concept

MACROPHAGE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MACROPHAGE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2673Connections

7Hypotheses

0Analyses

50Outgoing

50Incoming

1Experiments

0Debates

Summary

MACROPHAGE is a concept in neurodegeneration research. Key relationships include: co discussed, activates, regulates. Associated with ALZHEIMER, ALZHEIMER'S, ALZHEIMER'S DISEASE. Connected to 293 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	MACROPHAGE
Key Genes/Proteins	ABCA1, ABCA7, ACHE, AD, AIF1, AKT
Related Diseases	ALZHEIMER, ALZHEIMER'S, ALZHEIMER'S DISEASE, AMYOTROPHIC LATERAL SCLEROSIS

Pathway Diagram

graph TD
    MACROPHAGE["MACROPHAGE"]
    MACROPHAGE -->|"activates"| glioblastoma["glioblastoma"]
    MACROPHAGE -->|"regulates"| INFLAMMATORY_RESPONSE["INFLAMMATORY_RESPONSE"]
    SQSTM1["SQSTM1"] -->|"expressed in"| MACROPHAGE
    BECN1["BECN1"] -->|"expressed in"| MACROPHAGE
    autophagy["autophagy"] -->|"regulates"| MACROPHAGE
    LOX["LOX"] -->|"activates"| MACROPHAGE
    P2RY12["P2RY12"] -->|"expressed in"| MACROPHAGE
    TMEM119["TMEM119"] -->|"expressed in"| MACROPHAGE
    GAIN["GAIN"] -->|"expressed in"| MACROPHAGE
    MICROGLIA["MICROGLIA"] -->|"expressed in"| MACROPHAGE

Outgoing (635)

Target	Relation	Type	Str
Axonal Loss	contributes_to	process	0.95
Cardiovascular Disease	involved_in	disease	0.95
Inflammatory Response	mediates	process	0.92
efferocytosis	involved_in	process	0.92
Multiple Sclerosis	contributes_to	disease	0.90
ConA-Induced Hepatitis	involved_in	disease	0.90
Atherosclerosis	associated_with	disease	0.90
IRON METABOLISM	involved_in	entity	0.90
Apoptotic Cell Clearance	mediates	process	0.90
Intracerebral Hemorrhage	involved_in	disease	0.90
ATHEROSCLEROSIS	contributes_to	entity	0.90
Inflammatory Pain Resolution	promotes	phenotype	0.90
Myocardial Fibrosis	involved_in	phenotype	0.88
cardiomyocyte hypertrophy	promotes	phenotype	0.87
Aneurysm	associated_with	disease	0.85
Coronary Heart Disease	associated_with	disease	0.85
Myocarditis	associated_with	disease	0.85
Peripheral Nerve Injury	involved_in	disease	0.85
neutrophil	associated_with	cell_type	0.85
Myocardial Infarction	involved_in	disease	0.85
Nerve Tissue Repair	involved_in	process	0.85
NLRP3 INFLAMMASOME	expressed_in	protein	0.85
Nerve Degeneration	mediates	process	0.85
P2RY12	expressed_in	entity	0.85
Immune Response	involved_in	process	0.85
TREM2	expressed_in	entity	0.85
INFLAMMATION	mediates	entity	0.85
Heart Failure	associated_with	disease	0.85
tubulointerstitial injury	associated_with	phenotype	0.80
NLRP3	markers	gene	0.70
TRAF6	markers	gene	0.70
RAGE	targets	gene	0.70
TREM2	mediates	gene	0.70
RIPK1	expresses	gene	0.70
PDGF	enhances	gene	0.70
RAGE	activates	gene	0.70
OLIGODENDROCYTES	expresses	cell_type	0.70
PERICYTES	activates	cell_type	0.70
OLIGODENDROCYTES	activates	cell_type	0.70
PI3K/AKT/MTOR	activates	pathway	0.70
WNT	regulates	gene	0.70
NFKB	activates	gene	0.70
PDGF	activates	gene	0.70
PERICYTE	activates	cell_type	0.70
P2RY12	stabilizes	gene	0.70
OLIGODENDROCYTE	expresses	cell_type	0.70
STING	targets	gene	0.70
TREM2	disrupts	gene	0.70
NOTCH	regulates	gene	0.70
STAT3	markers	gene	0.70

