gene 1,653 words KG: CSF1
Contents

CSF1 Gene

🧬 Gene Info
Gene SymbolCSF1
Chromosome1p13.3
Functionis a disulfide-bonded homodimer of approximately 60 kDa.
Primary Expressionneurons[@wang2018]
Molecular Weight60 kDa
Amino Acids554 aa
Exons11
PathwaysPI3K, MAPK
Ensembl IDENSG00000184371
GeneCardsCSF1
Human Protein AtlasCSF1
Isoform 1 (canonical)554 amino acids, secreted soluble protein
Isoform 2Truncated, membrane-bound form
Isoform 3Alternative start site variant
N-terminal signal peptideDirects secretion
Associated DiseasesMelanoma, multiple sclerosis, Tumor
InteractionsACTB, AGING, AKT, AMPK, AND, APOPTOSIS
KG Connections158 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (25)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Prefrontal sensory gating circuit restoration via PV interne
Score: 0.78
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
APOE-TREM2 Interaction Modulation
Score: 0.74
PARP1 Inhibition Therapy
Score: 0.74
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.72
Autophagosome Maturation Checkpoint Control
Score: 0.71
Microglial Efferocytosis Enhancement via GPR32 Superagonists
Score: 0.70
Microglial Purinergic Reprogramming
Score: 0.70
Lysosomal Positioning Dynamics Modulation
Score: 0.69
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
Context-Dependent CRISPR Activation in Specific Neuronal Sub
Score: 0.68
Complement C1q Subtype Switching
Score: 0.66
RNA Granule Nucleation Site Modulation
Score: 0.66
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58
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Related Analyses (16)

Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived

See Also (15)

Astrocytes
cell · KG edge: regulates
AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
Apoptosis in Neurodegeneration
entity · KG edge: activates
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: activates
ABCA1 - ATP-Binding Cassette Transporter A1
gene · KG edge: regulates

Knowledge Graph (12 edges)

STAT1 activates CSF1
CSF1 activates BAX
CSF1 activates DDX58
DDX58 activates CSF1
BAX activates CSF1
CSF1 activates STAT1
SOX2 activates CSF1
ATF2 activates CSF1
CSF1 activates BNIP3L
CSF1 activates NEAT1

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