gene

HMGCR

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HMGCR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

836Connections

0Hypotheses

3Analyses

50Outgoing

50Incoming

0Experiments

3Debates

Summary

HMGCR is a gene implicated in neurodegeneration research. Key relationships include: associated with, interacts with, inhibits. Associated with AD, ALS, AMI. Connected to 244 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	HMGCR
Full Name	3-Hydroxy-3-Methylglutaryl-CoA Reductase
Chromosome	5
Function	HMGCR plays a critical role in cholesterol metabolism, which is intimately connected to Alzheimer's disease pathogenesis through multiple mechanisms:
Pathways	Amyloid, Autophagy, Cholesterol, Cholesterol Metabolism, Lipid Metabolism
UniProt ID	[P04035](https://www.uniprot.org/uniprotkb/P04035/entry)
Ensembl ID	ENSG00000013113
GeneCards	HMGCR
Human Protein Atlas	HMGCR
Associated Diseases	AD, Als, Alzheimer, Alzheimer disease, Alzheimer's disease
Known Drugs/Compounds	25-Hydroxycholesterol, SIMVASTATIN, statins
Interactions	A2M, ABCA1, ACSL4, AGING, Akt, AKT
KG Connections	836 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

HMGCR — 3-Hydroxy-3-Methylglutaryl-CoA Reductase

gene · 612 words

→

HMGCR Protein — HMG-CoA Reductase

protein · 559 words

→

Pathway Diagram

flowchart TD
    HMGCR["HMGCR
HMG-CoA Reductase
Rate-limiting enzyme"]
    
    Cholesterol["Cholesterol
Biosynthesis
Pathway"]
    Statins["Statin Therapy
HMGCR Inhibition"]
    
    APP["APP
Amyloid Precursor
Protein"]
    PSEN1["PSEN1
Presenilin-1
gamma-secretase component"]
    MAPT["MAPT
Tau Protein
Microtubule binding"]
    
    Inflammation["Neuroinflammation
IL1B-mediated
responses"]
    IL1B["IL1B
Interleukin-1beta
Pro-inflammatory"]
    
    Apoptosis["Apoptosis
Pathway
Cell death"]
    PARP1["PARP1
DNA repair
enzyme"]
    DAPK1["DAPK1
Death-associated
protein kinase"]
    
    Alzheimer["Alzheimer's
Disease"]
    ALS["ALS
Motor neuron
degeneration"]
    Dementia["Dementia
Cognitive decline"]
    Depression["Depression
Mood disorder"]
    
    HMGCR -->|"regulates"| Cholesterol
    HMGCR -->|"interacts_with"| APP
    HMGCR -->|"interacts_with"| PSEN1
    HMGCR -->|"interacts_with"| MAPT
    HMGCR -->|"inhibits"| Inflammation
    HMGCR -->|"interacts_with"| IL1B
    HMGCR -->|"modulates"| Apoptosis
    HMGCR -->|"interacts_with"| PARP1
    HMGCR -->|"interacts_with"| DAPK1
    
    Statins -->|"inhibits"| HMGCR
    
    APP -->|"contributes_to"| Alzheimer
    PSEN1 -->|"contributes_to"| Alzheimer
    MAPT -->|"contributes_to"| Alzheimer
    
    HMGCR -->|"associated_with"| Alzheimer
    HMGCR -->|"associated_with"| ALS
    HMGCR -->|"therapeutic_target"| Dementia
    HMGCR -->|"associated_with"| Depression
    
    Apoptosis -->|"leads_to"| ALS
    Inflammation -->|"contributes_to"| Alzheimer
    
    style HMGCR fill:#006494
    style Statins fill:#1b5e20
    style Cholesterol fill:#4a1a6b
    style Inflammation fill:#ef5350
    style Apoptosis fill:#ef5350
    style Alzheimer fill:#5d4400
    style ALS fill:#5d4400
    style Dementia fill:#5d4400
    style Depression fill:#5d4400
    style APP fill:#4a1a6b
    style PSEN1 fill:#4a1a6b
    style MAPT fill:#4a1a6b

