gene

NGF

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NGF: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1013Connections

1Hypotheses

3Analyses

50Outgoing

50Incoming

0Experiments

3Debates

Summary

Nerve Growth Factor - founding member of neurotrophin family for neuronal survival

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🧬 Gene Info

Gene Symbol	NGF
Full Name	Nerve Growth Factor
Chromosome	1p13.1
Protein Family	Neurotrophin family
Primary Expression	Primarily in nociceptive sensory neurons, cholinergic basal forebrain neurons, sympathetic ganglia
Molecular Weight	30 kDa
Amino Acids	120 aa
Exons	3
Pathways	PI3K, MAPK
UniProt ID	P01138
NCBI Gene ID	4800
Ensembl ID	ENSG00000111665
OMIM	162030
GeneCards	NGF
Human Protein Atlas	NGF
Associated Diseases	Als, Alzheimer, Alzheimer's disease, Amyotrophic Lateral Sclerosis, ANGIOGENESIS
Known Drugs/Compounds	aducanumab, lecanemab, metformin
Interactions	ACHE, Actin, ADRB2, AGING, Akt, AKT
KG Connections	772 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: NGF — AlphaFold P01138 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (9)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    NGF["NGF"]
    NGF -->|"downregulates"| PRDM4["PRDM4"]
    NGF -->|"activates"| Als["Als"]
    NGF -->|"expressed in"| Ischemia["Ischemia"]
    NGF -->|"activates"| Ms["Ms"]
    NGF -->|"regulates"| Inflammation["Inflammation"]
    NGF -->|"target for"| Diabetes["Diabetes"]
    NGF -->|"target for"| Neurodegeneration["Neurodegeneration"]
    CHAT["CHAT"] -->|"regulates"| NGF
    TRKA["TRKA"] -->|"interacts"| NGF
    NRP1["NRP1"] -->|"activates"| NGF
    BDNF["BDNF"] -->|"activates"| NGF
    CHR2["CHR2"] -->|"regulates"| NGF
    GFAP["GFAP"] -->|"activates"| NGF
    TNF["TNF"] -->|"regulates"| NGF
    SLC7A11["SLC7A11"] -->|"activates"| NGF
    GAIN["GAIN"] -->|"activates"| NGF
    GPX4["GPX4"] -->|"activates"| NGF

Outgoing (557)

Target	Relation	Type	Str
Neurodegeneration	activates	disease	0.95
NEUROTROPHINS	component_of	protein	0.95
Nervous System Development	regulates	process	0.90
neurons	expressed_in	cell_type	0.90
dorsal root ganglia	expressed_in	cell_type	0.85
Neurite Outgrowth	promotes	phenotype	0.85
neurotrophin signaling	participates_in	pathway	0.85
ERK	activates	protein	0.85
hippocampus	expressed_in	brain_region	0.80
neurons	activates	cell_type	0.80
Hepatocellular Carcinoma	biomarker_for	disease	0.75
Diabetes	activates	disease	0.75
Obesity	activates	disease	0.75
Inflammation	activates	disease	0.75
Senescence	activates	disease	0.75
Als	treats	disease	0.75
Als	activates	disease	0.75
Alzheimer's disease	biomarker_for	disease	0.70
Oxidative Stress	activates	pathway	0.70
neurodegeneration	associated_with	disease	0.70
oxidative stress response	participates_in	pathway	0.70
Alzheimer's disease	treats	disease	0.70
Lipid Metabolism	activates	pathway	0.70
Alzheimer's disease	interacts_with	disease	0.70
neurons	associated_with	cell_type	0.70
Neurodegeneration	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Diabetes	therapeutic_target	disease	0.65
Insulin Resistance	activates	disease	0.65
Als	regulates	disease	0.65
Ms	inhibits	disease	0.65
Infection	activates	disease	0.65
Tumor	activates	disease	0.65
Dystonia	activates	disease	0.65
Alzheimer	treats	disease	0.65
Inflammation	treats	disease	0.65
Dementia	treats	disease	0.65
Metabolic Syndrome	activates	disease	0.65
Depression	inhibits	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Ms	regulates	disease	0.65
Cancer	regulates	disease	0.65
Multiple Sclerosis	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Schizophrenia	regulates	disease	0.65
Alzheimer	activates	disease	0.65
Ischemia	expressed_in	disease	0.65
Neuroinflammation	treats	disease	0.65
Als	interacts_with	disease	0.65
Dementia	regulates	disease	0.65

