protein

PPAR

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PPAR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

999Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

Page for PPAR (Peroxisome Proliferator-Activated Receptor)

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🔬 Protein Info

Gene Symbol	PPAR
Full Name	PPAR (Peroxisome Proliferator-Activated Receptor)
Aliases	Peroxisome Proliferator-Activated Receptor
Protein Type	Protein
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	neurons, astrocytes, microglia, and oligodendrocytes, where they modulate critical processes including neuroinflammation, mit
Pathways	Apoptosis, Autophagy, Differentiation, Epigenetic, Lipid Metabolism
UniProt ID	Search UniProt
GeneCards	PPAR
Human Protein Atlas	PPAR
Associated Diseases	AD, Als, Alzheimer, AMI, ARDS
Known Drugs/Compounds	kaempferol, SDHHQ
Interactions	ABCA1, ABCA7, ABCB1, ACSL4, Actin, AEP
KG Connections	999 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: PPAR — AlphaFold SEARCH Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (10)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    PPAR["PPAR"] -->|"activates"| Obesity["Obesity"]
    PPAR["PPAR"] -->|"activates"| Diabetes["Diabetes"]
    PPAR["PPAR"] -->|"protects against"| Neurodegeneration["Neurodegeneration"]
    PPAR["PPAR"] -->|"activates"| Inflammation["Inflammation"]
    PPAR["PPAR"] -->|"associated with"| ALS["ALS"]
    PPAR["PPAR"] -->|"associated with"| Inflammation["Inflammation"]
    PPAR["PPAR"] -->|"activates"| Neuroinflammation["Neuroinflammation"]
    PPAR["PPAR"] -->|"activates"| ALS["ALS"]
    PPAR["PPAR"] -->|"activates"| Tumor["Tumor"]
    PPAR["PPAR"] -->|"activates"| Parkinson["Parkinson"]
    PPAR["PPAR"] -->|"activates"| Neurodegeneration["Neurodegeneration"]
    PPAR["PPAR"] -->|"activates"| TNF["TNF"]
    style PPAR fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style Obesity fill:#ef5350,stroke:#333,color:#e0e0e0
    style Diabetes fill:#ef5350,stroke:#333,color:#e0e0e0
    style Neurodegeneration fill:#ef5350,stroke:#333,color:#e0e0e0
    style Inflammation fill:#ef5350,stroke:#333,color:#e0e0e0
    style ALS fill:#ef5350,stroke:#333,color:#e0e0e0
    style Neuroinflammation fill:#ef5350,stroke:#333,color:#e0e0e0
    style Tumor fill:#ef5350,stroke:#333,color:#e0e0e0
    style Parkinson fill:#ef5350,stroke:#333,color:#e0e0e0
    style TNF fill:#4a1a6b,stroke:#333,color:#e0e0e0

Outgoing (693)

