKAA
    DES["DES"] -->|"activates"| PRKAA

Outgoing (66)

Target	Relation	Type	Str
MTOR	inhibits	gene	0.90
TFEB	activates	gene	0.90
RPS6KB1	inhibits	gene	0.90
MTORC1	inhibits	protein	0.90
MFF	activates	gene	0.80
DNM1L	activates	gene	0.80
PINK1	activates	gene	0.80
PRKN	activates	gene	0.80
Neurodegeneration	activates	disease	0.65
Cancer	activates	disease	0.65
Ischemia	activates	disease	0.65
Alzheimer	activates	disease	0.65
ALS	activates	disease	0.65
Tumor	activates	disease	0.65
CTSB	associated_with	gene	0.60
NEURODEGENERATION	activates	gene	0.60
LYSOSOME	activates	gene	0.60
Mtor	associated_with	pathway	0.60
Autophagy	activates	pathway	0.60
CANCER	activates	gene	0.60
BECN1	activates	gene	0.60
SLC7A11	activates	gene	0.60
ferroptosis	participates_in	pathway	0.60
SOX9	activates	gene	0.60
ULK1	activates	gene	0.60
VIM	activates	gene	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
PARKIN	associated_with	gene	0.60
MFF	associated_with	gene	0.60
DRP1	associated_with	gene	0.60
PINK1	associated_with	gene	0.60
DNM1L	associated_with	gene	0.60
Necroptosis	activates	pathway	0.60
Ferroptosis	activates	pathway	0.60
Apoptosis	activates	pathway	0.60
ferroptosis	activates	process	0.60
ROS	activates	gene	0.60
RELA	activates	gene	0.60
AND	activates	gene	0.60
Rb	activates	protein	0.60
Fus	activates	protein	0.60
RNA	activates	gene	0.60
SNAP25	activates	gene	0.60
SQSTM1	activates	gene	0.60
SYN1	activates	gene	0.60
SYT1	activates	gene	0.60
TUBB3	activates	gene	0.60
Alzheimer's disease	activates	disease	0.60
oxidative stress response	participates_in	pathway	0.60
autophagy pathway	participates_in	pathway	0.60

Incoming (78)

Source	Relation	Type	Str
TXNIP	interacts_with	protein	0.90
TXNIP	regulates	protein	0.90
SLC7A11	activates	gene	0.60
DES	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
FERROPTOSIS	activates	gene	0.60
AMPK	activates	gene	0.60
DMSO	activates	gene	0.60
P62	associated_with	gene	0.60
MAP1LC3B	associated_with	gene	0.60
TUBB3	associated_with	gene	0.60
CTSD	associated_with	gene	0.60
LC3	associated_with	gene	0.60
ATG7	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
SYN1	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
LYSOSOMAL BIOGENESIS	activates	gene	0.60
SYT1	associated_with	gene	0.60
JUN	activates	gene	0.60
ACTB	activates	gene	0.60
PRKN	associated_with	gene	0.60
AMPK	associated_with	gene	0.60
AND	associated_with	gene	0.60
BDNF	associated_with	gene	0.60
LAMP1	associated_with	gene	0.60
NEURODEGENERATION	activates	gene	0.60
TUBULIN	associated_with	gene	0.60
LYSOSOME	activates	gene	0.60
CTSB	associated_with	gene	0.60
RNA	associated_with	gene	0.60
NEURODEGENERATIVE DISORDERS	activates	gene	0.60
MAP2	associated_with	gene	0.60
SNAP25	associated_with	gene	0.60
GENES	associated_with	gene	0.60
ALZHEIMER DISEASE	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
TFEB	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
MET	activates	gene	0.60
LC3	activates	gene	0.60
MTOR	activates	gene	0.60
rapamycin	targets	drug	0.60
PIKFYVE	activates	gene	0.60
AND	activates	gene	0.60
MTORC1	activates	gene	0.60
CANCER	activates	gene	0.60
EIF4EBP1	activates	gene	0.60
GFP	activates	gene	0.60
GUSB	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PRKAA in their description or question text

No additional research found