cell_type

DAM microglia

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DAM microglia: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

164Connections

1Hypotheses

0Analyses

19Outgoing

50Incoming

10Experiments

0Debates

No summary available yet.

View on Wiki →

No AI portrait yet

🧫 Cell Type Info

Cell Type	DAM microglia
Also Known As	DAM, Activated microglia, AD-associated microglia, ARM (activated response microglia)
Key Pathways	TREM2/DAP12 signaling, PI3K/AKT/mTOR (downstream of TREM2), Phagocytosis (Abeta/tau), Lipid metabolism upregulation, Complement activation
Associated Diseases	Alzheimer's disease (primary), Frontotemporal dementia, ALS, Multiple sclerosis, Parkinson's disease
Related Genes	ADAM10, ALS, APOE, APOE4, ATP, C3
Linked Hypotheses	316 hypotheses

Pathway Diagram

graph TD
    DAM_microglia["DAM microglia"] -->|"active in"| senescence["senescence"]
    style senescence fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    DAM_microglia["DAM microglia"] -->|"active in"| oxidative_stress_response["oxidative stress response"]
    style oxidative_stress_response fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    DAM_microglia["DAM microglia"] -->|"active in"| unfolded_protein_response["unfolded protein response"]
    style unfolded_protein_response fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    DAM_microglia["DAM microglia"] -->|"active in"| mitochondrial_function["mitochondrial function"]
    style mitochondrial_function fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    DAM_microglia["DAM microglia"] -->|"active in"| autophagy_pathway["autophagy pathway"]
    style autophagy_pathway fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    DAM_microglia["DAM microglia"] -->|"active in"| complement_cascade["complement cascade"]
    style complement_cascade fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    DAM_microglia["DAM microglia"] -->|"active in"| NAD__metabolism["NAD+ metabolism"]
    style NAD__metabolism fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    TREM2["TREM2"] -->|"expressed in"| DAM_microglia["DAM microglia"]
    style TREM2 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    DNA["DNA"] -->|"expressed in"| DAM_microglia["DAM microglia"]
    style DNA fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    PINK1["PINK1"] -->|"expressed in"| DAM_microglia["DAM microglia"]
    style PINK1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    C3["C3"] -->|"expressed in"| DAM_microglia["DAM microglia"]
    style C3 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    APOE4["APOE4"] -->|"expressed in"| DAM_microglia["DAM microglia"]
    style APOE4 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style DAM_microglia fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (19)

Target	Relation	Type	Str
ubiquitin-proteasome	expressed_in	pathway	0.85
senescence	active_in	pathway	0.85
oxidative stress response	active_in	pathway	0.85
unfolded protein response	active_in	pathway	0.85
mitochondrial function	active_in	pathway	0.85
autophagy pathway	active_in	pathway	0.85
complement cascade	active_in	pathway	0.85
epigenetic regulation	active_in	pathway	0.85
NAD+ metabolism	active_in	pathway	0.85
sphingolipid metabolism	active_in	pathway	0.75
pyroptosis	active_in	pathway	0.75
purinergic signaling	active_in	pathway	0.75
insulin signaling	active_in	pathway	0.75
lipid metabolism	active_in	pathway	0.75
circadian regulation	active_in	pathway	0.65
NF-kB signaling	active_in	pathway	0.65
neurotrophin signaling	active_in	pathway	0.55
blood-brain barrier	active_in	pathway	0.55
ferroptosis	active_in	pathway	0.55

Incoming (145)

