Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CSF1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
CSF1 is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, associated with. Associated with Aging, Als, Alzheimer. Connected to 94 entities in the SciDEX knowledge graph.
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| Gene Symbol | CSF1 |
| Chromosome | 1p13.3 |
| Function | is a disulfide-bonded homodimer of approximately 60 kDa. |
| Primary Expression | neurons[@wang2018] |
| Molecular Weight | 60 kDa |
| Amino Acids | 554 aa |
| Exons | 11 |
| Pathways | PI3K, MAPK |
| Ensembl ID | ENSG00000184371 |
| GeneCards | CSF1 |
| Human Protein Atlas | CSF1 |
| Isoform 1 (canonical) | 554 amino acids, secreted soluble protein |
| Isoform 2 | Truncated, membrane-bound form |
| Isoform 3 | Alternative start site variant |
| N-terminal signal peptide | Directs secretion |
| Associated Diseases | Melanoma, multiple sclerosis, Tumor |
| Interactions | ACTB, AGING, AKT, AMPK, AND, APOPTOSIS |
| KG Connections | 158 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
CSF1["CSF1"]
Cancer{"Cancer"}
CSF1 -->|"activates"| Cancer
Als{"Als"}
CSF1 -->|"activates"| Als
Senescence{"Senescence"}
CSF1 -->|"therapeutic target"| Senescence
Glioblastoma{"Glioblastoma"}
CSF1 -->|"therapeutic target"| Glioblastoma
Tumor{"Tumor"}
CSF1 -->|"activates"| Tumor
Ms{"Ms"}
CSF1 -->|"activates"| Ms
Aging{"Aging"}
CSF1 -->|"activates"| Aging
Carcinoma{"Carcinoma"}
CSF1 -->|"activates"| Carcinoma
BAX["BAX"]
CSF1 -->|"activates"| BAX
DDX58["DDX58"]
CSF1 -->|"activates"| DDX58
STAT1["STAT1"]
CSF1 -->|"activates"| STAT1
BNIP3L["BNIP3L"]
CSF1 -->|"activates"| BNIP3L
STAT1 -->|"activates"| CSF1
DDX58 -->|"activates"| CSF1
BAX -->|"activates"| CSF1
AGING["AGING"]
AGING -->|"activates"| CSF1
SOX2["SOX2"]
SOX2 -->|"activates"| CSF1
ATF2["ATF2"]
ATF2 -->|"activates"| CSF1
HNRNPU["HNRNPU"]
HNRNPU -->|"activates"| CSF1
MYC["MYC"]
MYC -->|"activates"| CSF1
style CSF1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Ferroptosis | mediates | process | 0.80 |
| Inflammation | regulates | disease | 0.75 |
| Neuroinflammation | regulates | disease | 0.75 |
| ASTROCYTE | regulates | gene | 0.70 |
| NEUROINFLAMMATION | regulates | gene | 0.70 |
| macrophages | expressed_in | cell_type | 0.70 |
| neurons | expressed_in | cell_type | 0.70 |
| oxidative stress response | participates_in | pathway | 0.70 |
| Melanoma | associated_with | disease | 0.65 |
| Infection | activates | disease | 0.65 |
| Multiple Sclerosis | activates | disease | 0.65 |
| Bacterial Infection | activates | disease | 0.65 |
| Neuroinflammation | activates | disease | 0.65 |
| Inflammation | activates | disease | 0.65 |
| Tumor | associated_with | disease | 0.65 |
| ALS | activates | disease | 0.65 |
| Carcinoma | activates | disease | 0.65 |
| Necroptosis | activates | disease | 0.65 |
| Stroke | activates | disease | 0.65 |
| Pyroptosis | activates | disease | 0.65 |
| Ferroptosis | activates | disease | 0.65 |
| Tumor | activates | disease | 0.65 |
| Ms | activates | disease | 0.65 |
| Neurodegeneration | regulates | disease | 0.65 |
| Alzheimer | regulates | disease | 0.65 |
| Cancer | activates | disease | 0.65 |
| Senescence | therapeutic_target | disease | 0.65 |
| Als | activates | disease | 0.65 |
| Glioblastoma | therapeutic_target | disease | 0.65 |
| Glioblastoma | regulates | disease | 0.65 |
| Aging | activates | disease | 0.65 |
| Glioma | regulates | disease | 0.65 |
| Cancer | regulates | disease | 0.65 |
| FGF1 | activates | gene | 0.60 |
| FGFR2 | activates | gene | 0.60 |
| Epigenetic | activates | pathway | 0.60 |
| Mitochondrial Function | activates | pathway | 0.60 |
| ALZHEIMER | regulates | gene | 0.60 |
| GENES | regulates | gene | 0.60 |
| CCL2 | activates | gene | 0.60 |
| CANCER | regulates | gene | 0.60 |
| ASTROCYTES | regulates | gene | 0.60 |
| GLIOBLASTOMA | regulates | gene | 0.60 |
| ULK1 | activates | gene | 0.60 |
| AKT | activates | gene | 0.60 |
| CSF1R | expressed_in | gene | 0.60 |
| CXCL1 | interacts_with | gene | 0.60 |
| Cholesterol | regulates | pathway | 0.60 |
| NOTCH2 | regulates | gene | 0.60 |
| ferroptosis | participates_in | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| PHF2 | regulates | enzyme | 0.95 |
| CCL2 | interacts_with | gene | 0.60 |
| CCL2 | expressed_in | gene | 0.60 |
| HNRNPU | activates | gene | 0.60 |
| MYC | activates | gene | 0.60 |
| LCN2 | activates | gene | 0.60 |
| GENES | activates | gene | 0.60 |
| OLIGODENDROCYTE | activates | gene | 0.60 |
| RNA | activates | gene | 0.60 |
| FERROPTOSIS | activates | gene | 0.60 |
| MICROGLIA | activates | gene | 0.60 |
| TNFRSF1A | regulates | gene | 0.60 |
| STAT3 | regulates | gene | 0.60 |
| NFKBIA | regulates | gene | 0.60 |
