Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about HNRNPU: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
HNRNPU (Heterogeneous Nuclear Ribonucleoprotein U) encodes a nuclear matrix protein essential for RNA processing, chromatin organization, and is implicated in ALS and other neurodegenerative diseases.
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| Gene Symbol | HNRNPU |
| Aliases | Heterogeneous Nuclear Ribonucleoprotein U |
| Chromosome | 1q44. |
| Function | is a ubiquitously expressed nuclear matrix protein encoded by the HNRNPU gene located on chromosome 1q44. |
| Molecular Weight | 825 kDa |
| Amino Acids | 724 aa |
| Exons | 28 |
| Pathways | Epigenetic, Nf-Κb |
| GeneCards | HNRNPU |
| Human Protein Atlas | HNRNPU |
| Associated Diseases | Alzheimer's disease, Parkinson's disease, ALS |
| Interactions | AND, CANCER, CCL2, CSF1, CSF1R, CTCF |
| KG Connections | 28 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
HNRNPU["HNRNPU"]
Carcinoma{"Carcinoma"}
HNRNPU -->|"activates"| Carcinoma
Ms{"Ms"}
HNRNPU -->|"activates"| Ms
Cancer{"Cancer"}
HNRNPU -->|"activates"| Cancer
Tumor{"Tumor"}
HNRNPU -->|"activates"| Tumor
MYC["MYC"]
HNRNPU -->|"activates"| MYC
CSF1["CSF1"]
HNRNPU -->|"activates"| CSF1
CANCER["CANCER"]
HNRNPU -->|"activates"| CANCER
CTCF["CTCF"]
HNRNPU -->|"interacts with"| CTCF
EP300["EP300"]
HNRNPU -->|"interacts with"| EP300
IGF2BP2["IGF2BP2"]
HNRNPU -->|"interacts with"| IGF2BP2
CSF1R["CSF1R"]
HNRNPU -->|"activates"| CSF1R
Epigenetic(["Epigenetic"])
HNRNPU -->|"activates"| Epigenetic
style HNRNPU fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| IκBα | interacts_with | protein | 0.88 |
| Ms | activates | disease | 0.65 |
| Cancer | activates | disease | 0.65 |
| Inflammation | phosphorylates | disease | 0.65 |
| Tumor | activates | disease | 0.65 |
| Carcinoma | activates | disease | 0.65 |
| Infection | activates | disease | 0.65 |
| Inflammation | activates | disease | 0.65 |
| Nf-Κb | activates | pathway | 0.60 |
| CSF1 | activates | gene | 0.60 |
| CTCF | interacts_with | gene | 0.60 |
| MYC | activates | gene | 0.60 |
| IGF2BP2 | interacts_with | gene | 0.60 |
| CSF1R | activates | gene | 0.60 |
| EP300 | interacts_with | gene | 0.60 |
| CANCER | activates | gene | 0.60 |
| P38 | activates | gene | 0.60 |
| Epigenetic | activates | pathway | 0.60 |
| AND | activates | gene | 0.60 |
| FOXN3 | activates | gene | 0.60 |
| P38 | phosphorylates | entity | 0.60 |
| IΚBΑ | activates | protein | 0.50 |
| NF-κB | activates | concept | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| FOXN3 | binds_to | protein | 0.90 |
| phosphorylated FOXN3 | inhibits | protein | 0.85 |
| FOXN3 | activates | gene | 0.60 |
| NF-ΚB | activates | gene | 0.60 |
| INFLAMMATION | activates | gene | 0.60 |
| CCL2 | activates | gene | 0.60 |
| P38 | activates | gene | 0.60 |
| INFLAMMATION | phosphorylates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning HNRNPU in their description or question text
No additional research found