concept

CPT1A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CPT1A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

187Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

1Experiments

0Debates

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💡 Concept Info

Name	CPT1A
Key Genes/Proteins	ACACA, ACSL4, ACTB, Actin, ADRB1, AGING
Related Diseases	Aging, Als, ALS
Related Pathways	Apoptosis

Pathway Diagram

graph TD
    CPT1A["CPT1A"]
    style CPT1A fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    CPT1A -->|"regulates"| fatty_acid_oxidation["fatty acid oxidation"]
    CPT1A -.->|"inhibits"| ferroptosis["ferroptosis"]
    CPT1A -->|"promotes"| immunotherapy_resistance(immunotherapy resistance)
    CPT1A -->|"regulates"| Ischemia["Ischemia"]
    CPT1A -->|"activates"| Metabolic_Syndrome["Metabolic Syndrome"]
    CPT1A -->|"activates"| Tumor["Tumor"]
    CPT1A -->|"activates"| Cancer["Cancer"]
    CPT1A -.->|"inhibits"| Fibrosis["Fibrosis"]
    CPT1A -.->|"inhibits"| Inflammation["Inflammation"]
    CPT1A -.->|"inhibits"| Hepatitis["Hepatitis"]
    PLIN2([PLIN2]) -->|"binds"| CPT1A
    L_carnitine{"L-carnitine"} -->|"interacts"| CPT1A
    LAMP1([LAMP1]) -->|"regulates"| CPT1A
    RAB7A([RAB7A]) -->|"regulates"| CPT1A
    PPARA([PPARA]) -->|"regulates"| CPT1A
    MITOCHONDRIA([MITOCHONDRIA]) -->|"activates"| CPT1A
    RAS([RAS]) -->|"regulates"| CPT1A
    EIF4EBP1([EIF4EBP1]) -->|"regulates"| CPT1A
    MAP1LC3B([MAP1LC3B]) -->|"regulates"| CPT1A

Outgoing (129)

Target	Relation	Type	Str
fatty acid oxidation	regulates	pathway	0.95
ferroptosis	inhibits	process	0.90
lipid droplet-mitochondria tethering	mediates	process	0.90
immunotherapy resistance	promotes	phenotype	0.85
Lipid Oxidation	involved_in	process	0.80
Als	inhibits	disease	0.65
Cancer	activates	disease	0.65
Tumor	activates	disease	0.65
Aging	therapeutic_target	disease	0.65
ALS	inhibits	disease	0.65
Carcinoma	inhibits	disease	0.65
Ischemia	regulates	disease	0.65
Metabolic Syndrome	activates	disease	0.65
Fibrosis	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
Hepatitis	inhibits	disease	0.65
PYROPTOSIS	inhibits	gene	0.60
BAX	inhibits	gene	0.60
HMGCR	inhibits	gene	0.60
INFLAMMATION	inhibits	gene	0.60
TNF	inhibits	gene	0.60
MLKL	inhibits	gene	0.60
APOPTOSIS	inhibits	gene	0.60
TNF-Α	inhibits	gene	0.60
GENES	inhibits	gene	0.60
Necroptosis	inhibits	pathway	0.60
Apoptosis	inhibits	pathway	0.60
Ferroptosis	inhibits	pathway	0.60
Pyroptosis	inhibits	pathway	0.60
APOPTOSIS	activates	gene	0.60
JUN	activates	gene	0.60
PLIN2	activates	gene	0.60
Raf	regulates	protein	0.60
Fus	regulates	protein	0.60
CTSD	activates	gene	0.60
EGFR	activates	gene	0.60
EIF4EBP1	activates	gene	0.60
LAMP1	activates	gene	0.60
LRP2	activates	gene	0.60
MAP1LC3B	activates	gene	0.60
MTOR	activates	gene	0.60
MTORC1	activates	gene	0.60
NADH	activates	gene	0.60
PIK3C3	activates	gene	0.60
PPARA	activates	gene	0.60
PPARG	activates	gene	0.60
PPARGC1A	activates	gene	0.60
RAB7A	activates	gene	0.60
RAS	activates	gene	0.60
RPS6KB1	activates	gene	0.60

Incoming (58)

Source	Relation	Type	Str
PLIN2	binds_to	entity	0.90
h-edfd6c89	targets_gene	hypothesis	0.90
L-carnitine	interacts_with	drug	0.85
CDH1	therapeutic_target	gene	0.60
PER	therapeutic_target	gene	0.60
CACNB3	associated_with	gene	0.60
ADRB1	associated_with	gene	0.60
AGING	therapeutic_target	gene	0.60
CPT2	associated_with	gene	0.60
ACTB	activates	gene	0.60
ATG	activates	gene	0.60
ATP	activates	gene	0.60
CAT	activates	gene	0.60
rapamycin	targets	drug	0.60
PLIN2	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
JUN	activates	gene	0.60
SCD1	inhibits	gene	0.60
ACSL4	inhibits	gene	0.60
ROS	inhibits	gene	0.60
ALOX15	inhibits	gene	0.60
FASN	inhibits	gene	0.60
PPAR	inhibits	gene	0.60
HMGCR	inhibits	gene	0.60
PYROPTOSIS	inhibits	gene	0.60
APOPTOSIS	inhibits	gene	0.60
ACACA	activates	gene	0.60
ALDH2	activates	gene	0.60
CAV1	inhibits	gene	0.60
PPARG	regulates	gene	0.60
PPARGC1A	regulates	gene	0.60
SREBF1	regulates	gene	0.60
CTSD	regulates	gene	0.60
NADH	regulates	gene	0.60
ACTB	regulates	gene	0.60
MTOR	regulates	gene	0.60
MTORC1	regulates	gene	0.60
PIK3C3	regulates	gene	0.60
CAT	regulates	gene	0.60
AUTOPHAGY	regulates	gene	0.60
RPS6KB1	regulates	gene	0.60
RUBCN	regulates	gene	0.60
SQSTM1	regulates	gene	0.60
EGFR	regulates	gene	0.60
RPS6	regulates	gene	0.60
ATG	regulates	gene	0.60
LRP2	regulates	gene	0.60
ATP	regulates	gene	0.60
RAB7A	regulates	gene	0.60
PPARA	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
High fat diet aging study in CPT1A knockout mice	validation	kidney aging and metabolic dys	0.850	0.00	conditional CPT1A knockout mic	proposed	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CPT1A in their description or question text

No additional research found