Source	Relation	Type	Str
37165437	exhibit	paper	0.90
TREM2	activates	protein	0.90
APOE	expressed_in	gene	0.85
APOE4	expressed_in	gene	0.85
TNF	expressed_in	gene	0.85
C3	expressed_in	gene	0.85
GFAP	expressed_in	gene	0.85
NAD	expressed_in	gene	0.85
PINK1	expressed_in	gene	0.85
TDP-43	expressed_in	gene	0.85
TREM2	expressed_in	gene	0.85
DNA	expressed_in	gene	0.85
RNA	expressed_in	gene	0.85
ROS	expressed_in	gene	0.75
ALS	expressed_in	gene	0.75
APOE3	expressed_in	gene	0.75
P2RY12	expressed_in	gene	0.75
ADAM10	expressed_in	gene	0.75
IL-6	expressed_in	gene	0.75
NLRP3	expressed_in	gene	0.75
ATP	expressed_in	gene	0.75
AQP4	expressed_in	gene	0.75
YKL-40	expressed_in	gene	0.65
P2X7	expressed_in	gene	0.65
TFEB	expressed_in	gene	0.65
C1QA	expressed_in	gene	0.65
SQSTM1	expressed_in	gene	0.65
LAMP1	expressed_in	gene	0.65
CX3CR1	expressed_in	gene	0.65
SOD1	expressed_in	gene	0.65
ADAM17	expressed_in	gene	0.65
AMPK	expressed_in	gene	0.65
TMEM119	expressed_in	gene	0.65
H2AX	expressed_in	gene	0.65
APP	expressed_in	gene	0.65
S100B	expressed_in	gene	0.65
PTEN	expressed_in	gene	0.65
CD68	expressed_in	gene	0.65
PARP1	expressed_in	gene	0.65
EPHB4	expressed_in	gene	0.55
BCL-2	expressed_in	gene	0.55
DRP1	expressed_in	gene	0.55
KDM6A	expressed_in	gene	0.55
FOXO3	expressed_in	gene	0.55
AHR	expressed_in	gene	0.55
TLR4	expressed_in	gene	0.55
BDNF	expressed_in	gene	0.55
CLDN5	expressed_in	gene	0.55
OCLN	expressed_in	gene	0.55
TAR	expressed_in	gene	0.55

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Cell-Type Specific TREM2 Upregulation in DAM Microglia	0.761	Alzheimer's Disease	SEA-AD Gene Expression Profiling — Allen

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (10)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Model	Status	Est. Cost
Anti-ASC antibody intracerebroventricular injection in APP/PS1 mice	validation	Alzheimer's disease	0.950	APP/PS1 transgenic mice (8 mon	proposed	N/A
Curcumin-Licorice Combination in D-galactose/Sodium Nitrite AD Model	validation	Alzheimer's disease	0.950	C57BL/6 mice	proposed	N/A
SPP1 upregulation in perivascular cells in AD mouse models	exploratory	Alzheimer's disease	0.900	AD mouse models	proposed	N/A
Tet2 modulation in Aβ42-injured mouse hippocampal neurons	exploratory	Alzheimer's disease	0.900	primary mouse hippocampal neur	proposed	N/A
AAV-mediated Tet2 modulation in 2×Tg-AD mice behavioral study	validation	Alzheimer's disease	0.900	young APPswe/PSEN1 double-tran	proposed	N/A
Cerebrovascular function analysis in CD2AP mutant mice	validation	Alzheimer's disease	0.900	mice	proposed	N/A
Cerebral blood flow regulation in CD2AP mutant mice	validation	Alzheimer's disease	0.880	mice	proposed	N/A
Abeta-induced cell death and aggregation in GD3S-deficient neurons	exploratory	Alzheimer's disease	0.850	primary neurons and astrocytes	proposed	N/A
Generation of Aβ-specific Tregs using CRISPR-Cas9	exploratory	Alzheimer's disease	0.850	engineered Tregs	proposed	N/A
Cell-cell interaction analysis of perivascular-microglial crosstalk	exploratory	Alzheimer's disease	0.800	AD mouse models	proposed	N/A

