Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about DDX58: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
DDX58 is a gene implicated in neurodegeneration research. Key relationships include: activates, implicated in, interacts with. Associated with Als, Cancer, Glioblastoma. Connected to 21 entities in the SciDEX knowledge graph.
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| Gene Symbol | DDX58 |
| Full Name | DEAD-Box Helicase 58 |
| Chromosome | 9q34.3 |
| Protein Type | Receptor |
| Function | DDX58 (DEAD-Box Helicase 58), commonly known as RIG-I (Retinoic Acid-Inducible Gene I), is a cytoplasmic pattern recognition receptor (PRR) that detects viral RNA and initiates antiviral immune respon |
| Primary Expression | Ubiquitous, high in immune cells and brain |
| Pathways | Interferon Signaling |
| UniProt ID | [O95786](https://www.uniprot.org/uniprot/O95786) |
| GeneCards | DDX58 |
| Human Protein Atlas | DDX58 |
| RNA sensing | Recognizes 5' triphosphate double-stranded RNA and viral RNA motifs |
| Helicase activity | Unwinds RNA substrates using ATP hydrolysis |
| Signal transduction | Activates downstream signaling cascades |
| Interferon induction | Triggers type I interferon (IFN-α/β) production |
| Antiviral response | Initiates cellular antiviral defenses |
| Associated Diseases | neurodegeneration |
| Interactions | BAX, BECN1, CSF1, HNRNPA1, STAT1 |
| KG Connections | 20 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
DDX58["DDX58"]
Cancer{"Cancer"}
DDX58 -->|"activates"| Cancer
Als{"Als"}
DDX58 -->|"regulates"| Als
Senescence{"Senescence"}
DDX58 -->|"therapeutic target"| Senescence
Glioblastoma{"Glioblastoma"}
DDX58 -->|"activates"| Glioblastoma
Tumor{"Tumor"}
DDX58 -->|"activates"| Tumor
Ms{"Ms"}
DDX58 -->|"activates"| Ms
BAX["BAX"]
DDX58 -->|"activates"| BAX
CSF1["CSF1"]
DDX58 -->|"activates"| CSF1
STAT1["STAT1"]
DDX58 -->|"activates"| STAT1
neurodegeneration["neurodegeneration"]
DDX58 -->|"implicated in"| neurodegeneration
HNRNPA1["HNRNPA1"]
HNRNPA1 -->|"interacts with"| DDX58
STAT1 -->|"activates"| DDX58
CSF1 -->|"activates"| DDX58
BAX -->|"activates"| DDX58
style DDX58 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| HNRNPA1 | interacts_with | protein | 0.75 |
| Ms | activates | disease | 0.65 |
| Cancer | activates | disease | 0.65 |
| Als | regulates | disease | 0.65 |
| Senescence | therapeutic_target | disease | 0.65 |
| Glioblastoma | activates | disease | 0.65 |
| Tumor | activates | disease | 0.65 |
| Interferon Signaling | activates | pathway | 0.60 |
| BAX | activates | gene | 0.60 |
| Immune Response | implicated_in | pathway | 0.60 |
| CSF1 | activates | gene | 0.60 |
| STAT1 | activates | gene | 0.60 |
| AUTOPHAGY | implicated_in | gene | 0.60 |
| Autophagy | implicated_in | pathway | 0.60 |
| Innate Immunity | implicated_in | pathway | 0.60 |
| BECN1 | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning DDX58 in their description or question text
No additional research found