concept

MAO

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MAO: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

267Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

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💡 Concept Info

Name	MAO
Key Genes/Proteins	AADC, ABCA1, ABCG1, ACETYL-COA, ACHE, ACTB
Related Diseases	Als, ALS, Alzheimer

Wiki Pages (9)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    MAO["MAO"]
    style MAO fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    MAO -->|"catalyzes"| Neurotransmitter_Metabolism["Neurotransmitter Metabolism"]
    MAO -->|"involved_in"| Neurotoxicity["Neurotoxicity"]
    MAO -->|"regulates"| Ms["Ms"]
    MAO -.->|"inhibits"| Atherosclerosis["Atherosclerosis"]
    MAO -.->|"inhibits"| ALS["ALS"]
    MAO -.->|"inhibits"| Tumor["Tumor"]
    MAO -.->|"inhibits"| Cancer["Cancer"]
    MAO -.->|"biomarker for"| Neurodegeneration["Neurodegeneration"]
    MAO -.->|"biomarker for"| Neuroinflammation["Neuroinflammation"]
    MAO -.->|"biomarker for"| Inflammation["Inflammation"]
    GFAP([GFAP]) -->|"contributes to"| MAO
    PER([PER]) -->|"target for"| MAO
    SLC7A11([SLC7A11]) -->|"regulates"| MAO
    ACETYL_COA([ACETYL-COA]) -->|"regulates"| MAO
    GPX4([GPX4]) -->|"regulates"| MAO
    LC3([LC3]) -.->|"inhibits"| MAO
    APOE([APOE]) -.->|"inhibits"| MAO
    EIF4EBP1([EIF4EBP1]) -.->|"inhibits"| MAO
    ABCA1([ABCA1]) -.->|"inhibits"| MAO
    ULK1([ULK1]) -.->|"inhibits"| MAO

Outgoing (156)

Target	Relation	Type	Str
TAU	associated_with	gene	0.70
Als	inhibits	disease	0.65
OXIDATIVE STRESS	regulates	phenotype	0.65
Neurodegeneration	biomarker_for	disease	0.65
Inflammation	inhibits	disease	0.65
Atherosclerosis	inhibits	disease	0.65
Alzheimer	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Parkinson	inhibits	disease	0.65
Alzheimer	inhibits	disease	0.65
ALS	inhibits	disease	0.65
Anxiety	inhibits	disease	0.65
Inflammation	biomarker_for	disease	0.65
Ms	associated_with	disease	0.65
Ms	regulates	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Neuroinflammation	inhibits	disease	0.65
Neuroinflammation	biomarker_for	disease	0.65
Ferroptosis	therapeutic_target	disease	0.65
Depression	inhibits	disease	0.65
Tumor	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Ferroptosis	regulates	pathway	0.60
Autophagy	regulates	pathway	0.60
OXIDATIVE STRESS	co_discussed	pathway	0.60
FERROPTOSIS	regulates	gene	0.60
PARKINSON'S DISEASE	associated_with	gene	0.60
AND	regulates	gene	0.60
NCOA4	regulates	gene	0.60
GPX4/SLC7A11	regulates	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
Alzheimer's disease	associated_with	disease	0.60
AND	inhibits	gene	0.60
Dna Repair	inhibits	pathway	0.60
AUTOPHAGY	regulates	gene	0.60
NRF2	regulates	gene	0.60
OXIDATIVE STRESS	markers	pathway	0.60
Oxidative Stress	associated_with	pathway	0.60
Proteasome	associated_with	pathway	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
PI3K	inhibits	gene	0.60
MAP1LC3	inhibits	gene	0.60
Epigenetic	associated_with	pathway	0.60
Autophagy	inhibits	pathway	0.60
Mtor	inhibits	pathway	0.60
Ubiquitin-Proteasome	associated_with	pathway	0.60
UBIQUITIN	associated_with	gene	0.60
STING	inhibits	gene	0.60
IFN	inhibits	gene	0.60
MAX	inhibits	gene	0.60

Incoming (111)

Source	Relation	Type	Str
GFAP	associated_with	gene	0.70
ACHE	targets	gene	0.70
ROS	produces	phenotype	0.65
SQSTM1	inhibits	gene	0.60
APOA1	inhibits	gene	0.60
ATG5	inhibits	gene	0.60
ACTB	inhibits	gene	0.60
AUTOPHAGY	inhibits	gene	0.60
AMPK	inhibits	gene	0.60
ATP	inhibits	gene	0.60
MTOR	inhibits	gene	0.60
FERROPTOSIS	therapeutic_target	gene	0.60
AADC	regulates	gene	0.60
TRKA	associated_with	gene	0.60
CYP1A2	regulates	gene	0.60
MAO-B	activates	gene	0.60
TAAR1	regulates	gene	0.60
AHR	activates	gene	0.60
GENES	regulates	gene	0.60
CYP1A1	regulates	gene	0.60
ROS	regulates	gene	0.60
ANXIETY	inhibits	gene	0.60
NEUROINFLAMMATION	inhibits	gene	0.60
PARKINSON	inhibits	gene	0.60
ALZHEIMER	inhibits	gene	0.60
BDNF	inhibits	gene	0.60
DEPRESSION	inhibits	gene	0.60
TRKB	inhibits	gene	0.60
ALZHEIMER	associated_with	gene	0.60
BDNF	associated_with	gene	0.60
TRKB	associated_with	gene	0.60
NGF	associated_with	gene	0.60
ABCG1	inhibits	gene	0.60
GSTP1	regulates	gene	0.60
LRRK2	regulates	gene	0.60
EGR1	activates	gene	0.60
JNK	activates	gene	0.60
ASTROCYTE	expresses	cell_type	0.60
AD	associated_with	gene	0.60
AD	inhibits	gene	0.60
AD	targets	gene	0.60
COMT	inhibits	gene	0.60
LC3	inhibits	gene	0.60
ULK1	inhibits	gene	0.60
DRD1	associated_with	gene	0.60
PER	therapeutic_target	gene	0.60
PARKINSON	associated_with	gene	0.60
APOE	inhibits	gene	0.60
EIF4EBP1	inhibits	gene	0.60
ABCA1	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

How do gut microbiome-derived metabolites SCFAs LPS TMAO influence alpha-synucle

neurodegeneration | 2026-04-16 | 2 hypotheses Top: 0.778

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

How do gut microbiome-derived metabolites SCFAs LPS TMAO influence alpha-synucle

closed · Rounds: 4 · Score: 0.84 · 2026-04-16

Related Research

Hypotheses and analyses mentioning MAO in their description or question text

No additional research found

MAO

Understanding Entity Pages

Wiki Pages (9)

Safinamide

MAO-B Inhibitors

MAOB Protein

MAO-B Inhibitors for Parkinson's Disease — Investment Landscape Analysis

MAOA Protein

Selegiline - MAO-B Inhibitor for Parkinson's Disease

MAOB Gene

MAOA Gene

MAO-A (Monoamine Oxidase A) Protein

Pathway Diagram

Outgoing (156)

Incoming (111)

Targeting Hypotheses (0)

Mentioning Analyses (1)

How do gut microbiome-derived metabolites SCFAs LPS TMAO influence alpha-synucle

Experiments (0)

Related Papers (0)

Debates (1)

How do gut microbiome-derived metabolites SCFAs LPS TMAO influence alpha-synucle

Related Research