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Transcriptomic cytoarchitecture reveals principles of human neocortex organizati [PMID:37824655]	Jorstad NL, Close J, Johansen N, Yanny A	Science	2023	186
Integrated multimodal cell atlas of Alzheimer’s disease [PMID:37292694]	Gabitto MI, Travaglini KJ, Rachleff VM,	Research Square	2023	63
Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2- [PMID:31932797]	Zhou Y, Song WM, Andhey PS, Swain A, Lev	Nat Med	2020	1
Moderate Effects of the Arginine to Histidine R47H Variant of the Triggering Rec [PMID:41890852]	["Ramirez G", "Hernandez D", "Teal A", "	Research square	2026	0
Increased plasma soluble TREM2 levels in non-Alzheimer's dementia. [PMID:41920402]	Güven Gamze; Gezegen Haşim; &	Acta neurologica Belgica	2026	0
AI-guided design of cyclic peptide binders targeting TREM2 using CycleRFdiffusio [PMID:41435973]	Cho S, Zhu R, Kuncewicz K, Duan H, Gabr	Bioorg Med Chem Lett	2026	0
ITAM-Syk signaling mediates the rebound phenomenon after anti-RANKL antibody dis [PMID:41490759]	Ishizu H, Hasegawa T, Shimizu T, Yamamot	Bone	2026	0
Oxaliplatin-artesunate conjugate intensifies suppression on colorectal cancer by [PMID:41520444]	Tan Y, Yang T, Jiang S, Li S, Cai L et a	J Inorg Biochem	2026	0
Loss of Triggering Receptor Expressed on Myeloid Cells 2 Impairs Microglial Func [PMID:41643896]	Chen G, Wang Z, Zhao C, Wang C, Li Y et	Am J Pathol	2026	0
Microglial metabolic reprogramming in Alzheimer's disease: Pathways, mechanisms, [PMID:41651180]	Yang FG, Yang H, Han SW, Wang JT, Gao W	Ageing Res Rev	2026	0
Plant-derived bioactive compounds modulate the gut microbiota in Alzheimer's dis [PMID:41678917]	Xue D, Hu X, Li R, Sun T, Qian S et al.	Phytomedicine	2026	0
Triggering Receptor Expressed on Myeloid Cells-2 Regulates Innate Lymphoid Cell [PMID:41928407]	Shen HC, Chen NJ, Sun CY, Yu WK, Su VY e	Kaohsiung J Med Sci	2026	0
TREM2 deficiency delays postnatal microglial maturation and synaptic pruning, le [PMID:41930604]	Yang HC, Deng YS, Zhang J, Zhang T, Song	J Alzheimers Dis	2026	0
Population-scale burden analysis of rare damaging coding variants identifies nov [PMID:41867223]	Le Guen Y, Peña-Tauber A, Pulgrossi RC,	medRxiv : the preprint server	2026	0
TREM2 as a possible link between Alzheimer's disease and diabetes mellitus. [PMID:41862118]	Chen W, Huang N, Huang W, Wang M, Luo Y,	Experimental neurology	2026	0
The microglial TREM2 receptor programs hippocampal development in a mouse model [PMID:41887542]	Ahmed S, Bowers C, Munoz-Martin J, Jamwa	Brain, behavior, and immunity	2026	0
Neuroinflammation and Alzheimer's disease: Unravelling the molecular mechanisms. [PMID:40938771]	Kakkar A, Singh H, Singh BK, Kumar A, Mi	Journal of Alzheimer's disease	2025	0
Dehydroervatamine as a promising novel TREM2 agonist, attenuates neuroinflammati [PMID:39609160]	Li L, Xu N, He Y, Tang M, Yang B, Du J,	Neurotherapeutics : the journa	2025	0
TREM2 regulates microglial lipid droplet formation and represses post-ischemic b [PMID:38042110]	Wei W, Zhang L, Xin W, Pan Y, Tatenhorst	Biomedicine & pharmacotherapy	2024	0
Defects in lysosomal function and lipid metabolism in human microglia harboring [PMID:37115208]	Filipello F, You SF, Mirfakhar FS, Mahal	Acta neuropathologica	2023	0

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DAM microglia in their description or question text

No additional research found