concept

PPAR-Γ

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PPAR-Γ: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

273Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

PPAR-Γ is a concept in neurodegeneration research. Key relationships include: activates, contributes to, inhibits. Associated with ALS, Als, Alzheimer. Connected to 136 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	PPAR-Γ
Key Genes/Proteins	AKT, ALZHEIMER, ALZHEIMER'S DISEASE, AMPK, AMYLOID, AND
Related Diseases	Als, ALS, Alzheimer
Related Pathways	Akt, Amyloid, Angiogenesis, Apoptosis

Pathway Diagram

graph TD
    PPAR__["PPAR-Gamma"]
    PPAR__ -->|"inhibits"| Als["Als"]
    PPAR__ -->|"inhibits"| Ms["Ms"]
    PPAR__ -->|"inhibits"| Tumor["Tumor"]
    PPAR__ -->|"contributes to"| Inflammation["Inflammation"]
    PPAR__ -->|"contributes to"| Alzheimer["Alzheimer"]
    PPAR__ -->|"contributes to"| Neurodegeneration["Neurodegeneration"]
    PPAR__ -->|"contributes to"| Neuroinflammation["Neuroinflammation"]
    PPAR__ -->|"contributes to"| Dementia["Dementia"]
    CD4["CD4"] -->|"inhibits"| PPAR__
    CYTOKINES["CYTOKINES"] -->|"inhibits"| PPAR__
    FOXP3["FOXP3"] -->|"inhibits"| PPAR__
    NF__B["NF-KappaB"] -->|"inhibits"| PPAR__
    TNF["TNF"] -->|"inhibits"| PPAR__
    STAT3["STAT3"] -->|"inhibits"| PPAR__
    IL_6["IL-6"] -->|"inhibits"| PPAR__
    MICROGLIA["MICROGLIA"] -->|"contributes to"| PPAR__
    MTOR["MTOR"] -->|"contributes to"| PPAR__
    PHAGOCYTOSIS["PHAGOCYTOSIS"] -->|"inhibits"| PPAR__

Outgoing (159)

Target	Relation	Type	Str
NF-κB	inhibits	protein	0.80
NF-κB	modulates	pathway	0.80
Tumor	activates	disease	0.75
Inflammation	activates	disease	0.75
Diabetes	activates	disease	0.75
PPAR	activates	gene	0.70
neurodegeneration	protects_against	process	0.70
neurodegenerative disease	treats	disease	0.70
gene transcription	regulates	process	0.70
PGC-1α	interacts_with	protein	0.70
Ms	activates	disease	0.65
ALS	associated_with	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Atherosclerosis	activates	disease	0.65
Diabetes	therapeutic_target	disease	0.65
Fibrosis	activates	disease	0.65
Cardiac	activates	disease	0.65
Multiple Sclerosis	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Autoimmune	associated_with	disease	0.65
Ms	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Ms	expressed_in	disease	0.65
Fibrosis	contributes_to	disease	0.65
Als	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Tumor	inhibits	disease	0.65
Neurodegeneration	protects_against	disease	0.65
Cardiovascular	activates	disease	0.65
Cancer	activates	disease	0.65
Sepsis	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Als	associated_with	disease	0.65
Hepatitis	activates	disease	0.65
Obesity	activates	disease	0.65
Cirrhosis	activates	disease	0.65
Hypertension	activates	disease	0.65
Als	activates	disease	0.65
Dementia	contributes_to	disease	0.65
Tumor	contributes_to	disease	0.65
Obesity	regulates	disease	0.65
Neuroinflammation	activates	disease	0.65
Alzheimer	contributes_to	disease	0.65
Parkinson	activates	disease	0.65
ALS	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Neurodegeneration	contributes_to	disease	0.65
Neuroinflammation	contributes_to	disease	0.65
Epigenetic	regulates	pathway	0.60

Incoming (114)

Source	Relation	Type	Str
Betulinic Acid	activates	chemical	0.80
PPARGC1A	associated_with	gene	0.80
FKBP5	regulates	gene	0.80
PPARG	encodes	gene	0.70
NRF2	activates	gene	0.70
PPAR	activates	gene	0.70
AQP4	activates	gene	0.60
AQUAPORIN-4	associated_with	gene	0.60
ASTROCYTE	activates	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
PROINFLAMMATORY CYTOKINES	associated_with	gene	0.60
INFLAMMATION	associated_with	gene	0.60
PPAR	inhibits	gene	0.60
DEMENTIA	contributes_to	gene	0.60
ALZHEIMER	contributes_to	gene	0.60
P38	contributes_to	gene	0.60
AMYLOID	inhibits	gene	0.60
ASTROCYTE	contributes_to	gene	0.60
APOPTOSIS	activates	gene	0.60
CLOCK	regulates	gene	0.60
BAX	therapeutic_target	gene	0.60
BCL2	therapeutic_target	gene	0.60
CASPASE3	therapeutic_target	gene	0.60
PPAR	expressed_in	gene	0.60
MTOR	therapeutic_target	gene	0.60
NEURODEGENERATION	protects_against	gene	0.60
AND	activates	gene	0.60
MICROGLIA	contributes_to	gene	0.60
MTOR	contributes_to	gene	0.60
PHAGOCYTOSIS	inhibits	gene	0.60
NEURODEGENERATION	contributes_to	gene	0.60
ALZHEIMER'S DISEASE	contributes_to	gene	0.60
AKT	contributes_to	gene	0.60
ASTROCYTES	contributes_to	gene	0.60
TAU	contributes_to	gene	0.60
GLUT4	activates	gene	0.60
HMGB2	inhibits	gene	0.60
SIRT1	inhibits	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
AMPK	activates	gene	0.60
PI3K	therapeutic_target	gene	0.60
INSULIN RESISTANCE	contributes_to	gene	0.60
OXIDATIVE STRESS	contributes_to	gene	0.60
CYTOKINES	associated_with	gene	0.60
ERK1	inhibits	gene	0.60
MAPK	activates	gene	0.60
PPARA	activates	gene	0.60
EGFR	activates	gene	0.60
MAPK1	activates	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PPAR-Γ in their description or question text

No additional research found