gene

EPILEPSY

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about EPILEPSY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2845Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

EPILEPSY is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, therapeutic target. Associated with ALS, ALZHEIMER'S DISEASE, AMYOTROPHIC LATERAL SCLEROSIS. Connected to 508 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	EPILEPSY
Aliases	Seizure disorder, Epileptic syndrome
Input	Excitatory inputs from thalamocortical relay neurons (collaterals) and cortical pyramidal neurons (layer 6)
Output	Inhibitory projections to thalamic relay nuclei, modulating sensory transmission
Intrinsic circuitry	Gap junctions between TRN neurons enable synchronized activity
GABA_A receptors	Fast inhibitory transmission
GABA_B receptors	Metabotropic inhibition
Associated Diseases	Aging, Als, Alzheimer, Alzheimer Disease, ALZHEIMER_DISEASE
Known Drugs/Compounds	BRIVARACETAM, DASATINIB, Nec-1s, QUERCETIN, TIAGABINE
Interactions	Actin, Akt, AKT, AKT3, ALZHEIMER, ALZHEIMER'S DISEASE
KG Connections	1651 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Thalamic Reticular Nucleus in Epilepsy

cell · 803 words

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Pathway Diagram

flowchart TD
    EPILEPSY(["EPILEPSY"])
    Epilepsy["Epilepsy"]
    Als["Als"]
    Inflammation["Inflammation"]
    Neurodegeneration["Neurodegeneration"]
    ALZHEIMER_S_DISEASE(["ALZHEIMER'S DISEASE"])
    ALZHEIMER(["ALZHEIMER"])
    Mtor["Mtor"]
    MTOR(["MTOR"])
    Alzheimer["Alzheimer"]
    Parkinson["Parkinson"]
    Neuroinflammation["Neuroinflammation"]

    EPILEPSY -->|"associated with"| Epilepsy
    EPILEPSY -->|"therapeutic target"| Als
    EPILEPSY -->|"therapeutic target"| Epilepsy
    EPILEPSY -->|"activates"| Inflammation
    EPILEPSY -->|"activates"| Als
    EPILEPSY -->|"activates"| Neurodegeneration
    EPILEPSY -->|"associated with"| ALZHEIMER_S_DISEASE
    EPILEPSY -->|"associated with"| ALZHEIMER
    EPILEPSY -->|"therapeutic target"| Mtor
    EPILEPSY -->|"therapeutic target"| MTOR
    ALZHEIMER_S_DISEASE -->|"associated with"| EPILEPSY
    EPILEPSY -->|"associated with"| Alzheimer
    EPILEPSY -->|"causes"| Epilepsy
    EPILEPSY -->|"associated with"| Parkinson
    EPILEPSY -->|"activates"| Neuroinflammation

    style EPILEPSY fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (1405)

