concept

VASCULAR DEMENTIA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about VASCULAR DEMENTIA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

213Connections

1Hypotheses

0Analyses

47Outgoing

50Incoming

0Experiments

0Debates

No summary available yet.

View on Wiki →

No AI portrait yet

💡 Concept Info

Name	VASCULAR DEMENTIA
Key Genes/Proteins	APOE, APP, CREB, MMP9
Related Diseases	GLUTAMATE, GLYCOLYSIS, NEUROINFLAMMATION
Related Pathways	NLRP3 INFLAMMASOME

Pathway Diagram

graph TD
    VASCULAR_DEMENTIA["VASCULAR DEMENTIA"]
    style VASCULAR_DEMENTIA fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    VASCULAR_DEMENTIA -->|"causes"| Cerebrovascular["Cerebrovascular"]
    VASCULAR_DEMENTIA -->|"activates"| Blood_Brain_Barrier["Blood-Brain Barrier"]
    VASCULAR_DEMENTIA -.->|"inhibits"| Myelination["Myelination"]
    VASCULAR_DEMENTIA -.->|"inhibits"| Apoptosis["Apoptosis"]
    VASCULAR_DEMENTIA -.->|"inhibits"| Inflammasome["Inflammasome"]
    VASCULAR_DEMENTIA -->|"activates"| Dendritic_Spine["Dendritic Spine"]
    VASCULAR_DEMENTIA -->|"activates"| Camp_Signaling["Camp Signaling"]
    VASCULAR_DEMENTIA -.->|"inhibits"| Amyloid["Amyloid"]
    Chronic_Cerebral_Hypoperfusion["Chronic Cerebral Hypoperfusion"] -->|"causes"| VASCULAR_DEMENTIA
    FERROPTOSIS["FERROPTOSIS"] -->|"contributes to"| VASCULAR_DEMENTIA
    CHRONIC_CEREBRAL_HYPOPERFUSION["CHRONIC CEREBRAL HYPOPERFUSION"] -->|"causes"| VASCULAR_DEMENTIA
    Tong_Qiao_Huo_Xue_Decoction{"Tong-Qiao-Huo-Xue Decoction"} -->|"treats"| VASCULAR_DEMENTIA
    Cerebrovascular_Disease["Cerebrovascular Disease"] -->|"risk_factor_for"| VASCULAR_DEMENTIA
    NLRP3([NLRP3]) -->|"contributes to"| VASCULAR_DEMENTIA
    Ams_17["Ams-17"] -->|"treats"| VASCULAR_DEMENTIA
    AMS_17["AMS-17"] -->|"treats"| VASCULAR_DEMENTIA
    A3AR["A3AR"] -->|"treats"| VASCULAR_DEMENTIA

Outgoing (47)

Target	Relation	Type	Str
Tau Protein Hyperphosphorylation	associated_with	mechanism	0.90
Blood-Brain Barrier Dysfunction	associated_with	phenotype	0.85
NLRP3	associated_with	protein	0.85
ALZHEIMER'S DISEASE	associated_with	entity	0.85
Vitamin D	associated_with	chemical	0.70
blood-brain barrier	affects	brain_region	0.60
ferroptosis	involves	pathway	0.60
white matter	affects	brain_region	0.60
endothelial cells	affects	cell_type	0.60
lipid metabolism	involves	pathway	0.60
neural stem cells	affects	cell_type	0.60
Neuron	therapeutic_target	cell_type	0.55
Ferroptosis	associated_with	pathway	0.55
Cerebrovascular	causes	pathway	0.55
Blood-Brain Barrier	therapeutic_target	pathway	0.55
Endothelial	therapeutic_target	cell_type	0.55
Inflammasome	therapeutic_target	pathway	0.55
Apoptosis	therapeutic_target	pathway	0.55
Neuron	activates	cell_type	0.55
Endothelial	associated_with	cell_type	0.55
Oxidative Stress	therapeutic_target	pathway	0.55
Amyloid	associated_with	pathway	0.55
Blood-Brain Barrier	activates	pathway	0.55
Myelination	inhibits	pathway	0.55
Apoptosis	inhibits	pathway	0.55
Inflammasome	inhibits	pathway	0.55
Blood-Brain Barrier	inhibits	pathway	0.55
Apoptosis	activates	pathway	0.55
Dendritic Spine	activates	pathway	0.55
Camp Signaling	activates	pathway	0.55
Amyloid	inhibits	pathway	0.55
Calcium Signaling	expressed_in	pathway	0.55
Blood-Brain Barrier	causes	pathway	0.55
Cerebrovascular	associated_with	pathway	0.55
Oxidative Stress	interacts_with	pathway	0.55
Amyloid	interacts_with	pathway	0.55
Blood-Brain Barrier	interacts_with	pathway	0.55
Sod1	interacts_with	pathway	0.55
Oligodendrocyte	interacts_with	cell_type	0.55
Opc	interacts_with	cell_type	0.55
APP	associated_with	gene	0.50
APOE	associated_with	gene	0.50
Cortex	associated_with	brain_region	0.50
White Matter	associated_with	brain_region	0.50
Hippocampus	associated_with	brain_region	0.50
CREB	associated_with	gene	0.45
PREFRONTAL CORTEX	associated_with	brain_region	0.45

