protein 1,771 words KG: PPAR
Contents

PPAR (Peroxisome Proliferator-Activated Receptor)

🔬 Protein Info
Gene SymbolPPAR
Full NamePPAR (Peroxisome Proliferator-Activated Receptor)
AliasesPeroxisome Proliferator-Activated Receptor
Protein TypeProtein
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressionneurons, astrocytes, microglia, and oligodendrocytes, where they modulate critical processes including neuroinflammation, mit
PathwaysApoptosis, Autophagy, Differentiation, Epigenetic, Lipid Metabolism
UniProt IDSearch UniProt
GeneCardsPPAR
Human Protein AtlasPPAR
Associated DiseasesAD, Als, Alzheimer, AMI, ARDS
Known Drugs/Compoundskaempferol, SDHHQ
InteractionsABCA1, ABCA7, ABCB1, ACSL4, Actin, AEP
KG Connections989 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (64)

ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.87
Adenosine-Astrocyte Metabolic Reset
Score: 0.73
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.90
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.86
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
SASP-Driven Aquaporin-4 Dysregulation
Score: 0.78
Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.78
Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu
Score: 0.77
SASP-Mediated Cholinergic Synapse Disruption
Score: 0.76
Circadian Clock-Autophagy Synchronization
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
Transcriptional Autophagy-Lysosome Coupling
Score: 0.76
Multi-Modal Stress Response Harmonization
Score: 0.76
Senescence-Activated NAD+ Depletion Rescue
Score: 0.76
Senescent Cell Mitochondrial DNA Release
Score: 0.74
PARP1 Inhibition Therapy
Score: 0.74
Aquaporin-4 Polarization Rescue
Score: 0.73
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
pg 1/4Next →

Related Analyses (28)

Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

Related Experiments (4)

TUG C-terminal fragment nuclear interactions
exploratory · proposed · Score: 0.85
Pathway analysis of aminophylline effects on neuronal signal
exploratory · proposed · Score: 0.70
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (7)

ABCA7 (Redirect)
redirect · KG edge: activates
ABCB1 (MDR1) - ATP Binding Cassette Subfamily B Member
gene · KG edge: expressed_in
ACE Gene
gene · KG edge: regulates
ACSL4 Gene - Acyl-CoA Synthetase Long Chain Family Memb
gene · KG edge: inhibits
ALOX15 - Arachidonate 15-Lipoxygenase
gene · KG edge: inhibits

Knowledge Graph (12 edges)

PPAR implicated_in obesity
PPAR implicated_in ARDS
PPAR implicated_in degenerative disease
PPAR implicated_in neurodegenerative disease
CLDN1 activates PPAR
PPAR activates TNF
PPAR activates OCLN
PPAR inhibits MLCK
AQP4 activates PPAR
PRKN activates PPAR

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