Target	Relation	Type	Str
Als	activates	disease	1.00
Als	activates	disease	1.00
Inflammation	activates	disease	1.00
Inflammation	activates	disease	1.00
Als	therapeutic_target	disease	1.00
Epilepsy	associated_with	disease	1.00
Epilepsy	therapeutic_target	disease	1.00
Neurodegeneration	activates	disease	1.00
ALZHEIMER'S DISEASE	associated_with	gene	1.00
ALZHEIMER	associated_with	gene	1.00
MTOR	therapeutic_target	gene	1.00
Mtor	therapeutic_target	pathway	1.00
Mtor	therapeutic_target	pathway	1.00
Alzheimer	associated_with	disease	0.95
Neurodegeneration	activates	disease	0.95
Epilepsy	causes	disease	0.95
Alzheimer	therapeutic_target	disease	0.95
Sudden Unexpected Death in Epilepsy	contributes_to	disease	0.95
Neuroinflammation	activates	disease	0.95
Alzheimer	associated_with	disease	0.95
Parkinson	associated_with	disease	0.95
neurons	affects	cell_type	0.90
HIPPOCAMPAL_SCLEROSIS	associated_with	disease	0.90
oxidative stress response	involves	pathway	0.90
astrocytes	affects	cell_type	0.90
temporal lobe	affects	brain_region	0.90
neural stem cells	affects	cell_type	0.90
TEMPORAL_LOBE	part_of	cell_type	0.90
hippocampus	affects	brain_region	0.90
microglia	affects	cell_type	0.90
cortex	affects	brain_region	0.90
PARKINSON	associated_with	gene	0.90
Oxidative Stress	therapeutic_target	pathway	0.90
ASTROCYTE	activates	gene	0.90
ALZHEIMER	therapeutic_target	gene	0.90
Als	therapeutic_target	disease	0.85
Als	associated_with	disease	0.85
Parkinson	associated_with	disease	0.85
Als	associated_with	disease	0.85
Neurodegeneration	therapeutic_target	disease	0.85
Epilepsy	contributes_to	disease	0.85
Epilepsy	regulates	disease	0.85
Parkinson	therapeutic_target	disease	0.85
Inflammation	therapeutic_target	disease	0.85
Neuroinflammation	therapeutic_target	disease	0.85
Neuroinflammation	activates	disease	0.85
Alzheimer	therapeutic_target	disease	0.85
pyroptosis	involves	pathway	0.80
glutamate receptor	involves	receptor	0.80
PI3K-AKT-mTOR signaling	involves	pathway	0.80

Incoming (1440)

Source	Relation	Type	Str
ALZHEIMER'S DISEASE	associated_with	gene	1.00
EPILEPSY	therapeutic_target	gene	1.00
NEUROINFLAMMATION	activates	gene	1.00
ALZHEIMER'S DISEASE	associated_with	gene	1.00
NEURODEGENERATION	activates	gene	1.00
PARKINSON'S DISEASE	associated_with	gene	1.00
MTOR	therapeutic_target	gene	1.00
EPILEPSY	associated_with	gene	1.00
NEURODEGENERATION	associated_with	gene	0.98
MICROGLIA	implicated_in	cell_type	0.95
NEURODEGENERATIVE DISEASES	therapeutic_target	gene	0.95
Tuberous Sclerosis Complex	causes	disease	0.95
OXIDATIVE STRESS	therapeutic_target	gene	0.95
NEURODEGENERATION	therapeutic_target	gene	0.95
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.95
ALZHEIMER	therapeutic_target	gene	0.95
ALZHEIMER	associated_with	gene	0.95
GABRA1	causes	gene	0.95
EPILEPSY	causes	gene	0.95
CORTEX	interacts_with	brain_region	0.95
ASTROCYTE	activates	gene	0.95
ASTROCYTES	activates	gene	0.95
GABRG2	causes	gene	0.95
Antiseizure Medications	treats	drug	0.95
PARKINSON	associated_with	gene	0.95
APOPTOSIS	activates	gene	0.95
Neuroinflammation	involved_in	process	0.90
MTOR	involved_in	gene	0.90
Glioblastoma Multiforme	causes	disease	0.90
AUTOPHAGY GENE MUTATIONS	causes	gene	0.90
RLN1	associated_with	protein	0.90
HMGB1	biomarker_for	protein	0.90
M305L	risk_factor_for	biomarker	0.90
D401H	risk_factor_for	biomarker	0.90
Neuroinflammatory Pathways	involved_in	pathway	0.90
Glioblastoma Multiforme	associated_with	disease	0.90
Inhibitory Synapse Elimination	contributes_to	process	0.90
Autophagy	associated_with	pathway	0.90
Ih Current	associated_with	mechanism	0.90
everolimus	treats	drug	0.90
HCN1 MUTATIONS	causes	gene	0.90
ASTROCYTES	associated_with	cell_type	0.90
PARKINSON'S DISEASE	associated_with	gene	0.85
RELN	implicated_in	entity	0.85
Physical Exercise	protects_against	process	0.85
PROPOFOL	treats	entity	0.85
MICROGLIA	activates	gene	0.85
RLN	associated_with	protein	0.85
PARKINSON	therapeutic_target	gene	0.85
AMPK	therapeutic_target	gene	0.85

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity