concept

ANGPT1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ANGPT1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

364Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

ANGPT1 is a concept in neurodegeneration research. Key relationships include: activates, co discussed, associated with. Associated with ALS, Als, Arthritis. Connected to 85 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	ANGPT1
Key Genes/Proteins	Actin, Adiponectin, AHR, AKT, ALZHEIMER, ALZHEIMER'S DISEASE
Related Diseases	Als, ALS, Alzheimer, Alzheimer's disease
Related Pathways	Adaptive Immunity, Akt, Amyloid

🔮 Predicted Structure: ANGPT1 — AlphaFold E5RFF4 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Pathway Diagram

graph TD
    ANGPT1["ANGPT1"]
    ANGPT1 -->|"expressed in"| Pericyte_Derived_Extracellular["Pericyte-Derived Extracellular Vesicles"]
    ANGPT1 -->|"regulates"| Vascular_Permeability["Vascular Permeability"]
    ANGPT1 -->|"activates"| PI3K_AKT_Pathway["PI3K/AKT Pathway"]
    ANGPT1 -->|"regulates"| Intestinal_Barrier_Function["Intestinal Barrier Function"]
    ANGPT1 -->|"downregulates"| Inflammatory_Cytokines["Inflammatory Cytokines"]
    ANGPT1 -->|"activates"| Als["Als"]
    ANGPT1 -->|"activates"| Cancer["Cancer"]
    ANGPT1 -->|"activates"| Ms["Ms"]
    ANGPT1 -->|"activates"| Tumor["Tumor"]
    ANGPT1 -->|"activates"| Arthritis["Arthritis"]
    h_35f04e1b["h-35f04e1b"] -->|"targets"| ANGPT1
    BMP2["BMP2"] -->|"activates"| ANGPT1
    VEGF["VEGF"] -->|"activates"| ANGPT1
    FGF2["FGF2"] -->|"activates"| ANGPT1
    CD8["CD8"] -->|"activates"| ANGPT1
    VEGFB["VEGFB"] -->|"activates"| ANGPT1
    RUNX2["RUNX2"] -->|"activates"| ANGPT1
    PDGFRB["PDGFRB"] -->|"activates"| ANGPT1
    GENES["GENES"] -->|"activates"| ANGPT1
    PI3K["PI3K"] -->|"activates"| ANGPT1

Outgoing (267)

Target	Relation	Type	Str
vascular barrier function	promotes	phenotype	0.95
Pericyte-Derived Extracellular Vesicles	expressed_in	cell_type	0.95
Vascular Barrier Function	associated_with	process	0.95
Pericyte-Derived Extracellular Vesicles	component_of	compound	0.92
Angiogenesis-Related Pathway	involved_in	pathway	0.90
Vascular Permeability	regulates	phenotype	0.90
Vascular Barrier Function	activates	phenotype	0.90
Pericyte Recruitment	mediates	process	0.85
vascular endothelial cell proliferation	promotes	process	0.85
Angiogenesis	associated_with	process	0.85
PI3K/AKT Pathway	activates	pathway	0.85
Intestinal Barrier Function	protects_against	phenotype	0.85
Pericyte Recruitment	regulates	process	0.85
Sepsis	treats	disease	0.80
Pericyte Recruitment	promotes	process	0.80
Intestinal Barrier Function	associated_with	phenotype	0.80
Intestinal Barrier Function	regulates	phenotype	0.80
Inflammatory Cytokines	downregulates	biomarker	0.75
Sepsis	associated_with	disease	0.70
ALS	activates	disease	0.65
Als	expressed_in	disease	0.65
Tumor	associated_with	disease	0.65
Ms	activates	disease	0.65
Sepsis	interacts_with	disease	0.65
Als	activates	disease	0.65
Tumor	activates	disease	0.65
Dementia	expressed_in	disease	0.65
Cancer	therapeutic_target	disease	0.65
Cancer	activates	disease	0.65
Alzheimer	causes	disease	0.65
Als	therapeutic_target	disease	0.65
Cardiovascular	activates	disease	0.65
Cancer	expressed_in	disease	0.65
Stroke	associated_with	disease	0.65
Als	associated_with	disease	0.65
Alzheimer	expressed_in	disease	0.65
Ischemia	associated_with	disease	0.65
Arthritis	activates	disease	0.65
Obesity	activates	disease	0.65
Diabetes	inhibits	disease	0.65
Ischemia	activates	disease	0.65
ALS	expressed_in	disease	0.65
ALS	causes	disease	0.65
Als	causes	disease	0.65
Carcinoma	inhibits	disease	0.65
ALS	associated_with	disease	0.65
Inflammation	activates	disease	0.65
ASTROCYTES	associated_with	gene	0.60
Mapk	associated_with	pathway	0.60
ALZHEIMER	causes	gene	0.60

Incoming (97)

Source	Relation	Type	Str
Pericyte-derived Extracellular Vesicles	associated_with	cell_type	0.90
Pericyte-derived Extracellular Vesicles	component_of	structure	0.90
Pericyte-Derived Extracellular Vesicles	transports	cell_type	0.90
h-35f04e1b	targets	hypothesis	0.90
Pericyte-Derived Extracellular Vesicles	associated_with	cell_type	0.85
STING	upregulates	protein	0.85
extracellular vesicles	associated_with	gene	0.70
TAU	causes	gene	0.60
HDAC2	activates	gene	0.60
GBM	associated_with	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
YAP	activates	gene	0.60
HIF-1Α	activates	gene	0.60
GENES	associated_with	gene	0.60
WNT	activates	gene	0.60
ALZHEIMER	causes	gene	0.60
DEMENTIA	expressed_in	gene	0.60
GENES	expressed_in	gene	0.60
AND	activates	gene	0.60
ASTROCYTES	associated_with	gene	0.60
APOPTOSIS	associated_with	gene	0.60
STROKE	associated_with	gene	0.60
VEGFB	activates	gene	0.60
PDGFRB	activates	gene	0.60
PI3K	activates	gene	0.60
STING	activates	gene	0.60
BCL2L1	associated_with	gene	0.60
MAP2K1	associated_with	gene	0.60
AKT	associated_with	entity	0.60
PERICYTE	interacts_with	gene	0.60
CYTOKINES	interacts_with	gene	0.60
CANCER	activates	gene	0.60
GENES	inhibits	gene	0.60
AREG	associated_with	gene	0.60
MAPK	associated_with	gene	0.60
BMP2	activates	gene	0.60
VEGF	activates	gene	0.60
FGF2	activates	gene	0.60
CD8	activates	gene	0.60
PDGFRB	associated_with	gene	0.60
AKT	activates	gene	0.60
CCL2	associated_with	gene	0.60
HDAC	activates	gene	0.60
VCAM1	associated_with	gene	0.60
CD44	associated_with	gene	0.60
AKT	inhibits	gene	0.60
PIK3R1	inhibits	gene	0.60
AHR	activates	gene	0.60
NOTCH3	activates	gene	0.60
CLDN5	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Digital biomarkers and AI-driven early detection of neurodegeneration

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.756

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Can speech, gait, retinal imaging, sleep, and smartphone data detect neurodegene

closed · Rounds: 4 · Score: 0.95 · 2026-04-06

Related Research

Hypotheses and analyses mentioning ANGPT1 in their description or question text

No additional research found