Incoming (456)

Source	Relation	Type	Str
ALZHEIMER'S DISEASE	associated_with	disease	1.00
BDNF	associated_with	gene	0.90
Optogenetic Stimulation	upregulates	mechanism	0.90
ChR2	upregulates	protein	0.85
FB23	upregulates	drug	0.85
PARKINSON'S DISEASE	associated_with	disease	0.82
NEURODEGENERATION	associated_with	concept	0.82
NEURODEGENERATION	activates	gene	0.80
CYTOKINES	activates	gene	0.80
AMYLOID	associated_with	gene	0.74
BDNF	activates	gene	0.74
CHAT	regulates	gene	0.70
GDNF	regulates	gene	0.70
BDNF	protects_against	gene	0.70
AKT	associated_with	gene	0.66
ALS	associated_with	disease	0.66
GDNF	associated_with	gene	0.65
NOREPINEPHRINE	activates	phenotype	0.65
ULK1	activates	gene	0.65
SLC24A2	activates	gene	0.60
BAG1	regulates	gene	0.60
NBN	regulates	gene	0.60
TAU	treats	gene	0.60
PRKAA1	activates	gene	0.60
PDE4C	activates	gene	0.60
TNF	activates	gene	0.60
NPY	activates	gene	0.60
CRH	activates	gene	0.60
PPARG	activates	gene	0.60
TNF	treats	gene	0.60
APOE	regulates	gene	0.60
P2RY12	regulates	gene	0.60
OVERVIEW	activates	gene	0.60
TRKA	activates	gene	0.60
NRF2	activates	gene	0.60
MECP2	associated_with	gene	0.60
NOX1	regulates	gene	0.60
STAT3	activates	gene	0.60
CHMP3	regulates	gene	0.60
JNK	activates	gene	0.60
MMP2	activates	gene	0.60
CX3CR1	regulates	gene	0.60
ARC	activates	gene	0.60
DISC1	regulates	gene	0.60
PTEN	activates	gene	0.60
TRKA	therapeutic_target	gene	0.60
IL6	activates	gene	0.60
CHR2	activates	gene	0.60
MMP9	activates	gene	0.60
SORLA	associated_with	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Basal forebrain NGF/TrkA trophic failure is an upstream trig	0.610	neurodegeneration	What determines the temporal sequence of

Mentioning Analyses (3)

Scientific analyses that reference this entity

Epigenetic reprogramming in aging neurons

neurodegeneration | 2026-04-04 | 9 hypotheses Top: 0.914

Epigenetic clocks and biological aging in neurodegeneration

neurodegeneration | 2026-04-01 | 6 hypotheses Top: 0.710

Neuroinflammation resolution mechanisms and pro-resolving mediators

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.784

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (3)

Multi-agent debates referencing this entity

Epigenetic reprogramming in aging neurons

closed · Rounds: 4 · Score: 0.95 · 2026-04-10

SPMs (resolvins, protectins, maresins) from omega-3s may promote inflammation re

closed · Rounds: 4 · Score: 0.83 · 2026-04-06

Epigenetic clocks and biological aging in neurodegeneration

closed · Rounds: 4 · Score: 0.93 · 2026-04-06

Related Research

Hypotheses and analyses mentioning NGF in their description or question text

No additional research found

NGF

Understanding Entity Pages

Summary

Wiki Pages (9)

PC12 Cell Line

NGF Gene

Nerve Growth Factor (NGF)

NGFR Gene

NGF Protein

NGF Neurons

NGF (Redirect)

NGFR (p75NTR) Protein

Nerve Growth Factor (NGF) Responsive Neurons

Pathway Diagram

Outgoing (557)

Incoming (456)

Targeting Hypotheses (1)

Mentioning Analyses (3)

Epigenetic reprogramming in aging neurons

Epigenetic clocks and biological aging in neurodegeneration

Neuroinflammation resolution mechanisms and pro-resolving mediators

Experiments (0)

Related Papers (0)

Debates (3)

Epigenetic reprogramming in aging neurons

SPMs (resolvins, protectins, maresins) from omega-3s may promote inflammation re

Epigenetic clocks and biological aging in neurodegeneration

Related Research