concept

SELECTIVE AUTOPHAGY

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SELECTIVE AUTOPHAGY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

173Connections

1Hypotheses

1Analyses

32Outgoing

50Incoming

0Experiments

1Debates

No summary available yet.

View on Wiki →

No AI portrait yet

💡 Concept Info

Name	SELECTIVE AUTOPHAGY
Key Genes/Proteins	amyotrophic lateral sclerosis, ANXA1, ATG5, BAG3, BCL2, BECN1
Related Diseases	cancer, disease
Related Pathways	Chaperone

Pathway Diagram

graph TD
    SELECTIVE_AUTOPHAGY["SELECTIVE AUTOPHAGY"]
    style SELECTIVE_AUTOPHAGY fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    SELECTIVE_AUTOPHAGY -->|"targets"| PEDV_N_protein([PEDV N protein])
    SELECTIVE_AUTOPHAGY -.->|"degrades"| PEDV_N([PEDV N])
    SELECTIVE_AUTOPHAGY -.->|"protects against"| Neurodegeneration["Neurodegeneration"]
    SELECTIVE_AUTOPHAGY -.->|"inhibits"| STAT2([STAT2])
    SELECTIVE_AUTOPHAGY -->|"component_of"| Mitophagy["Mitophagy"]
    SELECTIVE_AUTOPHAGY -->|"component_of"| Xenophagy["Xenophagy"]
    SELECTIVE_AUTOPHAGY -->|"component_of"| Aggrephagy["Aggrephagy"]
    SELECTIVE_AUTOPHAGY -->|"involved_in"| Cancer["Cancer"]
    SELECTIVE_AUTOPHAGY -->|"involved_in"| Mitochondria["/Mitochondria/"]
    SELECTIVE_AUTOPHAGY -->|"mediates"| Protein_Degradation["Protein Degradation"]
    ULK1([ULK1]) -->|"involved_in"| SELECTIVE_AUTOPHAGY
    SQSTM1([SQSTM1]) -->|"participates in"| SELECTIVE_AUTOPHAGY
    SQSTM1G427R([SQSTM1G427R]) -.->|"inhibits"| SELECTIVE_AUTOPHAGY
    TOLLIP([TOLLIP]) -->|"participates in"| SELECTIVE_AUTOPHAGY
    CALCOCO2([CALCOCO2]) -->|"participates in"| SELECTIVE_AUTOPHAGY
    Parkin([Parkin]) -->|"activates"| SELECTIVE_AUTOPHAGY
    PRKN([PRKN]) -->|"activates"| SELECTIVE_AUTOPHAGY
    NDP52([NDP52]) -->|"participates in"| SELECTIVE_AUTOPHAGY
    Ubiquitin_Phosphorylation["Ubiquitin Phosphorylation"] -->|"mediates"| SELECTIVE_AUTOPHAGY

Outgoing (32)

Target	Relation	Type	Str
Pedv N Protein	mediates	protein	0.95
Cancer	associated_with	disease	0.95
PEDV N	degrades	protein	0.95
neurodegeneration	protects_against	disease	0.95
PEDV N protein	targets	protein	0.95
Neurodegeneration	protects_against	disease	0.95
Aggrephagy	component_of	process	0.90
Xenophagy	component_of	process	0.90
Mitochondria	involved_in	cell_type	0.90
Aggressive Lymphomas	associated_with	disease	0.90
STAT2	inhibits	protein	0.90
Btk Inhibitors	associated_with	drug	0.90
Mitophagy	component_of	process	0.90
Neurodegenerative Diseases	involved_in	disease	0.85
Protein Degradation	mediates	process	0.85
Neurodegeneration	associated_with	disease	0.80
Infection	associated_with	disease	0.80
Autophagy Initiation	mediates	process	0.80
ubiquitination	promotes	process	0.80
Mitophagy	involved_in	process	0.80
senescence-associated secretory phenotype	regulates	phenotype	0.78
UBIQUITIN	upstream_of	protein	0.75
neurodegeneration	associated_with	disease	0.70
infection	associated_with	disease	0.70
neurological diseases	associated_with	disease	0.70
RAPAMYCIN	activates	concept	0.50
STEM CELLS	activates	concept	0.50
AUTOPHAGOSOME	interacts_with	concept	0.50
PEROXISOME	activates	concept	0.50
AUTOPHAGOSOME	associated_with	concept	0.50
ENDOPLASMIC RETICULUM	associated_with	concept	0.50
α-SYNUCLEIN	decreases_risk	concept	0.50

Incoming (141)

Source	Relation	Type	Str
SQSTM1	mediates	gene	0.95
ULK1	involved_in	protein	0.95
ATG5	involved_in	gene	0.90
MARCHF8	involved_in	enzyme	0.90
SQSTM1	participates_in	protein	0.90
SQSTM1G427R	inhibits	protein	0.90
Ubiquitin Phosphorylation	mediates	mechanism	0.90
SQSTM1	involved_in	protein	0.90
Mitochondria	substrate_of	organelle	0.90
PEDV N PROTEIN	modulates	protein	0.90
TOLLIP	participates_in	protein	0.90
CALCOCO2	participates_in	protein	0.90
Parkin	activates	gene	0.90
PRKN	activates	gene	0.90
NDP52	participates_in	protein	0.90
Small-Molecule Compounds	targets	compound	0.85
Molecular Markers	biomarker_for	biomarker	0.85
Parkin	associated_with	protein	0.85
OPTN	involved_in	protein	0.85
NDP52	involved_in	protein	0.85
TBK1	regulates	protein	0.85
ISG15	regulates	gene	0.85
Proteasomes	substrate_of	organelle	0.85
Endoplasmic Reticulum	substrate_of	organelle	0.85
P62	involved_in	protein	0.85
NBR1	involved_in	protein	0.85
Mitophagy	involved_in	process	0.80
OPTN	regulates	protein	0.70
SQSTM1	mediates	gene	0.70
p62	regulates	protein	0.70
NBR1	regulates	protein	0.70
NDP52	regulates	protein	0.70
TBK1	activates	protein	0.70
PINK1	regulates	protein	0.70
Parkin	regulates	protein	0.70
Neurodegenerative Diseases	activates	disease	0.50
NFE2L2	activates	gene	0.50
SQSTM1	regulates	gene	0.50
P62/SQSTM1	regulates	protein	0.50
HSP27	regulates	protein	0.50
SQSTM1	interacts_with	gene	0.50
NEURONS	interacts_with	concept	0.50
cancer	associated_with	disease	0.50
MITOCHONDRIA	associated_with	cell_type	0.50
Neurodegenerative Diseases	associated_with	disease	0.50
Heart Failure	associated_with	disease	0.50
TUMOR	associated_with	disease	0.50
MITOCHONDRIA	interacts_with	cell_type	0.50
cancer	interacts_with	disease	0.50
mitophagy	interacts_with	pathway	0.50

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Synaptic-Selective Autophagy Receptor Expression to Bypass A	0.416	proteomics	Quantitative proteomics of the aging syn

Mentioning Analyses (1)

Scientific analyses that reference this entity

How do non-cell autonomous effects of autophagy dysfunction contribute to ALS pa

neurodegeneration | 2026-04-08 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

How do non-cell autonomous effects of autophagy dysfunction contribute to ALS pa

closed · Rounds: 4 · Score: 0.94 · 2026-04-10

Related Research

Hypotheses and analyses mentioning SELECTIVE AUTOPHAGY in their description or question text

No additional research found