gene

NFKB2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NFKB2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

29Connections

0Hypotheses

0Analyses

19Outgoing

10Incoming

0Experiments

0Debates

Summary

NFKB2 is a gene implicated in neurodegeneration research. Key relationships include: regulates, inhibits, implicated in. Associated with Als, Alzheimer, Carcinoma. Connected to 28 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	NF
Full Name	κB p100/p52 Protein
Aliases	NFKB2
Protein Family	NF-κB transcription factors
Protein Type	Transcription Factor
Function	NFKB2 encodes p100, which is processed to p52.
Molecular Weight	100 kDa
Amino Acids	900 aa
Exons	24 coding exons
Pathways	Nfkb, NFKB, NF-κB, NF-κB Pathway, NF-κB Signaling
UniProt ID	[Q12986](https://www.uniprot.org/uniprot/Q12986)
GeneCards	NF
Human Protein Atlas	NF
Transcript	~2.8 kb mRNA
Protein	900 amino acids, ~100 kDa (p100); 52 kDa (p52)
Associated Diseases	neurodegeneration
Interactions	CD4, CD8
KG Connections	29 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

NFKB2 Gene

gene · 800 words

→

NFKB2 Protein

protein · 674 words

→

Pathway Diagram

graph TD
    NFKB2["NFKB2"]
    Carcinoma{"Carcinoma"}
    NFKB2 -->|"inhibits"| Carcinoma
    Als{"Als"}
    NFKB2 -->|"inhibits"| Als
    Tumor{"Tumor"}
    NFKB2 -->|"inhibits"| Tumor
    CD8["CD8"]
    NFKB2 -->|"inhibits"| CD8
    Epigenetic(["Epigenetic"])
    NFKB2 -->|"activates"| Epigenetic
    Cholesterol(["Cholesterol"])
    NFKB2 -->|"inhibits"| Cholesterol
    neurodegeneration["neurodegeneration"]
    NFKB2 -->|"implicated in"| neurodegeneration
    CD4["CD4"]
    CD4 -->|"inhibits"| NFKB2
    style NFKB2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (19)

Target	Relation	Type	Str
IL1B	regulates	gene	0.87
Als	inhibits	disease	0.65
Inflammation	regulates	disease	0.65
Neuroinflammation	regulates	disease	0.65
Carcinoma	inhibits	disease	0.65
Alzheimer	regulates	disease	0.65
Tumor	inhibits	disease	0.65
Neurodegeneration	regulates	disease	0.65
MICROGLIA	regulates	gene	0.60
Notch	regulates	pathway	0.60
CD8	inhibits	gene	0.60
Epigenetic	regulates	pathway	0.60
NOTCH2	regulates	gene	0.60
Epigenetic	activates	pathway	0.60
Cholesterol	inhibits	pathway	0.60
GENES	regulates	gene	0.60
ASTROCYTE	regulates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
NEUROINFLAMMATION	regulates	gene	0.60

Incoming (10)

Source	Relation	Type	Str
PHF2	regulates	enzyme	0.95
NEURODEGENERATION	regulates	gene	0.60
CD4	inhibits	gene	0.60
ALZHEIMER	regulates	gene	0.60
TNFRSF1A	regulates	gene	0.60
STAT3	regulates	gene	0.60
NFKBIA	regulates	gene	0.60
CSF1	regulates	gene	0.60
IL6ST	regulates	gene	0.60
FGFR1	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NFKB2 in their description or question text

No additional research found