gene

NFKBIE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NFKBIE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

15Connections

0Hypotheses

0Analyses

7Outgoing

8Incoming

0Experiments

0Debates

Summary

NFKBIE encodes IκBε, a neuron-enriched NF-κB inhibitor isoform. Variants and expression changes modulate NF-κB activity in Alzheimer's, Parkinson's, and other neurodegenerative diseases.

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🧬 Gene Info

Gene Symbol	NFKBIE
Full Name	NFKB Inhibitor Epsilon
Chromosome	2p13.2
Function	modulate NF-κB activity in Alzheimer's
Primary Expression	Ubiquitous
Amino Acids	399 aa
Pathways	NFKB, nfkb, NF-κB, NF-κB signaling
UniProt ID	O00221
NCBI Gene ID	4794
GeneCards	NFKBIE
Human Protein Atlas	NFKBIE
Associated Diseases	neurodegeneration
Interactions	CDKN2A, KMT2D, NOTCH2, NSD2, SMARCA4, TP53
KG Connections	15 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: NFKBIE — AlphaFold O00221 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

NFKBIE Gene

gene · 663 words

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Pathway Diagram

graph TD
    NFKBIE["NFKBIE"]
    Aging{"Aging"}
    NFKBIE -->|"therapeutic_target"| Aging
    Als{"Als"}
    NFKBIE -->|"therapeutic_target"| Als
    Lymphoma{"Lymphoma"}
    NFKBIE -->|"therapeutic_target"| Lymphoma
    CDKN2A["CDKN2A"]
    NFKBIE -->|"interacts_with"| CDKN2A
    SMARCA4["SMARCA4"]
    NFKBIE -->|"interacts_with"| SMARCA4
    Epigenetic(["Epigenetic"])
    NFKBIE -->|"therapeutic_target"| Epigenetic
    Notch(["Notch"])
    NFKBIE -->|"interacts_with"| Notch
    CD19["CD19"]
    CD19 -->|"therapeutic_target"| NFKBIE
    TP53["TP53"]
    TP53 -->|"interacts_with"| NFKBIE
    SOX11["SOX11"]
    SOX11 -->|"therapeutic_target"| NFKBIE
    MYC["MYC"]
    MYC -->|"therapeutic_target"| NFKBIE
    AND["AND"]
    AND -->|"interacts_with"| NFKBIE
    KMT2D["KMT2D"]
    KMT2D -->|"interacts_with"| NFKBIE
    NSD2["NSD2"]
    NSD2 -->|"interacts_with"| NFKBIE
    NOTCH2["NOTCH2"]
    NOTCH2 -->|"interacts_with"| NFKBIE

Outgoing (7)

Target	Relation	Type	Str
Aging	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Lymphoma	therapeutic_target	disease	0.65
Epigenetic	therapeutic_target	pathway	0.60
Notch	interacts_with	pathway	0.60
CDKN2A	interacts_with	gene	0.60
SMARCA4	interacts_with	gene	0.60

Incoming (8)

Source	Relation	Type	Str
CYCLIN D1	therapeutic_target	gene	0.60
CD19	therapeutic_target	gene	0.60
TP53	interacts_with	gene	0.60
SOX11	therapeutic_target	gene	0.60
MYC	therapeutic_target	gene	0.60
KMT2D	interacts_with	gene	0.60
NSD2	interacts_with	gene	0.60
NOTCH2	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NFKBIE in their description or question text

No additional research found