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protein 2,474 words KG: PGC1ALPHA
Contents

PGC-1α (PPARGC1A)

🔬 Protein Info
Gene SymbolPGC
Full Name1α (PPARGC1A)
AliasesPGC1ALPHA
FunctionPgc 1Α Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
GeneCardsPGC
Human Protein AtlasPGC
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (11)

Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.72Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70Digital Twin-Guided Metabolic Reprogramming
Score: 0.55HDAC3-Selective Inhibition for Clock Reset
Score: 0.71Arginine Methylation Enhancement Therapy
Score: 0.65TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
Score: 0.65Synthetic Biology Rewiring via Orthogonal Receptors
Score: 0.65TFEB-PGC1α Mitochondrial-Lysosomal Decoupling
Score: 0.62Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62

Related Analyses (7)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archivedDigital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archivedMitochondrial transfer between astrocytes and neurons
neurodegeneration · archivedEpigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archivedCircuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (16)

GWAS meta-analysis of major depressive disorder across three
exploratory · proposed · Score: 0.95PGC-1α knockout effects on PV+ interneuron maturation
validation · proposed · Score: 0.90Differential GWAS of schizophrenia vs PTSD
exploratory · proposed · Score: 0.90PGC-1α knockout analysis of PV+ interneuron maturation
validation · proposed · Score: 0.85TUG C-terminal product nuclear localization and PPARγ bindin
exploratory · proposed · Score: 0.85

See Also (15)

PARK7 — Parkinsonism Associated Deglycase (DJ-1)
gene · KG edge: regulatesNeurofilament Medium Chain (NfM) - Biomarker
biomarker · KG edge: regulatesHNRNPA1 Gene
gene · KG edge: regulatesNURR1 Gene
gene · KG edge: regulatesAPP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: regulates

Knowledge Graph (12 edges)

LMX1B regulates PGC1ALPHA
PINK1 regulates PGC1ALPHA
SNCA regulates PGC1ALPHA
SFPQ regulates PGC1ALPHA
NFM regulates PGC1ALPHA
HNRNPA1 regulates PGC1ALPHA
PGC1ALPHA regulates NURR1
PGC1ALPHA regulates PARK7
PARK7 regulates PGC1ALPHA
PGC1ALPHA regulates LMX1B

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