concept

CALCIUM SIGNALING

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CALCIUM SIGNALING: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

610Connections

2Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	CALCIUM SIGNALING
Key Genes/Proteins	ADAM10, AMYLOID, AMYLOID-BETA, APOE, AQP4, BDNF
Related Diseases	AGING, ALZHEIMER, ALZHEIMER'S DISEASE

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Calcium Signaling Pathway in Neurodegeneration

mechanism · 3338 words

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Pathway Diagram

graph TD
    CALCIUM_SIGNALING["CALCIUM SIGNALING"]
    CALCIUM_SIGNALING -->|"interacts"| Phagocytosis["Phagocytosis"]
    CALCIUM_SIGNALING -->|"interacts"| Apoptosis["Apoptosis"]
    CALCIUM_SIGNALING -->|"interacts"| Akt["Akt"]
    CALCIUM_SIGNALING -->|"interacts"| Pi3K["Pi3K"]
    CALCIUM_SIGNALING -->|"interacts"| Blood_Brain_Barrier["Blood-Brain Barrier"]
    BCL2["BCL2"] -->|"regulates"| CALCIUM_SIGNALING
    JUN["JUN"] -->|"regulates"| CALCIUM_SIGNALING
    MCOLN1["MCOLN1"] -->|"regulates"| CALCIUM_SIGNALING
    BANG["BANG"] -->|"activates"| CALCIUM_SIGNALING
    GPR37["GPR37"] -->|"activates"| CALCIUM_SIGNALING
    GENES["GENES"] -->|"regulates"| CALCIUM_SIGNALING
    Neurodegeneration["Neurodegeneration"] -->|"regulates"| CALCIUM_SIGNALING
    Als["Als"] -->|"regulates"| CALCIUM_SIGNALING
    Ms["Ms"] -->|"regulates"| CALCIUM_SIGNALING
    Inflammation["Inflammation"] -->|"activates"| CALCIUM_SIGNALING

Outgoing (118)

Target	Relation	Type	Str
ds-db4a006ea647	provides_data_for	dataset	1.00
Neuroregeneration	regulates	process	0.90
Macrophage Phagocytosis	mediates	process	0.90
Neuronal Cell Death	mediates	process	0.85
mitochondrial function	regulates	process	0.85
Neuronal Dendrites	involved_in	cell_type	0.80
neurons	active_in	cell_type	0.80
astrocytes	active_in	cell_type	0.70
synaptic plasticity	crosstalk_with	pathway	0.70
neural stem cells	active_in	cell_type	0.70
NEURODEGENERATION	treats	phenotype	0.65
CDK5	regulates	gene	0.65
INFLAMMATION	causes	phenotype	0.65
pericytes	active_in	cell_type	0.60
hippocampus	active_in	brain_region	0.60
oligodendrocytes	active_in	cell_type	0.60
cortex	active_in	brain_region	0.60
unfolded protein response	crosstalk_with	pathway	0.60
blood-brain barrier	active_in	brain_region	0.60
microglia	active_in	cell_type	0.60
Blood-Brain Barrier	interacts_with	pathway	0.55
Akt	interacts_with	pathway	0.55
Apoptosis	interacts_with	pathway	0.55
Phagocytosis	interacts_with	pathway	0.55
Pi3K	interacts_with	pathway	0.55
VEGF	co_discussed	entity	0.50
ENDOTHELIAL	co_discussed	entity	0.50
STING	co_discussed	entity	0.50
COMPLEMENT	co_discussed	entity	0.50
NMDA	co_discussed	entity	0.50
TNF	co_discussed	entity	0.50
NEURODEGENERATION	co_discussed	entity	0.50
CDK5	co_discussed	entity	0.50
CIRCADIAN	co_discussed	entity	0.50
IL6	co_discussed	entity	0.50
CORTEX	co_discussed	entity	0.50
PSEN1	co_discussed	entity	0.50
MITOCHONDRIA	co_discussed	entity	0.50
disease	associated_with	disease	0.50
PARKINSON'S	associated_with	concept	0.50
CYTOKINE	co_discussed	entity	0.50
PHAGOCYTOSIS	co_discussed	entity	0.50
SYNAPSE	co_discussed	entity	0.50
MICROGLIA	co_discussed	entity	0.50
DOPAMINERGIC	co_discussed	entity	0.50
PROTEOSTASIS	co_discussed	entity	0.50
LONG-TERM POTENTIATION	co_discussed	entity	0.50
Neuron	associated_with	cell_type	0.50
CREB	co_discussed	entity	0.50
OXIDATIVE STRESS	co_discussed	entity	0.50

Incoming (492)

Source	Relation	Type	Str
ds-db4a006ea647	data_in	dataset	1.00
Er-Plasma Membrane Junctions	mediates	mechanism	0.90
MERCS	regulates	process	0.90
ANNEXINS	involved_in	protein	0.90
ER-Mitochondria Contact Sites	involved_in	mechanism	0.90
APOE	inhibits	gene	0.90
ER-mitochondria distance	modulates	mechanism	0.90
MAMs	mediates	process	0.90
GRIN1	mediates	gene	0.90
P2 RECEPTORS	regulates	receptor	0.85
ER-Plasma Membrane Junctions	mediates	mechanism	0.85
APOE	associated_with	gene	0.85
PKC	participates_in	gene	0.85
Voltage-Gated Calcium Channels	regulates	protein	0.80
Alzheimer's disease	involves	disease	0.80
NEUROGRANIN	activates	protein	0.80
neuroinflammation	involves	disease	0.80
Als	regulates	disease	0.80
Alzheimer	therapeutic_target	disease	0.80
APOPTOSIS	therapeutic_target	gene	0.80
GLUCOCORTICOID RECEPTOR	regulates	receptor	0.75
AQP4	involved_in	protein	0.75
Rizzuto R	involved_in	protein	0.75
neurons	active_in	cell_type	0.75
AUTOPHAGY	activates	gene	0.70
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.70
ALZHEIMER	therapeutic_target	gene	0.70
Als	therapeutic_target	disease	0.70
INFLAMMATION	regulates	gene	0.70
MITOPHAGY	regulates	gene	0.70
Neurodegeneration	regulates	disease	0.70
BCL2	regulates	protein	0.70
Huntington's disease	involves	disease	0.70
NEURODEGENERATION	regulates	gene	0.70
synaptic plasticity	mediates	pathway	0.70
Inflammation	regulates	disease	0.65
LIPID PEROXIDATION	protects_against	phenotype	0.65
OXIDATIVE STRESS	regulates	phenotype	0.65
NEURONS	regulates	cell_type	0.65
VEGFA	regulates	gene	0.65
CREB	participates_in	gene	0.65
CASP3	regulates	gene	0.65
TRKB	activates	gene	0.60
BDNF	activates	gene	0.60
ALZHEIMER	associated_with	gene	0.60
ANXIETY	activates	gene	0.60
AMYLOID	activates	gene	0.60
MIRO1	regulates	gene	0.60
TAU	regulates	gene	0.60
RNA	regulates	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Layer V excitatory neurons show selectively enhanced vulnera	0.632	Alzheimer's disease	SEA-AD Single-Cell Analysis: Cell-Type V
Closed-loop transcranial focused ultrasound to restore hippo	0.551	Alzheimer's disease	Circuit-level neural dynamics in neurode

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (1)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Social Processing in the Amygdala: Single-Nucleus RNA-Sequencing Reveals Distinc [PMID:41727617]	Dwortz MF, Hofmann HA, Curley JP	Res Sq	2026	0

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CALCIUM SIGNALING in their description or question text

No additional research found