gene 1,008 words KG: MLKL
Contents

MLKL Gene

🧬 Gene Info
Gene SymbolMLKL
Chromosome16q23.1
Protein FamilyRHIM domain-containing pseudo-kinase
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight~54 kDa
Amino Acids480 aa
Exons10
PathwaysAkt, Apoptosis, Autophagy, Cell Division, Ferroptosis
UniProt IDQ8TBX5
NCBI Gene ID83568
Ensembl IDENSG00000147854
GeneCardsMLKL
Human Protein AtlasMLKL
Associated DiseasesAls, Alzheimer's disease, autism, DEMYELINATION, disease
Known Drugs/CompoundsHSYA, metformin, METFORMIN, Necrosulfonamide, rapamycin, RAPAMYCIN
InteractionsACSL4, Actin, AD, AIF, AIM2, AKT
KG Connections1241 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (10)

ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.89
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
CYP46A1 Overexpression Gene Therapy
Score: 0.77
Multi-Modal Stress Response Harmonization
Score: 0.76
Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.72
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.70
Microbial Inflammasome Priming Prevention
Score: 0.65
FOXO3-Longevity Pathway Epigenetic Reprogramming
Score: 0.63
Extracellular Vesicle Biogenesis Modulation
Score: 0.58

Related Analyses (7)

Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

Related Experiments (1)

Regulated Necrosis Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40

See Also (9)

AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
ACSL4 Gene - Acyl-CoA Synthetase Long Chain Family Memb
gene · KG edge: inhibits
AIF Gene
gene · KG edge: regulates
AKT1 Gene
gene · KG edge: interacts_with
ALOX15 - Arachidonate 15-Lipoxygenase
gene · KG edge: inhibits

Knowledge Graph (12 edges)

ATF6 interacts_with MLKL
OPTN interacts_with MLKL
CASP3 interacts_with MLKL
AKT1 interacts_with MLKL
CALCOCO2 interacts_with MLKL
CGAS interacts_with MLKL
CFTR interacts_with MLKL
SQSTM1 interacts_with MLKL
RPS6KB1 interacts_with MLKL
GRB2 interacts_with MLKL

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