gene 1,481 words KG: CSF1R
Contents

CSF1R — Colony Stimulating Factor 1 Receptor

🧬 Gene Info
Gene SymbolCSF1R
Full NameColony Stimulating Factor 1 Receptor
Chromosome5q32
Protein TypeReceptor
FunctionUpon ligand binding, CSF1R undergoes
Primary ExpressionMicroglia, Macrophages, Osteoclasts, Placenta
Molecular Weight107.6 kDa
Amino Acids972 aa
PathwaysPI3K
UniProt IDP07333
NCBI Gene ID1436
Ensembl IDENSG00000182578
OMIM164770
GeneCardsCSF1R
Human Protein AtlasCSF1R
Associated DiseasesAls, Alzheimer, Anxiety, Atherosclerosis, cancer
Known Drugs/Compoundsdasatinib, KETAMINE, nicotinamide, NICOTINAMIDE, PLX3397, PLX5622
InteractionsABL1, ABL2, ACHE, ACT001, Actin, AD
SciDEX HypothesesCSF1R Inhibition-Mediated Microglial Replacement a
KG Connections700 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (30)

TREM2-Dependent Microglial Senescence Transition
Score: 0.95
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.84
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.78

Related Analyses (26)

Neuroinflammation and microglial priming in early Alzheimer'
neurodegeneration · archived
TREM2 agonism vs antagonism in DAM microglia
neurodegeneration · completed
Gene expression changes in aging mouse brain predicting neur
neurodegeneration · completed
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived

Related Experiments (4)

Proposed experiment from debate on Synaptic pruning by micro
falsification · proposed · Score: 0.40
FTD Microglia Role: Protective vs Destructive Mechanism Stud
validation · proposed · Score: 0.40
Cytochrome Therapeutics
clinical · proposed · Score: 0.40
TREM2 Function in Alzheimer's Disease — From Risk Variant to
validation · proposed · Score: 0.45

See Also (7)

AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: activates
AIF1 Gene
gene · KG edge: associated_with
ATG7 Gene
gene · KG edge: expressed_in
Alzheimer Indonesia
institution · KG edge: activates

Knowledge Graph (12 edges)

CSF1R activates STAT5
TYK2 contributes_to CSF1R
PTK2B contributes_to CSF1R
IL7R contributes_to CSF1R
JAK2 activates CSF1R
PDGFRB activates CSF1R
NTRK3 contributes_to CSF1R
PLX3397 inhibits CSF1R
CSF1R contributes_to TYK2
NRBP1 inhibits CSF1R

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