Target	Relation	Type	Str
Diabetes	activates	disease	1.00
AMPK	activates	gene	0.90
NRF2	activates	gene	0.90
Als	regulates	disease	0.85
Als	therapeutic_target	disease	0.85
Fatty Liver	activates	disease	0.85
Obesity	activates	disease	0.85
Inflammation	activates	disease	0.85
Cancer	activates	disease	0.85
Tumor	activates	disease	0.85
fatty acid metabolism	regulates	process	0.85
neural stem cells	regulates	cell_type	0.80
neural stem cells	activates	cell_type	0.80
Lipid Metabolism	activates	pathway	0.80
GENES	activates	gene	0.80
OXIDATIVE STRESS	activates	gene	0.80
CANCER	activates	gene	0.80
SIRT1	activates	gene	0.80
Oxidative Stress	activates	pathway	0.80
Tumor	associated_with	disease	0.75
Parkinson	activates	disease	0.75
Diabetes	therapeutic_target	disease	0.75
Als	activates	disease	0.75
AKT	activates	gene	0.70
lipid metabolism	participates_in	pathway	0.70
unfolded protein response	participates_in	pathway	0.70
PINK1	activates	gene	0.70
GENES	therapeutic_target	gene	0.70
LRRK2	activates	gene	0.70
INFLAMMATION	activates	gene	0.70
Wnt	activates	pathway	0.70
Cell Cycle	activates	pathway	0.70
PPAR-Γ	activates	gene	0.70
Nf-Κb	activates	pathway	0.70
NF-ΚB	activates	gene	0.70
oxidative stress response	participates_in	pathway	0.70
neural stem cells	expressed_in	cell_type	0.70
DJ-1	activates	gene	0.70
Differentiation	activates	pathway	0.70
PARKINSON	activates	gene	0.70
PI3K	activates	gene	0.70
Neuroinflammation	activates	disease	0.65
ALS	activates	disease	0.65
Fibrosis	protects_against	disease	0.65
Hypertension	activates	disease	0.65
Cardiac	activates	disease	0.65
Dementia	transports	disease	0.65
Vascular Dementia	transports	disease	0.65
Cardiomyopathy	regulates	disease	0.65
Pyroptosis	therapeutic_target	disease	0.65

Incoming (306)

Source	Relation	Type	Str
Huanglian-Hongqu herb pair	regulates	drug	0.90
SDHHQ	modulates	drug	0.85
kaempferol	activates	compound	0.80
PPAR-Γ	activates	gene	0.70
ACE	regulates	gene	0.60
PYROPTOSIS	therapeutic_target	gene	0.60
PANK1	associated_with	gene	0.60
FERROPTOSIS	inhibits	gene	0.60
DNA	interacts_with	gene	0.60
NRF2	activates	gene	0.60
EPILEPSY	interacts_with	gene	0.60
FERROPTOSIS	therapeutic_target	gene	0.60
AQP4	inhibits	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
CYTOKINES	associated_with	gene	0.60
CLDN1	activates	gene	0.60
ZCWPW1	activates	gene	0.60
HIF1A	associated_with	gene	0.60
HMGCR	therapeutic_target	gene	0.60
NLRP3	activates	entity	0.60
APOA1	activates	gene	0.60
P38	contributes_to	gene	0.60
AKT	contributes_to	gene	0.60
PYROPTOSIS	inhibits	gene	0.60
ROS	inhibits	gene	0.60
HO-1	therapeutic_target	gene	0.60
IDE	activates	gene	0.60
ANGPT1	expressed_in	gene	0.60
VEGF	expressed_in	gene	0.60
ICAM1	associated_with	gene	0.60
PPARG	associated_with	gene	0.60
NLRP3	associated_with	gene	0.60
AQP4	activates	gene	0.60
APOPTOSIS	regulates	gene	0.60
CELF1	activates	gene	0.60
ABCA7	activates	gene	0.60
CASS4	activates	gene	0.60
APOE	activates	gene	0.60
PTK2B	activates	gene	0.60
TLR4	activates	gene	0.60
CPT1A	inhibits	gene	0.60
JNK	activates	gene	0.60
NGF	activates	gene	0.60
APP	activates	gene	0.60
BDNF	activates	gene	0.60
LRP1	activates	gene	0.60
TAU	contributes_to	gene	0.60
AMPK	regulates	gene	0.60
SQSTM1	activates	gene	0.60
LXR	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PPAR in their description or question text

No additional research found

PPAR

Understanding Entity Pages

Summary

Wiki Pages (10)

PPAR (Peroxisome Proliferator-Activated Receptor)

PGC-1α (PPARGC1A)

PPAR Signaling Pathway in Neurodegeneration

PPARG — Peroxisome Proliferator-Activated Receptor Gamma

PPAR Agonists for Neurodegeneration

PGC-1α (PPARGC1A) Targeted Therapies in Neurodegeneration

PPARGC1A Gene

PPARGC1B — PPARG Coactivator 1 Beta

PPARGC1B Gene