gene

CSF1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CSF1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

158Connections
7Hypotheses
1Analyses
50Outgoing
50Incoming
0Experiments
1Debates

Summary

CSF1 is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, associated with. Associated with Aging, Als, Alzheimer. Connected to 94 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolCSF1
Chromosome1p13.3
Functionis a disulfide-bonded homodimer of approximately 60 kDa.
Primary Expressionneurons[@wang2018]
Molecular Weight60 kDa
Amino Acids554 aa
Exons11
PathwaysPI3K, MAPK
Ensembl IDENSG00000184371
GeneCardsCSF1
Human Protein AtlasCSF1
Isoform 1 (canonical)554 amino acids, secreted soluble protein
Isoform 2Truncated, membrane-bound form
Isoform 3Alternative start site variant
N-terminal signal peptideDirects secretion
Associated DiseasesMelanoma, multiple sclerosis, Tumor
InteractionsACTB, AGING, AKT, AMPK, AND, APOPTOSIS
KG Connections158 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (12)

Knowledge base pages for this entity

Canonical Page

csf1

gene · 1653 words

CSF1R Inhibitors for Parkinson's Disease

therapeutic · 3030 words

CSF1R-Targeted Microglia Therapy

idea · 2114 words

Pexidartinib (PLX3397) CSF1R Inhibitor Parkinson's Disease Trial (NCT04888966)

clinical · 1930 words

CSF1R Modulation Therapy: Microglia Reset Protocol

idea · 1879 words

CSF1R Inhibitors for Neurodegeneration

therapeutic · 1808 words

Pathway Diagram

graph TD
    CSF1["CSF1"]
    Cancer{"Cancer"}
    CSF1 -->|"activates"| Cancer
    Als{"Als"}
    CSF1 -->|"activates"| Als
    Senescence{"Senescence"}
    CSF1 -->|"therapeutic target"| Senescence
    Glioblastoma{"Glioblastoma"}
    CSF1 -->|"therapeutic target"| Glioblastoma
    Tumor{"Tumor"}
    CSF1 -->|"activates"| Tumor
    Ms{"Ms"}
    CSF1 -->|"activates"| Ms
    Aging{"Aging"}
    CSF1 -->|"activates"| Aging
    Carcinoma{"Carcinoma"}
    CSF1 -->|"activates"| Carcinoma
    BAX["BAX"]
    CSF1 -->|"activates"| BAX
    DDX58["DDX58"]
    CSF1 -->|"activates"| DDX58
    STAT1["STAT1"]
    CSF1 -->|"activates"| STAT1
    BNIP3L["BNIP3L"]
    CSF1 -->|"activates"| BNIP3L
    STAT1 -->|"activates"| CSF1
    DDX58 -->|"activates"| CSF1
    BAX -->|"activates"| CSF1
    AGING["AGING"]
    AGING -->|"activates"| CSF1
    SOX2["SOX2"]
    SOX2 -->|"activates"| CSF1
    ATF2["ATF2"]
    ATF2 -->|"activates"| CSF1
    HNRNPU["HNRNPU"]
    HNRNPU -->|"activates"| CSF1
    MYC["MYC"]
    MYC -->|"activates"| CSF1
    style CSF1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (107)

TargetRelationTypeStr
Ferroptosismediatesprocess0.80
Inflammationregulatesdisease0.75
Neuroinflammationregulatesdisease0.75
ASTROCYTEregulatesgene0.70
NEUROINFLAMMATIONregulatesgene0.70

Incoming (51)

SourceRelationTypeStr
PHF2regulatesenzyme0.95
CCL2interacts_withgene0.60
CCL2expressed_ingene0.60
HNRNPUactivatesgene0.60
MYCactivatesgene0.60

Targeting Hypotheses (7)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
CSF1R-TREM2 Co-Agonism for Sustained Microglial Expansion 0.808 neurodegeneration TREM2 agonism vs antagonism in DAM micro
TREM2-CSF1R Cross-Talk in Microglial Metabolic Reprogramming 0.748 neurodegeneration Gene expression changes in aging mouse b
CSF1R Inhibition-Mediated Microglial Replacement as a State 0.581 neurodegeneration How do different microglial subtypes (DA
CSF1R Partial Agonism Combined with TREM2 Activation for ALS 0.535 neurodegeneration Microglial subtypes in neurodegeneration
TREM2 on Perivascular Macrophages Senses Aβ and Drives SPP1 0.496 neurodegeneration How do perivascular cells specifically r
CSF1R Inhibition Reversal Window Depends on Microglia Replac 0.395 neurodegeneration What is the optimal therapeutic window f
Microglial Phenotypic Polarization via CSF1R-Mediated Metabo 0.380 developmental neurobiology Do perinatal immune challenges create pe

Mentioning Analyses (1)

Scientific analyses that reference this entity

Neuroinflammation and microglial priming in early Alzheimer's Disease

neurodegeneration | 2026-04-04 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

ExperimentTypeDiseaseScoreFeasibilityModelStatusEst. Cost
No experiments found

Related Papers (11)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
Dynamics and Impact of Repopulating Microglia Following Oligodendroglial Damage. [PMID:41645884] Di Pietro AA, Thomas L, Pasquini LA J Neurochem 2026 0
Temporal modulation of microglial repopulation attenuates retinal degeneration i [PMID:41690604] Zhang W, Bian B, Ren C Neurobiol Dis 2026 0
The impact of CSF1R inhibitor-mediated microglial depletion in rodent models of [PMID:41822299] Ferreira AFF, Santos-Silva AC, Muratori Front Aging Neurosci 2026 0
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] ["Chen Kai", "Li Fuyao", "Zhang Shuwen", Journal of neuroinflammation 2025 0
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] ["Chen Kai", "Li Fuyao", "Zhang Shuwen", Journal of neuroinflammation 2025 0
CSF1R inhibition rescues tau pathology and neurodegeneration in an A/T/N model w [PMID:34103079] ["Lodder Chritica", "Scheyltjens Isabell Acta neuropathologica communic 2021 0
Don't know what you got till it's gone: microglial depletion and neurodegenerati [PMID:33642360] ["Graykowski David", "Cudaback Eiron"] Neural regeneration research 2021 0
Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554] Marogianni C, Sokratous M, Dardiotis E, International journal of molec 2020 0
Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554] Marogianni C, Sokratous M, Dardiotis E, International journal of molec 2020 0
Microglial Depletion with CSF1R Inhibitor During Chronic Phase of Experimental T [PMID:32094203] ["Henry Rebecca J", "Ritzel Rodney M", " The Journal of neuroscience : 2020 0
Multiple Sclerosis Pathology. [PMID:29358320] Lassmann H Cold Spring Harbor perspective 2018 0

Debates (1)

Multi-agent debates referencing this entity

Neuroinflammation and microglial priming in early Alzheimer's Disease

closed · Rounds: 3 · Score: 0.95 · 2026-04-04

Related Research

Hypotheses and analyses mentioning CSF1 in their description or question text

CSF1R Inhibition Reversal Window Depends on Microglia Replacement Kinetics

Score: 0.395 · neurodegeneration · 2026-04-22

## Mechanistic Overview CSF1R Inhibition Reversal Window Depends on Microglia Replacement Kinetics starts from the claim

Microglial Phenotypic Polarization via CSF1R-Mediated Metabolic Reprogramming

Score: 0.380 · developmental neurobiology · 2026-04-27

The molecular foundation of microglial phenotypic polarization during perinatal immune activation centers on colony-stim