| AGING | activates | gene | 0.60 |
| INFLAMMATION | activates | gene | 0.60 |
| TLR | associated_with | gene | 0.60 |
| AUTOPHAGY | activates | gene | 0.60 |
| LYSOSOME | activates | gene | 0.60 |
| NEURODEGENERATION | regulates | gene | 0.60 |
| STAT1 | activates | gene | 0.60 |
| ASC | associated_with | gene | 0.60 |
| AIM2 | associated_with | gene | 0.60 |
| SQSTM1 | associated_with | gene | 0.60 |
| VAMP8 | associated_with | gene | 0.60 |
| ULK1 | associated_with | gene | 0.60 |
| CTSB | associated_with | gene | 0.60 |
| ATP6V0D1 | associated_with | gene | 0.60 |
| NLRP3 | associated_with | gene | 0.60 |
| ACTB | activates | gene | 0.60 |
| IL6 | associated_with | gene | 0.60 |
| LC3 | associated_with | gene | 0.60 |
| LAMP1 | associated_with | gene | 0.60 |
| PYCARD | associated_with | gene | 0.60 |
| P62 | associated_with | gene | 0.60 |
| SNAP29 | associated_with | gene | 0.60 |
| ATG14 | activates | gene | 0.60 |
| CASP1 | associated_with | gene | 0.60 |
| TNF | associated_with | gene | 0.60 |
| IL1B | associated_with | gene | 0.60 |
| ATG16L1 | activates | gene | 0.60 |
| PYROPTOSIS | activates | gene | 0.60 |
| STROKE | activates | gene | 0.60 |
| APOPTOSIS | activates | gene | 0.60 |
| DDX58 | activates | gene | 0.60 |
| BAX | activates | gene | 0.60 |
| SOX2 | activates | gene | 0.60 |
| ATF2 | activates | gene | 0.60 |
| AMPK | activates | gene | 0.60 |
| microglia | activates | cell_type | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| CSF1R-TREM2 Co-Agonism for Sustained Microglial Expansion | 0.808 | neurodegeneration | TREM2 agonism vs antagonism in DAM micro |
| TREM2-CSF1R Cross-Talk in Microglial Metabolic Reprogramming | 0.748 | neurodegeneration | Gene expression changes in aging mouse b |
| CSF1R Inhibition-Mediated Microglial Replacement as a State | 0.581 | neurodegeneration | How do different microglial subtypes (DA |
| CSF1R Partial Agonism Combined with TREM2 Activation for ALS | 0.535 | neurodegeneration | Microglial subtypes in neurodegeneration |
| TREM2 on Perivascular Macrophages Senses Aβ and Drives SPP1 | 0.496 | neurodegeneration | How do perivascular cells specifically r |
| CSF1R Inhibition Reversal Window Depends on Microglia Replac | 0.395 | neurodegeneration | What is the optimal therapeutic window f |
| Microglial Phenotypic Polarization via CSF1R-Mediated Metabo | 0.380 | developmental neurobiology | Do perinatal immune challenges create pe |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-04 | 0 hypotheses
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Dynamics and Impact of Repopulating Microglia Following Oligodendroglial Damage. [PMID:41645884] | Di Pietro AA, Thomas L, Pasquini LA | J Neurochem | 2026 | 0 |
| Temporal modulation of microglial repopulation attenuates retinal degeneration i [PMID:41690604] | Zhang W, Bian B, Ren C | Neurobiol Dis | 2026 | 0 |
| The impact of CSF1R inhibitor-mediated microglial depletion in rodent models of [PMID:41822299] | Ferreira AFF, Santos-Silva AC, Muratori | Front Aging Neurosci | 2026 | 0 |
| Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] | ["Chen Kai", "Li Fuyao", "Zhang Shuwen", | Journal of neuroinflammation | 2025 | 0 |
| Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] | ["Chen Kai", "Li Fuyao", "Zhang Shuwen", | Journal of neuroinflammation | 2025 | 0 |
| CSF1R inhibition rescues tau pathology and neurodegeneration in an A/T/N model w [PMID:34103079] | ["Lodder Chritica", "Scheyltjens Isabell | Acta neuropathologica communic | 2021 | 0 |
| Don't know what you got till it's gone: microglial depletion and neurodegenerati [PMID:33642360] | ["Graykowski David", "Cudaback Eiron"] | Neural regeneration research | 2021 | 0 |
| Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554] | Marogianni C, Sokratous M, Dardiotis E, | International journal of molec | 2020 | 0 |
| Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554] | Marogianni C, Sokratous M, Dardiotis E, | International journal of molec | 2020 | 0 |
| Microglial Depletion with CSF1R Inhibitor During Chronic Phase of Experimental T [PMID:32094203] | ["Henry Rebecca J", "Ritzel Rodney M", " | The Journal of neuroscience : | 2020 | 0 |
| Multiple Sclerosis Pathology. [PMID:29358320] | Lassmann H | Cold Spring Harbor perspective | 2018 | 0 |
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning CSF1 in their description or question text
Score: 0.395 · neurodegeneration · 2026-04-22
## Mechanistic Overview CSF1R Inhibition Reversal Window Depends on Microglia Replacement Kinetics starts from the claim
Score: 0.380 · developmental neurobiology · 2026-04-27
The molecular foundation of microglial phenotypic polarization during perinatal immune activation centers on colony-stim