gene

GASDERMIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GASDERMIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

682Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

No summary available yet.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	GSDM family
Full Name	Gasdermin family
Aliases	GSDMA, GSDMB, GSDMC, GSDMD, GSDME
Function	Pore-forming proteins executing pyroptosis. GSDMD is cleaved by inflammatory caspases to form membrane pores.
Primary Expression	Macrophages, monocytes, microglia, neurons
Gene Type	Protein-coding gene family
Pathways	Pyroptosis, Inflammasome signaling, NLRP3 pathway
Associated Diseases	Als, Alzheimer, Infection, Inflammation, Ms
Interactions	Actin, AD, AIM2, ALS, ALZHEIMER, ALZHEIMER'S DISEASE
KG Connections	680 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Pathway Diagram

graph TD
    GASDERMIN["GASDERMIN"] -.->|"inhibits"| Inflammation["Inflammation"]
    GASDERMIN["GASDERMIN"] -->|"activates"| Neuroinflammation["Neuroinflammation"]
    GASDERMIN["GASDERMIN"] -->|"associated"| Inflammation_1["Inflammation"]
    GASDERMIN["GASDERMIN"] -->|"activates"| Stroke["Stroke"]
    GASDERMIN["GASDERMIN"] -->|"activates"| Inflammation_2["Inflammation"]
    GASDERMIN["GASDERMIN"] -->|"associated"| Infection["Infection"]
    CANCER["CANCER"] -.->|"inhibits"| GASDERMIN["GASDERMIN"]
    CELL_DEATH["CELL DEATH"] -->|"activates"| GASDERMIN["GASDERMIN"]
    CELL_DEATH_3["CELL DEATH"] -->|"causes"| GASDERMIN["GASDERMIN"]
    APOPTOSIS["APOPTOSIS"] -->|"degrades"| GASDERMIN["GASDERMIN"]
    style GASDERMIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (426)

Target	Relation	Type	Str
Lysosome Permeabilization	mediates	process	0.90
NEURONS	expresses	cell_type	0.70
STING	activates	gene	0.70
TNF	activates	gene	0.70
NEURONS	activates	cell_type	0.70
NECROPTOSIS	mediates	pathway	0.70
RAGE	activates	gene	0.70
TLR4	expresses	gene	0.70
MICROGLIA	causes	cell_type	0.70
GPX4	activates	gene	0.70
HIF1A	activates	gene	0.70
GPX4	biomarker_for	gene	0.70
NLRP3	mediates	gene	0.70
VEGF	activates	gene	0.70
TFEB	activates	gene	0.70
SQSTM1	activates	gene	0.70
ULK1	activates	gene	0.70
RIPK1	interacts_with	gene	0.70
NECROPTOSIS	interacts_with	pathway	0.70
XIAP	activates	gene	0.70
GFAP	biomarker_for	gene	0.70
NFKB	activates	gene	0.70
NLRP3	biomarker_for	gene	0.70
Tumor	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Als	associated_with	disease	0.65
Neurodegeneration	regulates	disease	0.65
Ms	activates	disease	0.65
Atherosclerosis	regulates	disease	0.65
Tumor	regulates	disease	0.65
Cancer	regulates	disease	0.65
Pyroptosis	causes	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Ferroptosis	biomarker_for	disease	0.65
Sepsis	therapeutic_target	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Als	causes	disease	0.65
Frontotemporal Dementia	activates	disease	0.65
Infection	regulates	disease	0.65
Stroke	regulates	disease	0.65
ALS	associated_with	disease	0.65
Cancer	inhibits	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Alzheimer	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Als	regulates	disease	0.65
Inflammation	inhibits	disease	0.65
Als	activates	disease	0.65
Huntington	activates	disease	0.65
Inflammation	regulates	disease	0.65

Incoming (256)

Source	Relation	Type	Str
BHB	inhibits	compound	0.80
CREB	biomarker_for	gene	0.70
ENDOTHELIAL	inhibits	cell_type	0.70
CGAS	activates	gene	0.70
BDNF	biomarker_for	gene	0.70
CXCL10	activates	gene	0.70
ENDOTHELIAL	activates	cell_type	0.70
CREB	activates	gene	0.70
BDNF	activates	gene	0.70
BECN1	activates	gene	0.70
ATG5	activates	gene	0.70
AMPK	activates	gene	0.70
DBH	activates	gene	0.70
INFLAMMATION	regulates	gene	0.60
INFLAMMATION	activates	gene	0.60
ALZHEIMER	regulates	gene	0.60
GSDME	activates	gene	0.60
GSDMD	regulates	gene	0.60
PYROPTOSIS	activates	gene	0.60
OVERVIEW	regulates	gene	0.60
MITOCHONDRIA	regulates	gene	0.60
CYTOKINES	regulates	gene	0.60
CANCER	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
NLRP3	regulates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
AMYLOID	activates	gene	0.60
CANCER	regulates	gene	0.60
OVERVIEW	activates	gene	0.60
HMGB1	regulates	gene	0.60
DNA	activates	gene	0.60
ZBP1	activates	gene	0.60
MITOCHONDRIA	activates	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
ASTROCYTES	activates	gene	0.60
AND	regulates	gene	0.60
PARKINSON	causes	gene	0.60
CANCER	therapeutic_target	gene	0.60
NEUROINFLAMMATION	causes	gene	0.60
PARKINSON'S DISEASE	causes	gene	0.60
GENES	regulates	gene	0.60
LRRK2	regulates	gene	0.60
UBIQUITIN	regulates	gene	0.60
VPS35	regulates	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
DNA	regulates	gene	0.60
CGAS	regulates	gene	0.60
LYSOSOME	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GASDERMIN in their description or question text

No additional research found