cell 604 words KG: ent-gene-16cf4081
Contents

CSF1R-Inhibited Microglia

🔬 Protein Info
Gene SymbolCSF1R
Full NameInhibited Microglia
AliasesColony Stimulating Factor 1 Receptor
Chromosome5q32
Protein TypeReceptor
FunctionUpon ligand binding, CSF1R undergoes
Primary ExpressionMicroglia, Macrophages, Osteoclasts, Placenta
Molecular Weight107.6 kDa
Amino Acids972 aa
PathwaysPI3K
UniProt IDP07333
NCBI Gene ID1436
Ensembl IDENSG00000182578
OMIM164770
GeneCardsCSF1R
Human Protein AtlasCSF1R
Associated DiseasesAls, Alzheimer, Anxiety, Atherosclerosis, cancer
Known Drugs/Compoundsdasatinib, KETAMINE, nicotinamide, NICOTINAMIDE, PLX3397, PLX5622
InteractionsABL1, ABL2, ACHE, ACT001, Actin, AD
SciDEX HypothesesCSF1R Inhibition-Mediated Microglial Replacement a
Microglial Phenotypic Polarization via CSF1R-Media
KG Connections700 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

Wikipedia

Related Hypotheses (8)

Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.79
Senescent Cell Mitochondrial DNA Release
Score: 0.74
Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.73
Orexin-Microglia Modulation Therapy
Score: 0.71
Grid Cell-Specific Metabolic Reprogramming via IDH2 Enhancem
Score: 0.65
Astrocytic Lactate Shuttle Enhancement for Grid Cell Bioener
Score: 0.53
ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.87
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76

Related Analyses (18)

Neuroinflammation and microglial priming in early Alzheimer'
neurodegeneration · archived
Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived

Related Experiments (3)

TREM2 Function in Alzheimer's Disease — From Risk Variant to
validation · proposed · Score: 0.45
Proposed experiment from debate on Synaptic pruning by micro
falsification · proposed · Score: 0.40
FTD Microglia Role: Protective vs Destructive Mechanism Stud
validation · proposed · Score: 0.40

Knowledge Graph (5 edges)

39891235 is required for ent-gene-16cf4081
h-a512eecb08 targets ent-gene-16cf4081
ent-gene-16cf4081 targeted_by h-a512eecb08
h-3685e352 targets ent-gene-16cf4081
ent-gene-16cf4081 targeted_by h-3685e352

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