gene

IL6ST

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IL6ST: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

65Connections

0Hypotheses

0Analyses

39Outgoing

26Incoming

0Experiments

0Debates

Summary

Page for IL6ST - Interleukin 6 Signal Transducer (gp130)

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🧬 Gene Info

Gene Symbol	IL6ST
Full Name	Interleukin 6 Signal Transducer (gp130)
Aliases	gp130
Chromosome	5q11.2
Primary Expression	Ubiquitous (neurons, astrocytes, microglia, oligodendrocytes)
Molecular Weight	130 kDa
Amino Acids	917 aa
Exons	18
Pathways	Epigenetic, Notch
UniProt ID	P40189
NCBI Gene ID	3572
GeneCards	IL6ST
Human Protein Atlas	IL6ST
Associated Diseases	neurodegeneration
Interactions	AND, APOPTOSIS, CANCER, CREBBP, CYTOKINES, FERROPTOSIS
KG Connections	64 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: IL6ST — AlphaFold P40189 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

IL6ST - Interleukin 6 Signal Transducer (gp130)

gene · 1853 words

→

IL6 Signal Transducer (gp130/IL6ST) Protein

protein · 608 words

→

Pathway Diagram

graph TD
    IL6ST["IL6ST"]
    Ms{"Ms"}
    IL6ST -->|"therapeutic target"| Ms
    Carcinoma{"Carcinoma"}
    IL6ST -->|"interacts with"| Carcinoma
    Cancer{"Cancer"}
    IL6ST -->|"interacts with"| Cancer
    Tumor{"Tumor"}
    IL6ST -->|"interacts with"| Tumor
    Apoptosis(["Apoptosis"])
    IL6ST -->|"interacts with"| Apoptosis
    neurodegeneration["neurodegeneration"]
    IL6ST -->|"implicated in"| neurodegeneration
    __synuclein["alpha-synuclein"]
    __synuclein -->|"activates"| IL6ST
    IL6["IL6"]
    IL6 -->|"interacts with"| IL6ST
    CYTOKINES["CYTOKINES"]
    CYTOKINES -->|"interacts with"| IL6ST
    RAGE["RAGE"]
    RAGE -->|"therapeutic target"| IL6ST
    IL6R["IL6R"]
    IL6R -->|"interacts with"| IL6ST
    LRP1["LRP1"]
    LRP1 -->|"interacts with"| IL6ST
    NR3C1["NR3C1"]
    NR3C1 -->|"interacts with"| IL6ST
    GATA1["GATA1"]
    GATA1 -->|"interacts with"| IL6ST
    MYC["MYC"]
    MYC -->|"interacts with"| IL6ST
    CANCER["CANCER"]
    CANCER -->|"interacts with"| IL6ST
    APOPTOSIS["APOPTOSIS"]
    APOPTOSIS -->|"interacts with"| IL6ST
    CREBBP["CREBBP"]
    CREBBP -->|"interacts with"| IL6ST
    style IL6ST fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (39)

Target	Relation	Type	Str
Carcinoma	interacts_with	disease	0.65
Cancer	interacts_with	disease	0.65
Tumor	interacts_with	disease	0.65
Neuroinflammation	activates	disease	0.65
Parkinson	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Inflammation	activates	disease	0.65
Inflammation	regulates	disease	0.65
Neuroinflammation	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Ms	therapeutic_target	disease	0.65
AND	interacts_with	gene	0.60
CANCER	interacts_with	gene	0.60
Cell Cycle	interacts_with	pathway	0.60
APOPTOSIS	interacts_with	gene	0.60
Notch	regulates	pathway	0.60
Epigenetic	regulates	pathway	0.60
Apoptosis	interacts_with	pathway	0.60
NEUROINFLAMMATION	regulates	gene	0.60
FERROPTOSIS	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
HSPB1	activates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
MICROGLIA	activates	gene	0.60
Ferroptosis	activates	pathway	0.60
JAK2	activates	gene	0.60
FGFR1	regulates	gene	0.60
NFKB2	regulates	gene	0.60
NOTCH2	regulates	gene	0.60
MYC	interacts_with	gene	0.60
GATA1	interacts_with	gene	0.60
NR3C1	interacts_with	gene	0.60
CREBBP	interacts_with	gene	0.60
LRP1	interacts_with	gene	0.60
GENES	regulates	gene	0.60
ASTROCYTE	regulates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
MICROGLIA	regulates	gene	0.60

Incoming (26)

Source	Relation	Type	Str
PHF2	regulates	enzyme	0.95
IL6	part_of	gene	0.80
α-synuclein	activates	protein	0.70
CYTOKINES	interacts_with	gene	0.60
GENES	interacts_with	gene	0.60
IL6	interacts_with	gene	0.60
RAGE	therapeutic_target	gene	0.60
IL6R	interacts_with	gene	0.60
LRP1	interacts_with	gene	0.60
NR3C1	interacts_with	gene	0.60
GATA1	interacts_with	gene	0.60
MYC	interacts_with	gene	0.60
CREBBP	interacts_with	gene	0.60
STAT3	activates	gene	0.60
TNFRSF1A	regulates	gene	0.60
STAT3	regulates	gene	0.60
NFKBIA	regulates	gene	0.60
CSF1	regulates	gene	0.60
CANCER	interacts_with	gene	0.60
APOPTOSIS	interacts_with	gene	0.60
ALZHEIMER	regulates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
PARKINSON'S DISEASE	activates	gene	0.60
HIF	activates	gene	0.60
PARKINSON	activates	gene	0.60
NEURODEGENERATION	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning IL6ST in their description or question text

No additional research found