gene

HNRNPA1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HNRNPA1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

427Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

Page for HNRNPA1 - Heterogeneous Nuclear Ribonucleoprotein A1

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🧬 Gene Info

Gene Symbol	HNRNPA1
Aliases	Page for HNRNPA1
Chromosome	12q13.13
Function	In neurons and other cell types, hnRNP A1 plays critical roles in multiple aspects of RNA metabolism and cellular stress response:
Primary Expression	Ubiquitous, high in brain and muscle
Subcellular Localization	</strong></td><td>Nucleus, cytoplasm, stress granules</td></tr>
Molecular Weight	38 kDa
Amino Acids	372 aa
Pathways	Alpha-Synuclein, Er Stress, Synaptic Plasticity
UniProt ID	P09651
NCBI Gene ID	3178
Ensembl ID	ENSG00000166086
OMIM	164017
GeneCards	HNRNPA1
Human Protein Atlas	HNRNPA1
Associated Diseases	Als, Amyotrophic Lateral Sclerosis, Anxiety, Cancer, Carcinoma, dementia
Known Drugs/Compounds	PACLITAXEL
Interactions	AGING, ALOX15, AMYOTROPHIC LATERAL SCLEROSIS, AND, App, APP
KG Connections	424 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: HNRNPA1 — AlphaFold P09651 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (5)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    HNRNPA1["HNRNPA1
RNA-binding protein"]
    
    ALS["ALS
Amyotrophic Lateral Sclerosis"]
    FTD["FTD
Frontotemporal Dementia"]
    MS["Multiple Sclerosis"]
    NEURO["Neurodegeneration"]
    
    VCP["VCP
Valosin-containing protein"]
    TIA1["TIA1
T-cell intracellular
antigen 1"]
    
    ALOX15["ALOX15
Arachidonate
15-lipoxygenase"]
    FERROPTOSIS["Ferroptosis
Iron-dependent
cell death"]
    LIPID_MET["Lipid Metabolism"]
    
    AUTOPHAGY["Autophagy
Cellular clearance"]
    IMMUNITY["Innate Immunity
Immune response"]
    
    USP7["USP7
Ubiquitin-specific
peptidase 7"]
    
    HNRNPA1 -->|"activates"| ALS
    HNRNPA1 -->|"associated_with"| FTD
    HNRNPA1 -->|"activates"| MS
    HNRNPA1 -->|"activates"| NEURO
    
    HNRNPA1 -->|"associated_with"| VCP
    HNRNPA1 -->|"associated_with"| TIA1
    
    HNRNPA1 -->|"inhibits"| ALOX15
    ALOX15 -->|"promotes"| FERROPTOSIS
    HNRNPA1 -->|"inhibits"| FERROPTOSIS
    HNRNPA1 -->|"inhibits"| LIPID_MET
    
    HNRNPA1 -->|"expressed_in"| AUTOPHAGY
    HNRNPA1 -->|"activates"| IMMUNITY
    
    HNRNPA1 -->|"inhibits"| USP7
    
    FERROPTOSIS -->|"contributes_to"| NEURO
    AUTOPHAGY -->|"dysregulated_in"| ALS
    VCP -->|"mutations_cause"| FTD
    
    style HNRNPA1 fill:#006494
    style ALS fill:#ef5350
    style FTD fill:#ef5350
    style MS fill:#ef5350
    style NEURO fill:#ef5350
    style VCP fill:#4a1a6b
    style TIA1 fill:#4a1a6b
    style ALOX15 fill:#4a1a6b
    style FERROPTOSIS fill:#ef5350
    style LIPID_MET fill:#1b5e20
    style AUTOPHAGY fill:#1b5e20
    style IMMUNITY fill:#5d4400
    style USP7 fill:#4a1a6b

Outgoing (286)

Target	Relation	Type	Str
PEDV N PROTEIN	degrades	protein	0.95
Pedv N Protein	degrades	protein	0.95
PEDV N protein	inhibits	protein	0.95
Pedv	inhibits	entity	0.90
Multisystem Proteinopathy	causes	disease	0.90
PEDV	protects_against	disease	0.90
PEDV infection	protects_against	disease	0.90
MARCHF8	activates	protein	0.85
RNA Stress Granule	involved_in	process	0.85
Mir-522	mediates	biomarker	0.85
Interferon	upregulates	protein	0.85
DDX58	interacts_with	protein	0.80
Interferon Production	upregulates	process	0.80
interferon response	promotes	process	0.80
MARCHF8	interacts_with	protein	0.80
Viral Replication	inhibits	process	0.80
Antiviral Defense Response	mediates	process	0.80
LC3	activates	entity	0.80
Viral Infection	inhibits	process	0.80
OPTN	interacts_with	entity	0.70
ALS	activates	disease	0.65
Cancer	associated_with	disease	0.65
Amyotrophic Lateral Sclerosis	biomarker_for	disease	0.65
Dementia	interacts_with	disease	0.65
Leukemia	regulates	disease	0.65
Carcinoma	associated_with	disease	0.65
Ms	interacts_with	disease	0.65
Tumor	associated_with	disease	0.65
Als	expressed_in	disease	0.65
Aging	regulates	disease	0.65
Ms	therapeutic_target	disease	0.65
Neurodegeneration	regulates	disease	0.65
Neurodegeneration	activates	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Ms	activates	disease	0.65
Als	regulates	disease	0.65
Spinal Muscular Atrophy	associated_with	disease	0.65
Cancer	inhibits	disease	0.65
Tumor	inhibits	disease	0.65
Als	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Dementia	associated_with	disease	0.65
Als	activates	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Tumor	activates	disease	0.65
Frontotemporal Dementia	associated_with	disease	0.65
Longevity	regulates	disease	0.65
Ms	regulates	disease	0.65
Amyotrophic Lateral Sclerosis	interacts_with	disease	0.65
Cancer	regulates	disease	0.65

Incoming (141)

Source	Relation	Type	Str
Pedv N Protein	degrades	protein	0.95
EGR1	upregulates	protein	0.90
PEDV N PROTEIN	interacts_with	protein	0.85
DDX58	interacts_with	protein	0.75
PACLITAXEL	activates	drug	0.65
SQSTM1	associated_with	gene	0.60
OPTN	associated_with	gene	0.60
YWHAZ	associated_with	gene	0.60
VDAC1	associated_with	gene	0.60
TDP43	implicated_in	gene	0.60
TAU	expressed_in	gene	0.60
FGF2	activates	gene	0.60
APP	inhibits	gene	0.60
ALOX15	activates	entity	0.60
ALOX15	associated_with	entity	0.60
UBIQUITIN	regulates	gene	0.60
OPTN	degrades	gene	0.60
SQSTM1	degrades	gene	0.60
TIA1	degrades	gene	0.60
HNRNPA2B1	degrades	gene	0.60
OPTINEURIN	degrades	gene	0.60
TAF15	activates	gene	0.60
ATXN2	associated_with	gene	0.60
STAT3	activates	gene	0.60
SOD1	biomarker_for	gene	0.60
TARDBP	regulates	gene	0.60
GAIN	associated_with	gene	0.60
TBC1D24	expressed_in	gene	0.60
PLIN4	expressed_in	gene	0.60
BID	expressed_in	gene	0.60
ANXIETY	associated_with	gene	0.60
FUS	associated_with	gene	0.60
HNRNPA2B1	associated_with	gene	0.60
TIA1	associated_with	gene	0.60
TNFRSF11A	activates	gene	0.60
TNFRSF11B	activates	gene	0.60
AUTOPHAGY	expressed_in	gene	0.60
ATG	degrades	gene	0.60
AND	expressed_in	gene	0.60
EXOSOMES	activates	gene	0.60
IL-6	activates	gene	0.60
RNA	activates	gene	0.60
RAF	activates	gene	0.60
MIRNAS	regulates	gene	0.60
GENES	regulates	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	biomarker_for	gene	0.60
AND	regulates	gene	0.60
PARK7	regulates	gene	0.60
PGC1ALPHA	regulates	gene	0.60
NURR1	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning HNRNPA1 in their description or question text

No additional research found

HNRNPA1

Understanding Entity Pages

Summary

Wiki Pages (5)

HNRNPA1 Protein

HNRNPA1 Protein

HNRNPA1 - Heterogeneous Nuclear Ribonucleoprotein A1

HNRNPA1 Gene

HNRNPA1 Protein

Pathway Diagram

Outgoing (286)

Incoming (141)

Targeting Hypotheses (0)

Mentioning Analyses (0)

Experiments (0)

Related Papers (0)

Debates (0)

Related Research