Incoming (2038)

Source	Relation	Type	Str
PARKINSON'S DISEASE	associated_with	disease	1.00
ALZHEIMER'S DISEASE	associated_with	disease	1.00
MICROGLIA	associated_with	cell_type	1.00
NF-KB	associated_with	protein	1.00
IFN-γ	activates	entity	0.90
PAD4	regulates	gene	0.90
CHRNA7	expressed_on	gene	0.90
MICROGLIA	activates	cell_type	0.90
ANXA1	modulates	protein	0.90
Piezo1	modulates	gene	0.90
Glycolytic Reprogramming	expressed_in	process	0.90
MIR-369-3P	expressed_in	gene	0.90
TET1	regulates	gene	0.90
HK2	expressed_in	entity	0.90
MKRN2	expressed_in	protein	0.85
CNS NICHE	modulates	entity	0.85
Proinflammatory Genetic Profile	associated_with	phenotype	0.85
APOE	regulates	gene	0.85
AKT	activates	gene	0.82
IL-6	associated_with	gene	0.82
MTOR	activates	gene	0.82
PCTR1	expressed_in	compound	0.80
Decursin	inhibits	drug	0.80
Annexin A1	regulates	protein	0.80
PAD4	associated_with	gene	0.80
TENASCINC	associated_with	protein	0.80
IL10	regulates	entity	0.80
HIF1A	expressed_in	gene	0.80
SIRT6	regulates	gene	0.80
Epsins	regulates	gene	0.80
IL13	activates	gene	0.80
RAB7A	expressed_in	protein	0.75
UBIQUITIN	associated_with	protein	0.74
MICROGLIA	regulates	cell_type	0.74
CSF1R	expresses	gene	0.70
GFAP	activates	gene	0.70
IBA1	activates	gene	0.70
APP	activates	gene	0.70
GRN	regulates	gene	0.70
ENDOTHELIAL	activates	cell_type	0.70
JAK	activates	gene	0.70
CX3CR1	targets	gene	0.70
GRN	causes	gene	0.70
CGAS	interacts_with	gene	0.70
CX3CL1	disrupts	gene	0.70
CX3CR1	disrupts	gene	0.70
CX3CR1	expresses	gene	0.70
CX3CL1	targets	gene	0.70
FTD	regulates	disease	0.70
CR1	activates	gene	0.70

Targeting Hypotheses (7)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Mutant-dependent amplification is context-dependent and stro	0.740	neurodegeneration	Do pathogenic LRRK2 mutations amplify vo
Peripheral Monocyte/Macrophage Infiltration Mimicking Microg	0.693	neuroinflammation	What causes IBA1 low/negative microglia
IL-10-Producing B10 Cells Establish AQP4-Specific Peripheral	0.648	neuroinflammation	How do B cells mechanistically orchestra
C1Q-Triggered NLRP3 Inflammasome Assembly in Plaque Macropha	0.640	neuroinflammation	What are the specific molecular mechanis
MOG-IgG induces spinal cord demyelination through Fcγ recept	0.560	neuroinflammation	What are the specific pathophysiological

CD36 Acts as Primary Aβ Oligomer Sensor on Perivascular Macr	0.535	neurodegeneration	How do perivascular cells specifically r
TREM2 on Perivascular Macrophages Senses Aβ and Drives SPP1	0.496	neurodegeneration	How do perivascular cells specifically r

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
IL-10 deficiency and VLC ceramide accumulation in inflammatory bowel d	validation	inflammatory bowel disease	0.900	0.00	IL-10 knockout mice	proposed	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MACROPHAGE in their description or question text

CD36 Acts as Primary Aβ Oligomer Sensor on Perivascular Macrophages, Triggering

Score: 0.535 · neurodegeneration · 2026-04-22

## Mechanistic Overview CD36 Acts as Primary Aβ Oligomer Sensor on Perivascular Macrophages, Triggering NF-κB-Dependent

TREM2 on Perivascular Macrophages Senses Aβ and Drives SPP1 Upregulation Through

Score: 0.496 · neurodegeneration · 2026-04-22

## Mechanistic Overview TREM2 on Perivascular Macrophages Senses Aβ and Drives SPP1 Upregulation Through CSF1R-Mediated