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gene 1,049 words KG: SMARCA4
Contents

SMARCA4

🧬 Gene Info
Gene SymbolSMARCA4
Chromosome19p13.2
FunctionATP-dependent chromatin remodeling ATPase
Primary Expressionthe cerebral cortex, hippocampus, and cerebellum
Amino Acids1647 aa
Exons35
PathwaysEpigenetic
Ensembl IDENSG00000127616
GeneCardsSMARCA4
Human Protein AtlasSMARCA4
Associated DiseasesAD, ALI, Als, AMI, cancer
Known Drugs/Compoundsrapamycin
InteractionsAND, APOB, ARID1A, ASC, ATG, BECLIN1
SciDEX HypothesesChromatin Remodeling-Mediated Nutrient Sensing Res
KG Connections320 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (4)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73KDM6A-Mediated H3K27me3 Rejuvenation
Score: 0.65Grid Cell-Specific Metabolic Reprogramming via IDH2 Enhancem
Score: 0.65

Related Analyses (4)

Epigenetic reprogramming in aging neurons
neurodegeneration · completedSelective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archivedEpigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archivedCircuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (15)

AMPK (AMP-Activated Protein Kinase)
entity · KG edge: contributes_toAutophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: activatesABCB1 (MDR1) - ATP Binding Cassette Subfamily B Member
gene · KG edge: therapeutic_targetALDH1A1 Gene
gene · KG edge: therapeutic_targetAPC Gene
gene · KG edge: regulates

Knowledge Graph (12 edges)

IDH1 therapeutic_target SMARCA4
VEGFA therapeutic_target SMARCA4
MDM4 therapeutic_target SMARCA4
APOB therapeutic_target SMARCA4
SF3B1 associated_with SMARCA4
MET therapeutic_target SMARCA4
SMARCA4 therapeutic_target TERT
SMARCA4 therapeutic_target JUN
SMARCA4 associated_with EEF1A1
SMARCA4 therapeutic_target MCL1

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