Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CEREBELLUM: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | CEREBELLUM |
| Key Genes/Proteins | ABI3, ADAM10, ALPHA-SYNUCLEIN, AMPK, AMYLOID |
| Related Diseases | AGING, ALS, ALZHEIMER'S DISEASE |
| Related Pathways | Ampk Signaling, AMPK SIGNALING |
Knowledge base pages for this entity
graph TD
CEREBELLUM["CEREBELLUM"]
CEREBELLUM -->|"interacts"| Purkinje_Cell["Purkinje Cell"]
CEREBELLUM -->|"expressed in"| PURKINJE["PURKINJE"]
CEREBELLUM -->|"causes"| TUMOR["TUMOR"]
Purkinje_Cell -->|"inhibits"| CEREBELLUM
ATP["ATP"] -->|"expressed in"| CEREBELLUM
DRP1["DRP1"] -->|"expressed in"| CEREBELLUM
PRKAA1["PRKAA1"] -->|"expressed in"| CEREBELLUM
JUN["JUN"] -->|"expressed in"| CEREBELLUM
NRF1["NRF1"] -->|"expressed in"| CEREBELLUM
OPA1["OPA1"] -->|"expressed in"| CEREBELLUM| Target | Relation | Type | Str |
|---|---|---|---|
| NEURON | expressed_in | cell_type | 0.95 |
| PURKINJE CELLS | expressed_in | cell_type | 0.80 |
| CORTEX | expressed_in | brain_region | 0.80 |
| Purkinje Cell | associated_with | entity | 0.70 |
| Purkinje Cell | interacts_with | entity | 0.70 |
| HIPPOCAMPUS | expressed_in | brain_region | 0.65 |
| SPINAL CORD | accumulates_in | brain_region | 0.65 |
| CORTEX | accumulates_in | brain_region | 0.65 |
| SUPEROXIDE | causes | phenotype | 0.65 |
| NEURON | contributes_to | cell_type | 0.65 |
| NEURONS | contributes_to | cell_type | 0.65 |
| PURKINJE | causes | cell_type | 0.60 |
| TUMOR | causes | disease | 0.60 |
| PURKINJE | expressed_in | cell_type | 0.60 |
| FTD | contributes_to | disease | 0.60 |
| STING | expressed_in | gene | 0.60 |
| PURKINJE | activates | cell_type | 0.60 |
| GABAERGIC | promotes | cell_type | 0.60 |
| PINK1 | expressed_in | gene | 0.60 |
| AGING | implicated_in | phenotype | 0.55 |
| C9orf72 | participates_in | gene | 0.55 |
| C9orf72 | implicated_in | gene | 0.55 |
| PLCG2 | expressed_in | gene | 0.55 |
| CORTEX | inhibits | brain_region | 0.50 |
| HIPPOCAMPUS | activates | brain_region | 0.50 |
| PSP | co_discussed | entity | 0.50 |
| FGFR1 | associated_with | gene | 0.50 |
| DEPRESSION | co_discussed | entity | 0.50 |
| MAPT | co_discussed | entity | 0.50 |
| TAU | co_discussed | entity | 0.50 |
| CORTEX | regulates | brain_region | 0.50 |
| AMYGDALA | activates | concept | 0.50 |
| SGMS1 | expressed_in | concept | 0.50 |
| FRONTAL | associated_with | concept | 0.50 |
| ENTORHINAL CORTEX | associated_with | concept | 0.50 |
| FCGRT | associated_with | concept | 0.50 |
| SYNCRIP | expressed_in | concept | 0.50 |
| PREFRONTAL CORTEX | associated_with | concept | 0.50 |
| HYPOTHALAMUS | co_discussed | entity | 0.50 |
| SCHIZOPHRENIA | co_discussed | entity | 0.50 |
| PINK1 | co_discussed | entity | 0.50 |
| INTERNEURON | co_discussed | entity | 0.50 |
| INTERNEURONS | co_discussed | entity | 0.50 |
| TREM2 | co_discussed | entity | 0.50 |
| TDP-43 | co_discussed | entity | 0.50 |
| LC3 | co_discussed | entity | 0.50 |
| TREM2 | associated_with | gene | 0.50 |
| VEGF | associated_with | gene | 0.50 |
| CHOLESTEROL | co_discussed | entity | 0.50 |
| STING | co_discussed | entity | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| neurodegeneration | affects | disease | 0.90 |
| ALS | affects | disease | 0.90 |
| ALS | associated_with | disease | 0.90 |
| Parkinson's disease | affects | disease | 0.90 |
| Huntington's disease | affects | disease | 0.90 |
| THAP11 | expressed_in | protein | 0.88 |
| PARKINSON'S DISEASE | associated_with | disease | 0.82 |
| LRP-1 | expressed_in | gene | 0.80 |
| CACNA1G | expressed_in | gene | 0.80 |
| frontotemporal dementia | affects | disease | 0.80 |
| RNA | expressed_in | gene | 0.80 |
| ALS | expressed_in | gene | 0.80 |
| C9orf72 Repeat Expansion | expressed_in | mechanism | 0.80 |
| spinal muscular atrophy | affects | disease | 0.80 |
| Alzheimer's disease | affects | disease | 0.80 |
| ALZHEIMER'S DISEASE | associated_with | disease | 0.72 |
| DNA | expressed_in | gene | 0.70 |
| CHOLESTEROL | produces | phenotype | 0.70 |
| CHOLESTEROL | destabilizes | phenotype | 0.70 |
| neuroinflammation | affects | disease | 0.70 |
| SQSTM1 | expressed_in | gene | 0.70 |
| Purkinje Cell | expressed_in | entity | 0.70 |
| Purkinje Cell | interacts_with | entity | 0.70 |
| schizophrenia | affects | disease | 0.70 |
| TFEB | expressed_in | gene | 0.70 |
| GFAP | expressed_in | gene | 0.70 |
| Purkinje Cell | activates | entity | 0.70 |
| Purkinje Cell | associated_with | entity | 0.70 |
| Purkinje Cell | inhibits | entity | 0.70 |
| BECN1 | expressed_in | gene | 0.70 |
| TARDBP | associated_with | gene | 0.66 |
| ATAXIA | reduces | disease | 0.65 |
| MAPT | encodes | gene | 0.65 |
| SCHIZOPHRENIA | interacts_with | disease | 0.65 |
| OLIGODENDROCYTES | protects_against | cell_type | 0.65 |
| ubiquitin-proteasome | active_in | pathway | 0.60 |
| synaptic plasticity | active_in | pathway | 0.60 |
| EFTUD2 | expressed_in | gene | 0.60 |
| STAU1 | expressed_in | gene | 0.60 |
| PAP | expressed_in | gene | 0.60 |
| FTLD | expressed_in | gene | 0.60 |
| ROS | expressed_in | gene | 0.60 |
| AMPK | expressed_in | gene | 0.60 |
| unfolded protein response | active_in | pathway | 0.60 |
| GFP | expressed_in | gene | 0.60 |
| LC3B | expressed_in | gene | 0.60 |
| GLUT4 | expressed_in | gene | 0.60 |
| ATG | expressed_in | gene | 0.60 |
| CYP46A1 | expressed_in | gene | 0.60 |
| MLCK | expressed_in | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Hippocampus ages transcriptionally faster than cerebellum, d | 0.516 | Alzheimer's disease | Allen Mouse Brain Aging Atlas: cross-age |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity