gene

NSD2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NSD2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

34Connections

0Hypotheses

0Analyses

26Outgoing

8Incoming

0Experiments

0Debates

Summary

Page for NSD2 (Nuclear Receptor Binding SET Domain Protein 2)

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🧬 Gene Info

Gene Symbol	NSD2
Full Name	Nuclear Receptor Binding SET Domain Protein 2
Chromosome	4p16.3
Protein Type	Transferase
Function	encodes a histone lysine methyltransferase of the NSD family that catalyzes dimethylation of histone H3 at lysine 36 (H3K36me2).
Amino Acids	1365 aa
Pathways	Cholesterol
UniProt ID	[O96028](https://www.uniprot.org/uniprot/O96028)
Ensembl ID	ENSG00000109685
GeneCards	NSD2
Human Protein Atlas	NSD2
SET domain	The catalytic methyltransferase domain that specifically dimethylates H3K36
PWWP domain	Reads existing H3K36 methylation marks, enabling processive methylation along gene bodies
PHD fingers (4x)	Recognize various histone tail modifications for chromatin context-dependent activity
HMG box	Provides non-sequence-specific DNA binding capability
Associated Diseases	Als, Hepatitis, Lymphoma
Interactions	AND, CDKN2A, DNA, ERN1, KMT2D, MYC
KG Connections	34 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

NSD2 (Nuclear Receptor Binding SET Domain Protein 2)

gene · 1073 words

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Pathway Diagram

graph TD
    NSD2["NSD2"]
    Hepatitis{"Hepatitis"}
    NSD2 -->|"associated with"| Hepatitis
    Lymphoma{"Lymphoma"}
    NSD2 -->|"associated with"| Lymphoma
    Als{"Als"}
    NSD2 -->|"associated with"| Als
    Cholesterol(["Cholesterol"])
    NSD2 -->|"activates"| Cholesterol
    Histone_Modification(["Histone Modification"])
    NSD2 -->|"associated with"| Histone_Modification
    TP53["TP53"]
    NSD2 -->|"associated with"| TP53
    MYC["MYC"]
    NSD2 -->|"inhibits"| MYC
    NF__B["NF-KappaB"]
    NSD2 -->|"associated with"| NF__B
    NOTCH1["NOTCH1"]
    NSD2 -->|"inhibits"| NOTCH1
    ATM["ATM"]
    NSD2 -->|"associated with"| ATM
    Nf__b(["Nf-Kappab"])
    NSD2 -->|"associated with"| Nf__b
    Notch(["Notch"])
    NSD2 -->|"inhibits"| Notch
    ERN1["ERN1"]
    ERN1 -->|"activates"| NSD2
    style NSD2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (26)

Target	Relation	Type	Str
NF-κB	inhibits	pathway	0.80
p65	binds	transcription_factor	0.80
pancreatic tumorigenesis	inhibits	disease	0.80
Hepatitis	associated_with	disease	0.65
Aging	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Lymphoma	therapeutic_target	disease	0.65
Lymphoma	associated_with	disease	0.65
Als	associated_with	disease	0.65
NF-ΚB	associated_with	gene	0.60
Nf-Κb	associated_with	pathway	0.60
Notch	inhibits	pathway	0.60
NF-kB signaling	participates_in	pathway	0.60
NOTCH2	interacts_with	gene	0.60
NFKBIE	interacts_with	gene	0.60
CDKN2A	interacts_with	gene	0.60
CYCLIN D1	therapeutic_target	gene	0.60
SMARCA4	interacts_with	gene	0.60
Epigenetic	therapeutic_target	pathway	0.60
Notch	interacts_with	pathway	0.60
Cholesterol	activates	pathway	0.60
Histone Modification	associated_with	pathway	0.60
TP53	associated_with	gene	0.60
MYC	inhibits	gene	0.60
NOTCH1	inhibits	gene	0.60
ATM	associated_with	gene	0.60

Incoming (8)

Source	Relation	Type	Str
DNA	interacts_with	gene	0.60
ERN1	activates	gene	0.60
CD19	therapeutic_target	gene	0.60
TP53	interacts_with	gene	0.60
SOX11	therapeutic_target	gene	0.60
MYC	therapeutic_target	gene	0.60
KMT2D	interacts_with	gene	0.60
AND	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NSD2 in their description or question text

No additional research found