concept

ACETYL-COA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ACETYL-COA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

584Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

ACETYL-COA is a concept in neurodegeneration research. Key relationships include: activates, associated with, inhibits. Associated with ALS, Aging, Als. Connected to 391 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	ACETYL-COA
Key Genes/Proteins	ACAT1, ACC, ACHE, ACLY, Actin, AGING
Related Diseases	Aging, Als, ALS, Alzheimer
Related Pathways	Akt, Alpha-Synuclein

Pathway Diagram

graph TD
    ACETYL_COA["ACETYL-COA"]
    ACETYL_COA -->|"activates"| STAT3["STAT3"]
    ACETYL_COA -->|"activates"| histone_acetylation["histone acetylation"]
    ACETYL_COA -->|"activates"| Tumor["Tumor"]
    ACETYL_COA -->|"activates"| Ms["Ms"]
    ACETYL_COA -->|"activates"| Als["Als"]
    ACETYL_COA -->|"inhibits"| Cardiovascular["Cardiovascular"]
    ACETYL_COA -->|"inhibits"| Atherosclerosis["Atherosclerosis"]
    ACETYL_COA -->|"interacts"| Alzheimer["Alzheimer"]
    AUTOPHAGY["AUTOPHAGY"] -->|"activates"| ACETYL_COA
    AMPK["AMPK"] -->|"activates"| ACETYL_COA
    BNIP3["BNIP3"] -->|"activates"| ACETYL_COA
    BCL2["BCL2"] -->|"activates"| ACETYL_COA
    GLI1["GLI1"] -->|"activates"| ACETYL_COA
    ATG["ATG"] -->|"activates"| ACETYL_COA
    BECN1["BECN1"] -->|"activates"| ACETYL_COA
    ATG7["ATG7"] -->|"activates"| ACETYL_COA
    PIK3C3["PIK3C3"] -->|"activates"| ACETYL_COA
    MITOPHAGY["MITOPHAGY"] -->|"activates"| ACETYL_COA

Outgoing (365)

Target	Relation	Type	Str
Cancer	inhibits	disease	0.95
Cancer	activates	disease	0.95
EP300	activates	protein	0.90
STAT3	activates	gene	0.90
P300	activates	protein	0.85
STAT3	activates	protein	0.85
Tumor	activates	disease	0.85
Als	activates	disease	0.85
Tumor	inhibits	disease	0.85
Obesity	activates	disease	0.85
Inflammation	activates	disease	0.85
histone acetylation	activates	phenotype	0.80
ATP	activates	gene	0.80
AUTOPHAGY	activates	gene	0.80
Autophagy	activates	pathway	0.80
MICROGLIA	activates	gene	0.80
CANCER	activates	gene	0.80
Als	regulates	disease	0.75
Als	therapeutic_target	disease	0.75
Lung Cancer	inhibits	disease	0.75
Tumor	therapeutic_target	disease	0.75
microglial_activation	modulates	mechanism	0.75
Mtor	inhibits	pathway	0.70
Angiogenesis	inhibits	pathway	0.70
GENES	activates	gene	0.70
AUTOPHAGY	regulates	gene	0.70
Lipid Metabolism	associated_with	pathway	0.70
Glycolysis	activates	pathway	0.70
Autophagy	regulates	pathway	0.70
Oxidative Phosphorylation	activates	pathway	0.70
MITOCHONDRIAL DYSFUNCTION	activates	gene	0.70
MITOCHONDRIA	activates	gene	0.70
STAT3	regulates	protein	0.70
Mitophagy	activates	pathway	0.70
Invasion	inhibits	pathway	0.70
CANCER	inhibits	gene	0.70
STAT3	activates	protein	0.70
AMPK	activates	gene	0.70
Epigenetic	regulates	pathway	0.70
Ovarian Cancer	inhibits	disease	0.65
Neuroinflammation	protects_against	disease	0.65
Ms	regulates	disease	0.65
Parkinson	protects_against	disease	0.65
Cancer	regulates	disease	0.65
Alzheimer	protects_against	disease	0.65
Pancreatic Cancer	activates	disease	0.65
Parkinson	associated_with	disease	0.65
Tumor	associated_with	disease	0.65
Ischemia	protects_against	disease	0.65
Aging	inhibits	disease	0.65

Incoming (219)

Source	Relation	Type	Str
SIRT1	activates	gene	0.70
CANCER	inhibits	gene	0.70
MITOPHAGY	activates	gene	0.70
AMPK	activates	gene	0.60
PIK3C3	activates	gene	0.60
YWHAG	activates	gene	0.60
RICTOR	activates	gene	0.60
AKT	activates	gene	0.60
ENDOG	activates	gene	0.60
MTORC1	activates	gene	0.60
BIP	activates	gene	0.60
IRE1A	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
TSC2	activates	gene	0.60
EIF2AK3	activates	gene	0.60
GSK3B	activates	gene	0.60
ERN1	activates	gene	0.60
HSPA5	activates	gene	0.60
AGING	interacts_with	gene	0.60
NEURODEGENERATIVE DISEASES	interacts_with	gene	0.60
SIRT3	regulates	gene	0.60
PGC1A	interacts_with	gene	0.60
ATP5F1	interacts_with	gene	0.60
P53	interacts_with	gene	0.60
LMNA	interacts_with	gene	0.60
HUNTINGTON'S DISEASE	interacts_with	gene	0.60
CLOCK	interacts_with	gene	0.60
SDHB	interacts_with	gene	0.60
PPARG	interacts_with	gene	0.60
PARK7	interacts_with	gene	0.60
AMPK	interacts_with	gene	0.60
BACE1	interacts_with	gene	0.60
SLC7A11	inhibits	gene	0.60
NCOA4	inhibits	gene	0.60
AMPK	regulates	gene	0.60
AKT	regulates	gene	0.60
TP53	treats	gene	0.60
CANCER	treats	gene	0.60
GFP	inhibits	gene	0.60
TFEB	inhibits	gene	0.60
PTEN	activates	gene	0.60
ARID1A	contributes_to	gene	0.60
PERK	activates	gene	0.60
DNA	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
NEURODEGENERATION	phosphorylates	gene	0.60
INFLAMMATION	phosphorylates	gene	0.60
AUTOPHAGY	activates	gene	0.60
GPX4/SLC7A11	inhibits	gene	0.60
APOE3	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ACETYL-COA in their description or question text

No additional research found