Outgoing (496)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:HMGCR	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
cholesterol synthesis	upstream_of	process	0.90
lipid metabolism	participates_in	pathway	0.80
neurons	inhibits	cell_type	0.80
multiple sclerosis	implicated_in	disease	0.80
cerebral ischemic stroke	implicated_in	disease	0.80
excitotoxicity	inhibits	biological_process	0.80
apolipoprotein E	regulates	protein	0.80
pro-inflammatory/anti-inflammatory cytokines	balances	biological_process	0.80
matrix metalloproteinases	modulates	protein	0.80
reactive oxygen and nitrogen species	inhibits	biological_process	0.80
Amyloid-β	regulates	protein	0.80
cerebral blood perfusion	increases	biological_process	0.80
endothelial nitric oxide synthase	stimulates	protein	0.80
unfolded protein response	participates_in	pathway	0.80
oxidative stress response	participates_in	pathway	0.70
membrane lipid composition	modulates	mechanism	0.70
neurons	activates	cell_type	0.70
neural stem cells	regulates	cell_type	0.70
AKT	therapeutic_target	gene	0.70
Cholesterol	activates	pathway	0.70
Als	activates	disease	0.65
Ms	associated_with	disease	0.65
Neurodegeneration	regulates	disease	0.65
Parkinson	associated_with	disease	0.65
Cancer	activates	disease	0.65
Alzheimer	regulates	disease	0.65
Als	expressed_in	disease	0.65
Ferroptosis	activates	disease	0.65
Aging	regulates	disease	0.65
Alzheimer	inhibits	disease	0.65
Fibrosis	activates	disease	0.65
Multiple Sclerosis	activates	disease	0.65
Aging	activates	disease	0.65
Senescence	activates	disease	0.65
Pyroptosis	activates	disease	0.65
Ms	activates	disease	0.65
Tumor	activates	disease	0.65
SIMVASTATIN	inhibits	drug	0.65
Inflammation	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Tumor	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Cancer	expressed_in	disease	0.65
Als	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Cardiovascular	inhibits	disease	0.65
Cirrhosis	activates	disease	0.65

Incoming (340)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:HMGCR	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
TDP-43	binds	protein	1.00
h-a87702b6	targets_gene	hypothesis	0.90
statins	inhibits	compound	0.90
TNF	upregulates	protein	0.90
25-Hydroxycholesterol	modulates	compound	0.85
BECN1-HSPA5 complex	promotes	protein	0.83
statins	activates	compound	0.80
IL6	interacts_with	gene	0.70
TNF	interacts_with	gene	0.70
IL1B	interacts_with	gene	0.70
PI3K	therapeutic_target	gene	0.70
CHOLESTEROL	destabilizes	phenotype	0.65
NF-KB SIGNALING	activates	pathway	0.65
BRCA2	modifies	gene	0.65
NF-KB SIGNALING	regulates	pathway	0.65
LIPID PEROXIDATION	treats	phenotype	0.65
APOE4	activates	gene	0.65
OPRM1	associated_with	gene	0.60
SLC6A2	associated_with	gene	0.60
BECN1	activates	gene	0.60
FASN	therapeutic_target	gene	0.60
FASN	expressed_in	entity	0.60
NEURODEGENERATIVE DISORDERS	activates	gene	0.60
SREBP-2	regulates	protein	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
AND	activates	gene	0.60
AMYLOID	regulates	gene	0.60
ALZHEIMER	inhibits	gene	0.60
HSPG2	interacts_with	gene	0.60
DYNEIN	interacts_with	gene	0.60
SLC30A8	associated_with	gene	0.60
SLC6A3	associated_with	gene	0.60
SCD1	activates	gene	0.60
NRP1	activates	gene	0.60
APP	inhibits	gene	0.60
CXCL8	therapeutic_target	gene	0.60
MMP3	therapeutic_target	gene	0.60
ICAM1	therapeutic_target	gene	0.60
INSC	activates	gene	0.60
AUTOPHAGY	therapeutic_target	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
CCL20	therapeutic_target	gene	0.60
PPAR	inhibits	gene	0.60
TNF	activates	gene	0.60
ABCA1	causes	gene	0.60
APOE	causes	gene	0.60
CYP46A1	causes	gene	0.60
BDNF	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (3)

Scientific analyses that reference this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (3)

Multi-agent debates referencing this entity