gene

CD19

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CD19: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

182Connections

0Hypotheses

0Analyses

50Outgoing

42Incoming

0Experiments

0Debates

Summary

CD19 is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, regulates, interacts with. Associated with ALS, Aging, Als. Connected to 115 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	CD19
Full Name	CD19 Molecule
Chromosome	16p11.2
Function	is a member of the immunoglobulin superfamily and functions as a critical signaling co-receptor on the surface of B cells.
Pathways	PI3K, PI3K Pathway, NF-κB
UniProt ID	P15391
NCBI Gene ID	933
Ensembl ID	ENSG00000177455
OMIM	107741
GeneCards	CD19
Human Protein Atlas	CD19
PI3K Pathway Activation	CD19 recruits PI3K p85 subunit, leading to Akt activation and metabolic reprogramming
Calcium Signaling	Facilitates PLCγ2 activation and intracellular calcium release
Survival Signaling	Promotes B-cell survival through NF-κB activation
Antibody Production	Critical for T-dependent antibody responses and germinal center formation
Associated Diseases	ALS, Autoimmune, Cancer, Inflammation, Lymphoma, Multiple Sclerosis
Known Drugs/Compounds	Inebilizumab-Cdon
Interactions	ACTB, AND, AQP4, C5, CAT, CCL5
KG Connections	181 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CD19 — AlphaFold P15391 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CD19 Gene

gene · 937 words

→

Pathway Diagram

graph TD
    CD19["CD19"]
    CD19 -.biomarker for.-> MS["MS"]
    CD19 -->|"target for"| Multiple_Sclerosis["Multiple Sclerosis"]
    CD19 -->|"target for"| Inflammation["Inflammation"]
    CD19 -->|"target for"| Als["Als"]
    CD19 -->|"target for"| Neuroinflammation["Neuroinflammation"]
    CD19 -->|"target for"| Autoimmune["Autoimmune"]
    CD19 -->|"target for"| Ms["Ms"]
    CD19 -->|"target for"| Leukemia["Leukemia"]
    CD19 -->|"regulates"| Cancer["Cancer"]
    AQP4["AQP4"] -->|"inhibits"| CD19
    ATG3["ATG3"] -->|"regulates"| CD19
    IRF1["IRF1"] -->|"regulates"| CD19
    TNF["TNF"] -->|"regulates"| CD19
    STAT1["STAT1"] -->|"regulates"| CD19
    GENES["GENES"] -->|"regulates"| CD19
    RB1CC1["RB1CC1"] -->|"regulates"| CD19
    TNFR1["TNFR1"] -->|"regulates"| CD19
    CD4["CD4"] -->|"interacts"| CD19
    MAPK3["MAPK3"] -->|"interacts"| CD19

Outgoing (140)

Target	Relation	Type	Str
Als	therapeutic_target	disease	0.95
NEUROMYELITIS OPTICA SPECTRUM DISORDER	therapeutic_target	entity	0.90
macrophages	expressed_in	cell_type	0.80
CD8	associated_with	gene	0.80
CD4	associated_with	gene	0.80
Lymphoma	therapeutic_target	disease	0.75
Multiple Sclerosis	therapeutic_target	disease	0.75
T cells	expressed_in	cell_type	0.70
MS	biomarker_for	disease	0.70
B Cell Activation	regulates	process	0.70
Checkpoint Inhibitor	therapeutic_target	pathway	0.70
microglia	expressed_in	cell_type	0.70
Cancer	biomarker_for	disease	0.65
ALS	causes	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Neuroinflammation	therapeutic_target	disease	0.65
Autoimmune	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Leukemia	therapeutic_target	disease	0.65
Cancer	regulates	disease	0.65
Tumor	associated_with	disease	0.65
Lymphoma	associated_with	disease	0.65
Ms	regulates	disease	0.65
Autoimmune	associated_with	disease	0.65
Tumor	therapeutic_target	disease	0.65
Glioblastoma	therapeutic_target	disease	0.65
Autism	regulates	disease	0.65
Aging	therapeutic_target	disease	0.65
Neuroinflammation	causes	disease	0.65
Inflammation	causes	disease	0.65
Multiple Sclerosis	causes	disease	0.65
Autoimmune	causes	disease	0.65
Cancer	causes	disease	0.65
Infection	therapeutic_target	disease	0.65
Ms	expressed_in	disease	0.65
Tumor	expressed_in	disease	0.65
Cancer	therapeutic_target	disease	0.65
APOPTOSIS	therapeutic_target	gene	0.60
Apoptosis	therapeutic_target	pathway	0.60
Immune Checkpoint	therapeutic_target	pathway	0.60
AND	associated_with	gene	0.60
AND	inhibits	gene	0.60
Immune Response	therapeutic_target	pathway	0.60
CANCER	regulates	gene	0.60
APOPTOSIS	regulates	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
TNF-Α	regulates	gene	0.60
AUTOPHAGY-RELATED GENES	regulates	gene	0.60
CANCER	therapeutic_target	gene	0.60
cancer	regulates	disease	0.60

Incoming (42)

Source	Relation	Type	Str
Inebilizumab	targets	drug	0.90
Inebilizumab-Cdon	targets	drug	0.85
BCL2	therapeutic_target	gene	0.70
MYC	therapeutic_target	gene	0.70
ASTROCYTES	causes	gene	0.60
AQP4	inhibits	gene	0.60
CD4	interacts_with	gene	0.60
MAPK3	interacts_with	gene	0.60
ZAP70	interacts_with	gene	0.60
GENES	regulates	gene	0.60
AQP4	therapeutic_target	gene	0.60
FAS	regulates	gene	0.60
SF3B1	therapeutic_target	gene	0.60
CDK1	inhibits	gene	0.60
TP53	interacts_with	gene	0.60
COMPLEMENT	inhibits	gene	0.60
RNA	associated_with	gene	0.60
AND	associated_with	gene	0.60
CANCER	causes	gene	0.60
ATG3	regulates	gene	0.60
IRF1	regulates	gene	0.60
TNF	regulates	gene	0.60
STAT1	regulates	gene	0.60
RB1CC1	regulates	gene	0.60
TNFR1	regulates	gene	0.60
CD47	therapeutic_target	gene	0.60
GBM	therapeutic_target	gene	0.60
PHAGOCYTOSIS	therapeutic_target	gene	0.60
GLIOBLASTOMA	therapeutic_target	gene	0.60
ASTROCYTE	causes	gene	0.60
MIRNAS	regulates	gene	0.60
BECN1	regulates	gene	0.60
C5	inhibits	gene	0.60
NEUROINFLAMMATION	causes	gene	0.60
MICROGLIA	therapeutic_target	gene	0.60
APOPTOSIS	regulates	gene	0.60
AUTOPHAGY-RELATED GENES	regulates	gene	0.60
ASTROCYTE	therapeutic_target	gene	0.60
ASTROCYTES	therapeutic_target	gene	0.60
CANCER	co_discussed	gene	0.50
ATG3	co_expressed_with	gene	0.50
BECN1	co_expressed_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CD19 in their description or question text

No additional research found