gene

PTK2B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PTK2B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

379Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

1Experiments

0Debates

Summary

PTK2B is a gene implicated in neurodegeneration research. Key relationships include: contributes to, activates, associated with. Associated with ALS, Als, Leukemia. Connected to 39 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	PTK2B
Full Name	Protein Tyrosine Kinase 2 Beta (Pyk2)
Chromosome	8p21.1
Protein Type	Receptor
Function	is a non-receptor tyrosine kinase that belongs to the focal adhesion kinase (FAK) family.
Primary Expression	Neurons, Microglia, Astrocytes
Molecular Weight	115 kDa
Amino Acids	1009 aa
Exons	34
Pathways	Adaptive Immunity, Amyloid, Complement, glutamate signaling
UniProt ID	Q14289
NCBI Gene ID	5793
Ensembl ID	ENSG00000163599
OMIM	607350
GeneCards	PTK2B
Human Protein Atlas	PTK2B
Associated Diseases	Aging, Als, Alzheimer, Alzheimer's disease, disease
Interactions	ABCA7, ABL1, ABL2, Actin, ALZHEIMER, ALZHEIMER DISEASE
KG Connections	379 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: PTK2B — AlphaFold Q14289 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    PTK2B["PTK2B"]
    Leukemia{"Leukemia"}
    PTK2B -->|"activates"| Leukemia
    Als{"Als"}
    PTK2B -->|"activates"| Als
    PTK2B -->|"interacts with"| Als
    ALS{"ALS"}
    PTK2B -->|"activates"| ALS
    IL7R["IL7R"]
    PTK2B -->|"contributes to"| IL7R
    JAK2["JAK2"]
    PTK2B -->|"contributes to"| JAK2
    PDGFRB["PDGFRB"]
    PTK2B -->|"contributes to"| PDGFRB
    ETV6["ETV6"]
    PTK2B -->|"activates"| ETV6
    NTRK3["NTRK3"]
    PTK2B -->|"contributes to"| NTRK3
    CSF1R["CSF1R"]
    PTK2B -->|"contributes to"| CSF1R
    ABL1["ABL1"]
    PTK2B -->|"contributes to"| ABL1
    GENES["GENES"]
    PTK2B -->|"activates"| GENES
    TYK2["TYK2"]
    TYK2 -->|"contributes to"| PTK2B
    ABL2["ABL2"]
    ABL2 -->|"contributes to"| PTK2B
    NTRK3 -->|"contributes to"| PTK2B
    ABL1 -->|"contributes to"| PTK2B
    PIK3CA["PIK3CA"]
    PIK3CA -->|"associated with"| PTK2B
    CSF1R -->|"contributes to"| PTK2B
    EPOR["EPOR"]
    EPOR -->|"contributes to"| PTK2B
    TSLP["TSLP"]
    TSLP -->|"contributes to"| PTK2B
    GENES -->|"activates"| PTK2B
    JAK2 -->|"contributes to"| PTK2B
    style PTK2B fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (225)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:PTK2B	data_in	dataset_row	0.00
ds-f50762b67605	provides_data_for	dataset	1.00
ds-db4a006ea647	provides_data_for	dataset	1.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
Als	associated_with	disease	0.65
ALS	regulates	disease	0.65
Inflammation	phosphorylates	disease	0.65
Alzheimer	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Als	activates	disease	0.65
Leukemia	activates	disease	0.65
Als	interacts_with	disease	0.65
Alzheimer	encodes	disease	0.65
ALS	activates	disease	0.65
Alzheimer	causes	disease	0.65
Aging	causes	disease	0.65
Neurodegeneration	interacts_with	disease	0.65
Tauopathy	phosphorylates	disease	0.65
Alzheimer	regulates	disease	0.65
Alzheimer	activates	disease	0.65
Als	regulates	disease	0.65
TAU PATHOLOGY	activates	gene	0.60
Phagocytosis	associated_with	pathway	0.60
Amyloid	activates	pathway	0.60
Complement	activates	pathway	0.60
Microglia	associated_with	cell_type	0.60
Neuron	activates	cell_type	0.60
Lipid Metabolism	associated_with	pathway	0.60
Immune Response	associated_with	pathway	0.60
GSK3	phosphorylates	gene	0.60
T Cell	phosphorylates	cell_type	0.60
Neuron	phosphorylates	cell_type	0.60
AGING	causes	gene	0.60
Neuron	interacts_with	cell_type	0.60
IL7R	contributes_to	gene	0.60
JAK2	contributes_to	gene	0.60
PDGFRB	contributes_to	gene	0.60
NTRK3	contributes_to	gene	0.60
CSF1R	contributes_to	gene	0.60
CD2AP	interacts_with	gene	0.60
APOE	interacts_with	gene	0.60
CR1	interacts_with	gene	0.60
BIN1	interacts_with	gene	0.60
NME8	interacts_with	gene	0.60
ZCWPW1	interacts_with	gene	0.60
ABCA7	interacts_with	gene	0.60
GAB2	interacts_with	gene	0.60
MS4A4E	interacts_with	gene	0.60
CLU	interacts_with	gene	0.60
TOMM40	interacts_with	gene	0.60

Incoming (154)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:PTK2B	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
ds-f50762b67605	data_in	dataset	1.00
ds-db4a006ea647	data_in	dataset	1.00
ALZHEIMER DISEASE	associated_with	gene	0.80
CSF1R	activates	entity	0.60
IL7R	activates	entity	0.60
JAK2	activates	entity	0.60
NTRK3	activates	entity	0.60
PDGFRB	activates	entity	0.60
CD8	activates	gene	0.60
LRP1	activates	gene	0.60
SPI1	associated_with	gene	0.60
TMEM106B	associated_with	gene	0.60
CASS4	interacts_with	gene	0.60
CD33	interacts_with	gene	0.60
CELF1	interacts_with	gene	0.60
EPHA1	interacts_with	gene	0.60
FERMT2	interacts_with	gene	0.60
INPP5D	interacts_with	gene	0.60
MEF2C	interacts_with	gene	0.60
ABL1	contributes_to	gene	0.60
ALZHEIMER	associated_with	gene	0.60
GENES	associated_with	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
CRLF2	contributes_to	gene	0.60
FLT3	contributes_to	gene	0.60
HLA	interacts_with	gene	0.60
PICALM	associated_with	gene	0.60
TYK2	contributes_to	gene	0.60
IL7R	contributes_to	gene	0.60
PDGFRB	contributes_to	gene	0.60
PLD3	associated_with	gene	0.60
ABCA7	associated_with	gene	0.60
SORL1	associated_with	gene	0.60
TREM2	associated_with	gene	0.60
CASS4	associated_with	gene	0.60
NME8	associated_with	gene	0.60
EPHA1	associated_with	gene	0.60
CELF1	associated_with	gene	0.60
MEF2C	associated_with	gene	0.60
MS4A6A	implicated_in	gene	0.60
CR1	causes	gene	0.60
EPOR	contributes_to	gene	0.60
TSLP	contributes_to	gene	0.60
GENES	activates	gene	0.60
PHAGOCYTOSIS	associated_with	entity	0.60
ALZHEIMER DISEASE	activates	gene	0.60
TAU PATHOLOGY	activates	gene	0.60
ABL1	activates	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Tau-trafficking GWAS loci define a druggable PTK2B endocytos	0.600	Alzheimer's disease	-

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
12 newly identified AD-associated genes show prior evidence linking th	computational	Alzheimer's disease	0.500	0.00	in_vitro	extracted	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PTK2B in their description or question text

No additional research found