gene

FGFR1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FGFR1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

230Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

Page for FGFR1 — Fibroblast Growth Factor Receptor 1

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🧬 Gene Info

Gene Symbol	FGFR1
Full Name	Fibroblast Growth Factor Receptor 1
Chromosome	8p11
Function	FGFR1 encodes fibroblast growth factor receptor 1, a receptor tyrosine kinase that binds multiple FGF ligands (FGF1, FGF2, FGF4, etc.).
Primary Expression	neural stem cells, neurons, and astrocytes
Pathways	MAPK, PI3K
UniProt ID	[P11362](https://www.uniprot.org/uniprot/P11362)
Ensembl ID	ENSG00000077782
OMIM	136350
GeneCards	FGFR1
Human Protein Atlas	FGFR1
Associated Diseases	Als, Cancer, epilepsy, Glioblastoma
Interactions	AGING, AKT, AKT3, AMPK, AND, APOPTOSIS
KG Connections	230 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

FGFR1 — Fibroblast Growth Factor Receptor 1

gene · 528 words

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Pathway Diagram

graph TD
    FGFR1["FGFR1"]
    adipogenesis["adipogenesis"]
    FGFR1 -->|"activates"| adipogenesis
    KLB["KLB"]
    FGFR1 -->|"interacts with"| KLB
    Hypertension{"Hypertension"}
    FGFR1 -->|"inhibits"| Hypertension
    Ms{"Ms"}
    FGFR1 -->|"inhibits"| Ms
    Als{"Als"}
    FGFR1 -->|"inhibits"| Als
    Inflammation{"Inflammation"}
    FGFR1 -->|"activates"| Inflammation
    Obesity{"Obesity"}
    FGFR1 -->|"activates"| Obesity
    Carcinoma{"Carcinoma"}
    FGFR1 -->|"therapeutic target"| Carcinoma
    Cancer{"Cancer"}
    FGFR1 -->|"therapeutic target"| Cancer
    Tumor{"Tumor"}
    FGFR1 -->|"therapeutic target"| Tumor
    Diabetes{"Diabetes"}
    FGFR1 -->|"activates"| Diabetes
    Neuroinflammation{"Neuroinflammation"}
    FGFR1 -->|"activates"| Neuroinflammation
    FGF1["FGF1"]
    FGF1 -->|"activates"| FGFR1
    FGF21["FGF21"]
    FGF21 -->|"interacts with"| FGFR1
    HSPG2["HSPG2"]
    HSPG2 -->|"activates"| FGFR1
    FGF1 -->|"regulates"| FGFR1
    FGF21 -->|"protects against"| FGFR1
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    PARKINSON_S_DISEASE -->|"activates"| FGFR1
    MICROGLIA["MICROGLIA"]
    MICROGLIA -->|"activates"| FGFR1
    SIRT1["SIRT1"]
    SIRT1 -->|"protects against"| FGFR1
    APOPTOSIS["APOPTOSIS"]
    APOPTOSIS -->|"activates"| FGFR1
    AUTOPHAGY["AUTOPHAGY"]
    AUTOPHAGY -->|"activates"| FGFR1
    CDK1["CDK1"]
    CDK1 -->|"activates"| FGFR1
    OTUD4["OTUD4"]
    OTUD4 -->|"activates"| FGFR1
    style FGFR1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (154)

Target	Relation	Type	Str
adipogenesis	activates	phenotype	0.80
Cancer	activates	disease	0.75
Tumor	activates	disease	0.75
limbal stem cells	expressed_in	cell_type	0.75
KLB	interacts_with	protein	0.70
Glioblastoma	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Als	causes	disease	0.65
Neuroinflammation	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Glioblastoma	activates	disease	0.65
Ms	inhibits	disease	0.65
Als	inhibits	disease	0.65
Prostate Cancer	inhibits	disease	0.65
Als	activates	disease	0.65
Carcinoma	activates	disease	0.65
Tumor	biomarker_for	disease	0.65
Inflammation	activates	disease	0.65
Hypertension	inhibits	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Als	associated_with	disease	0.65
Epilepsy	associated_with	disease	0.65
Cancer	therapeutic_target	disease	0.65
Tumor	therapeutic_target	disease	0.65
Parkinson	activates	disease	0.65
Ms	associated_with	disease	0.65
Obesity	activates	disease	0.65
Diabetes	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Aging	activates	disease	0.65
Ms	activates	disease	0.65
ALS	associated_with	disease	0.65
Tumor	associated_with	disease	0.65
NFKB2	regulates	gene	0.60
NOTCH2	regulates	gene	0.60
FGFR2	biomarker_for	gene	0.60
GLUT4	activates	gene	0.60
AMPK	activates	gene	0.60
Synaptic Plasticity	activates	pathway	0.60
TP53	activates	gene	0.60
Rb	inhibits	protein	0.60
Mapk	activates	pathway	0.60
GENES	regulates	gene	0.60
ASTROCYTE	regulates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
NEUROINFLAMMATION	regulates	gene	0.60
MICROGLIA	regulates	gene	0.60
Notch	regulates	pathway	0.60

Incoming (76)

Source	Relation	Type	Str
PHF2	regulates	enzyme	0.95
VEGF-B	binds_to	protein	0.95
FGF1	activates	protein	0.90
FGF21	interacts_with	protein	0.70
ACETYLCHOLINE	causes	phenotype	0.65
CYTOKINES	regulates	phenotype	0.65
CYTOKINES	inhibits	phenotype	0.65
AUTOPHAGY	activates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
GLUT4	activates	gene	0.60
PARKINSON'S DISEASE	activates	gene	0.60
MICROGLIA	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
STAT3	regulates	gene	0.60
NFKBIA	regulates	gene	0.60
CSF1	regulates	gene	0.60
IL6ST	regulates	gene	0.60
SOD1	activates	gene	0.60
SOD2	activates	gene	0.60
NURR1	activates	gene	0.60
FGF21	protects_against	gene	0.60
CDK1	activates	gene	0.60
OTUD4	activates	gene	0.60
GBM	activates	gene	0.60
PTEN	activates	gene	0.60
TNF	activates	gene	0.60
FGF9	inhibits	gene	0.60
TNFRSF1A	regulates	gene	0.60
RNA	activates	gene	0.60
HSPG2	activates	gene	0.60
FGF1	regulates	gene	0.60
SIRT1	protects_against	gene	0.60
AND	activates	gene	0.60
NF1	associated_with	gene	0.60
DYRK1A	associated_with	gene	0.60
AKT3	associated_with	gene	0.60
PIK3CA	associated_with	gene	0.60
PTEN	associated_with	gene	0.60
EGFR	associated_with	gene	0.60
BRAF	associated_with	gene	0.60
RHEB	associated_with	gene	0.60
NRAS	associated_with	gene	0.60
PARKINSON	activates	gene	0.60
AGING	activates	gene	0.60
FGF2	expressed_in	gene	0.60
FGF9	expressed_in	gene	0.60
CANCER	activates	gene	0.60
ALZHEIMER	regulates	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
AMPK	activates	entity	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning FGFR1 in their description or question text

No additional research found