gene

PANK1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PANK1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

23Connections

0Hypotheses

0Analyses

17Outgoing

6Incoming

0Experiments

0Debates

Summary

PANK1 gene page

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🧬 Gene Info

Gene Symbol	PANK1
Full Name	Pantothenate Kinase 1
Aliases	PANK1 Protein
Chromosome	10q23.31
Protein Type	Enzyme
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	various brain regions:
Molecular Weight	63 kDa
Amino Acids	571 aa
Pathways	Lipid Metabolism
Ensembl ID	ENSG00000167191
GeneCards	PANK1
Human Protein Atlas	PANK1
N-terminal domain	Regulatory region with feedback inhibition sites
Catalytic core	ATP-binding pocket and pantothenate-binding site
Associated Diseases	neurodegeneration
Interactions	Actin, PANX1, PPAR, Proteins, RNA, TGM2
KG Connections	23 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

PANK1 — Pantothenate Kinase 1

gene · 1267 words

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PANK1 Protein

protein · 1270 words

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Pathway Diagram

flowchart TD
    N0["PANK1"]
    N1["AKT"]
    N1 -->|"regulates"| N0
    N2["CoA biosynthesis"]
    N0 -->|"regulates"| N2
    N3["PANX1"]
    N0 -->|"activates"| N3
    N4["TGM2"]
    N0 -->|"activates"| N4
    N5["PPAR"]
    N0 -->|"activates"| N5
    N6["Lipid Metabolism"]
    N0 -->|"regulates"| N6
    N7["Actin"]
    N0 -->|"activates"| N7
    N5 -->|"activates"| N0
    N8["RNA"]
    N8 -->|"activates"| N0
    N9["AND"]
    N9 -->|"activates"| N0
    N3 -->|"activates"| N0
    N10["LIPID METABOLISM"]
    N0 -->|"activates"| N10
    N11["Nephropathy"]
    N0 -->|"activates"| N11
    N0 -->|"regulates"| N5

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N1 gene
    class N3 gene
    class N4 gene
    class N5 gene
    class N6 pathway
    class N7 protein
    class N8 gene
    class N9 gene
    class N10 pathway
    class N11 disease

Outgoing (17)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:PANK1	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
CoA biosynthesis	regulates	process	0.70
lipid metabolism	participates_in	pathway	0.60
PANX1	activates	gene	0.60
TGM2	activates	gene	0.60
PPAR	activates	gene	0.60
TGM2	associated_with	gene	0.60
Actin	activates	protein	0.60
PPAR	associated_with	gene	0.60
Lipid Metabolism	regulates	pathway	0.60
PPAR	regulates	protein	0.50
LIPID METABOLISM	activates	pathway	0.50
Nephropathy	activates	disease	0.50
LIPID METABOLISM	regulates	pathway	0.50
Proteins	regulates	protein	0.50
Proteins	activates	protein	0.50

Incoming (6)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:PANK1	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
PANX1	activates	gene	0.60
PPAR	activates	gene	0.60
RNA	activates	gene	0.60
TGM2	activates	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PANK1 in their description or question text

No additional research found