gene

FADD

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FADD: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

159Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

FADD (Fas-Associated via Death Domain) - adaptor protein in extrinsic apoptosis and death receptor signaling, with emerging roles in neuroinflammation and neurodegeneration

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🧬 Gene Info

Gene Symbol	FADD
Aliases	Fas-Associated via Death Domain
Chromosome	11q13.3
Protein Type	Adaptor Protein
Function	is a critical adaptor protein that serves as a molecular bridge between death receptor activation and caspase-mediated apoptosis.
Molecular Weight	23 kDa
Amino Acids	208 aa
Pathways	signaling: [@supsup2014], NF-κB
UniProt ID	Q13131
NCBI Gene ID	3558
GeneCards	FADD
Human Protein Atlas	FADD
Associated Diseases	traumatic brain injury
Interactions	ABCG2, Actin, AND, APOPTOSIS, BAX, BCL-2
KG Connections	159 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: FADD — AlphaFold Q13131 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

FADD Gene

gene · 1802 words

→

FADD Protein

protein · 837 words

→

Pathway Diagram

flowchart TD
    FADD["FADD"] -->|"activates"| Inflammation["Inflammation"]
    FADD["FADD"] -->|"activates"| Ms["Ms"]
    FADD["FADD"] -->|"activates"| Als["Als"]
    FADD["FADD"] -->|"regulates"| Ms["Ms"]
    FADD["FADD"] -->|"interacts with"| Als["Als"]
    FADD["FADD"] -->|"interacts with"| Ms["Ms"]
    FADD["FADD"] -->|"interacts with"| Cancer["Cancer"]
    FADD["FADD"] -->|"therapeutic target"| Aging["Aging"]
    FADD["FADD"] -->|"therapeutic target"| Stroke["Stroke"]
    FADD["FADD"] -->|"activates"| NRF2["NRF2"]
    FADD["FADD"] -->|"activates"| ABCG2["ABCG2"]
    FADD["FADD"] -->|"activates"| ZBP1["ZBP1"]
    style FADD fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style Inflammation fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ms fill:#ef5350,stroke:#333,color:#e0e0e0
    style Als fill:#ef5350,stroke:#333,color:#e0e0e0
    style Cancer fill:#ef5350,stroke:#333,color:#e0e0e0
    style Aging fill:#ef5350,stroke:#333,color:#e0e0e0
    style Stroke fill:#ef5350,stroke:#333,color:#e0e0e0
    style NRF2 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style ABCG2 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style ZBP1 fill:#4a1a6b,stroke:#333,color:#e0e0e0

Outgoing (100)

Target	Relation	Type	Str
MLKL	activates	gene	0.70
Ms	regulates	disease	0.65
Als	activates	disease	0.65
Colorectal Cancer	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Tumor	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Tumor	activates	disease	0.65
Cancer	activates	disease	0.65
Tumor	regulates	disease	0.65
ALS	activates	disease	0.65
Als	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Cancer	interacts_with	disease	0.65
Aging	therapeutic_target	disease	0.65
Stroke	therapeutic_target	disease	0.65
Inflammation	inhibits	disease	0.65
Neurodegeneration	activates	disease	0.65
Ms	activates	disease	0.65
Inflammation	activates	disease	0.65
RIP1	activates	gene	0.60
RIP3	activates	gene	0.60
MAPK signaling	participates_in	pathway	0.60
BAX	activates	gene	0.60
Apoptosis	activates	pathway	0.60
Necroptosis	inhibits	pathway	0.60
Apoptosis	inhibits	pathway	0.60
neurons	expressed_in	cell_type	0.60
BCL-2	activates	gene	0.60
HO-1	activates	gene	0.60
Oxidative Stress	activates	pathway	0.60
pyroptosis	participates_in	pathway	0.60
apoptosis pathway	participates_in	pathway	0.60
RIP1	inhibits	gene	0.60
RIP3	inhibits	gene	0.60
NRF2	activates	gene	0.60
ABCG2	activates	gene	0.60
ZBP1	activates	gene	0.60
MFN2	activates	gene	0.60
GSDMD	activates	gene	0.60
RIPK1	activates	gene	0.60
RAB7A	activates	gene	0.60
CAT	activates	gene	0.60
TNF	regulates	gene	0.60
TNF	associated_with	gene	0.60
TNF	activates	gene	0.60
IL10	regulates	gene	0.60
MAPK1	regulates	gene	0.60
SREBF2	regulates	gene	0.60
Glycolysis	activates	pathway	0.60

Incoming (59)

Source	Relation	Type	Str
IFN	activates	gene	0.60
TNF-ALPHA	activates	gene	0.60
CASP8	interacts_with	gene	0.60
RIPK1	interacts_with	gene	0.60
MLKL	interacts_with	gene	0.60
RIPK3	activates	gene	0.60
STAT3	therapeutic_target	gene	0.60
CD163	therapeutic_target	gene	0.60
AKT	therapeutic_target	gene	0.60
CD68	therapeutic_target	gene	0.60
TRAF2	associated_with	gene	0.60
DNA	activates	gene	0.60
DRP1	activates	gene	0.60
CYTOKINES	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
MITOCHONDRIAL DYSFUNCTION	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
HO-1	activates	gene	0.60
GLUT1	activates	gene	0.60
ROS	regulates	gene	0.60
CANCER	activates	gene	0.60
TNF-Α	regulates	gene	0.60
NF-KB	activates	gene	0.60
MITOCHONDRIA	activates	gene	0.60
BAX	activates	gene	0.60
ANXA5	regulates	gene	0.60
AND	activates	gene	0.60
AND	regulates	gene	0.60
FAS	activates	gene	0.60
RIPK3	inhibits	gene	0.60
RIPK1	regulates	gene	0.60
ZBP1	regulates	gene	0.60
RIPK3	regulates	gene	0.60
NLRP3	regulates	gene	0.60
FAS	interacts_with	gene	0.60
CASP6	interacts_with	gene	0.60
DES	interacts_with	gene	0.60
FAS	associated_with	gene	0.60
MLKL	activates	gene	0.60
CANCER	interacts_with	gene	0.60
BCL-2	activates	gene	0.60
RAB7A	activates	gene	0.60
MFN2	activates	gene	0.60
GSDMD	activates	gene	0.60
CAT	activates	gene	0.60
ABCG2	activates	gene	0.60
RIPK1	activates	gene	0.60
ZBP1	activates	gene	0.60
TNFA	interacts_with	protein	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning FADD in their description or question text

No additional research found