concept

TREHALOSE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TREHALOSE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

227Connections

0Hypotheses

2Analyses

50Outgoing

50Incoming

0Experiments

2Debates

Summary

TREHALOSE is a concept in neurodegeneration research. Key relationships include: activates, expressed in. Associated with Als, Amyotrophic Lateral Sclerosis, Ataxia. Connected to 98 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	TREHALOSE
Key Genes/Proteins	AKT, ALS, AMPK, AMYLOID, AMYOTROPHIC LATERAL SCLEROSIS, AND
Related Diseases	AGING, Als, Amyotrophic Lateral Sclerosis, APOPTOSIS, Ataxia
Related Pathways	Akt

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Trehalose for Neurodegenerative Diseases

therapeutic · 1790 words

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Pathway Diagram

graph TD
    TREHALOSE["TREHALOSE"]
    TREHALOSE -->|"activates"| TFEB["TFEB"]
    TREHALOSE -->|"activates"| autophagy["autophagy"]
    TREHALOSE -->|"treats"| multiple_sclerosis["multiple sclerosis"]
    TREHALOSE -->|"activates"| remyelination["remyelination"]
    TREHALOSE -->|"activates"| Atherosclerosis["Atherosclerosis"]
    TREHALOSE -->|"activates"| Huntington["Huntington"]
    TREHALOSE -->|"activates"| Spinocerebellar_Ataxia["Spinocerebellar Ataxia"]
    TREHALOSE -->|"activates"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    TREHALOSE -->|"activates"| Parkinson["Parkinson"]
    P62["P62"] -->|"activates"| TREHALOSE
    SOD1["SOD1"] -->|"activates"| TREHALOSE
    MAP1LC3B["MAP1LC3B"] -->|"activates"| TREHALOSE
    LGALS3["LGALS3"] -->|"activates"| TREHALOSE
    MCOLN1["MCOLN1"] -->|"activates"| TREHALOSE
    STIP1["STIP1"] -->|"activates"| TREHALOSE
    AUTOPHAGY["AUTOPHAGY"] -->|"activates"| TREHALOSE
    ALS["ALS"] -->|"activates"| TREHALOSE
    SQSTM1["SQSTM1"] -->|"activates"| TREHALOSE
    PPARGC1A["PPARGC1A"] -->|"activates"| TREHALOSE

Outgoing (160)

Target	Relation	Type	Str
Autophagy	activates	process	0.95
TFEB	activates	gene	0.95
AUTOPHAGY	promotes	process	0.95
Autophagy	associated_with	process	0.95
TFEB	activates	gene	0.95
TFEB	activates	protein	0.90
Lysosomal Membrane Permeabilization	associated_with	process	0.90
NEURODEGENERATION	protects_against	entity	0.85
Motoneuron Degeneration	protects_against	disease	0.85
LYSOSOME	modulates	entity	0.85
autophagy pathway	modulates	pathway	0.85
Autophagy-Related Genes	upregulates	gene	0.80
Motoneuron Degeneration	treats	disease	0.80
Neurodegenerative Diseases	associated_with	disease	0.80
TFEB	targets	gene	0.75
ALS	treats	disease	0.75
Autophagy	upregulates	process	0.75
Neurodegenerative Diseases	treats	disease	0.75
GDNF	destabilizes	gene	0.70
GDNF	protects_against	gene	0.70
FOXO3	activates	gene	0.70
multiple sclerosis	treats	disease	0.70
autophagy induction	causes (induces autophagy through multiple pathways includ)	mechanism	0.70
autophagy	activates	process	0.70
AUTOPHAGY	activates	gene	0.70
TAU	activates	protein	0.70
remyelination	activates	process	0.70
Autophagy	activates	pathway	0.70
Mtor	activates	pathway	0.70
tau pathology	reduces	phenotype	0.70
TFEB	treats	gene	0.65
Neuroblastoma	activates	disease	0.65
Atherosclerosis	activates	disease	0.65
Als	activates	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Parkinson	activates	disease	0.65
JNK	activates	gene	0.65
JNK	inhibits	gene	0.65
PARP1	activates	gene	0.65
PARP1	inhibits	gene	0.65
Ataxia	activates	disease	0.65
OXIDATIVE STRESS	inhibits	phenotype	0.65
Neurodegeneration	activates	disease	0.65
MTOR	inhibits	gene	0.65
MITOCHONDRIAL DYSFUNCTION	inhibits	phenotype	0.65
OXIDATIVE STRESS	activates	phenotype	0.65
ERK	regulates	gene	0.65
Huntington	activates	disease	0.65
Spinocerebellar Ataxia	activates	disease	0.65
PPP3	activates	gene	0.64

Incoming (67)

Source	Relation	Type	Str
NEURON	causes	cell_type	0.65
TFEB	inhibits	gene	0.65
TFEB	degrades	gene	0.65
NEURON	activates	cell_type	0.65
TFEB	promotes	gene	0.65
NEURODEGENERATIVE DISORDERS	activates	gene	0.60
STUB1	activates	gene	0.60
SOD1	activates	gene	0.60
MAP1LC3B	activates	gene	0.60
LGALS3	activates	gene	0.60
MCOLN1	activates	gene	0.60
STIP1	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
ALS	activates	gene	0.60
SQSTM1	activates	gene	0.60
PPARGC1A	activates	gene	0.60
HUNTINGTON	activates	gene	0.60
PARKINSON	activates	gene	0.60
P62	activates	gene	0.60
ATG	activates	gene	0.60
HSPB8	activates	gene	0.60
TREH	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
ATG12	activates	gene	0.60
TARDBP	activates	gene	0.60
PPP3CB	activates	gene	0.60
CTSB	activates	gene	0.60
DNA	activates	gene	0.60
GENES	activates	gene	0.60
LAMP1	activates	gene	0.60
GAPDH	activates	gene	0.60
HSPA8	activates	gene	0.60
ATG10	activates	gene	0.60
GLA	activates	gene	0.60
MTOR	activates	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	activates	gene	0.60
CALCINEURIN	activates	gene	0.60
BECN1	activates	gene	0.60
TFEB	activates	gene	0.60
LAMP2A	activates	gene	0.60
TPP1	activates	gene	0.60
PPP3	activates	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
BCL2	activates	gene	0.60
BAG3	activates	gene	0.60
AND	activates	gene	0.60
MTORC1	activates	gene	0.60
RNA	activates	gene	0.60
Autophagy	activates	process	0.50
PROTEIN AGGREGATION	associated_with	phenotype	0.50