Incoming (166)

Source	Relation	Type	Str
Chronic Cerebral Hypoperfusion	causes	process	0.95
FERROPTOSIS	contributes_to	entity	0.95
Tong-Qiao-Huo-Xue Decoction	treats	drug	0.95
CHRONIC CEREBRAL HYPOPERFUSION	causes	entity	0.95
cardiovascular disease	causes	disease	0.90
Nerve cell damage	contributes_to	phenotype	0.90
NLRP3	contributes_to	protein	0.90
Chronic Cerebral Hypoperfusion	contributes_to	disease	0.90
Cerebrovascular Disease	risk_factor_for	disease	0.90
Ams-17	treats	compound	0.85
Oligodendrocytes	involved_in	cell_type	0.85
PAL	treats	compound	0.85
BDNF	biomarker_for	protein	0.80
TNF-α	biomarker_for	protein	0.80
A3AR	treats	receptor	0.80
Ferroptosis	accelerates	process	0.80
MMP9	contributes_to	protein	0.75
FERROPTOSIS	effect_on	process	0.70
NEUROINFLAMMATION	inhibits	gene	0.65
AMYOTROPHIC LATERAL SCLEROSIS	contributes_to	gene	0.65
TNF	inhibits	gene	0.65
PARKINSON	contributes_to	gene	0.65
IL-4	inhibits	gene	0.65
NEURODEGENERATIVE DISEASES	contributes_to	gene	0.65
APOPTOSIS	inhibits	gene	0.65
PARKINSON'S DISEASE	contributes_to	gene	0.65
ALS	contributes_to	gene	0.65
TNF-Α	inhibits	gene	0.65
ASC	contributes_to	gene	0.65
EXOSOMES	inhibits	gene	0.65
ALZHEIMER	inhibits	gene	0.65
ALZHEIMER'S DISEASE	inhibits	gene	0.65
AMYLOID	inhibits	gene	0.65
TAU	inhibits	gene	0.65
DEMENTIA	protects_against	gene	0.65
APOE	interacts_with	gene	0.65
INFLAMMATION	interacts_with	gene	0.65
SOD1	interacts_with	gene	0.65
TNF	interacts_with	gene	0.65
CLDN5	interacts_with	gene	0.65
NATURAL COMPOUNDS	interacts_with	gene	0.65
OXIDATIVE STRESS	interacts_with	gene	0.65
MMP9	interacts_with	gene	0.65
IL-17	interacts_with	gene	0.65
AND	protects_against	gene	0.65
APLP1	interacts_with	gene	0.65
AMYLOID	interacts_with	gene	0.65
GLYCOLYSIS	causes	phenotype	0.65
AND	causes	gene	0.65
SERPINE2	interacts_with	gene	0.65

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
C1Q-Glia Cross-Talk in Vascular Dementia Pathogenesis	0.470	neuroinflammation	What are the specific molecular mechanis

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning VASCULAR DEMENTIA in their description or question text

No additional research found