concept

METFORMIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about METFORMIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

573Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	METFORMIN
Key Genes/Proteins	ACSL4, AKT, AMPK, AMYLOID, AMYLOID-BETA
Related Diseases	ACETYLCHOLINE, aging, AGING, ALS, ALZHEIMER
Related Pathways	AMPK PATHWAY

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Metformin for Parkinson's Disease - Phase 2/3 Trial (NCT07229651)

clinical · 1298 words

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Pathway Diagram

graph TD
    METFORMIN["METFORMIN"]
    style METFORMIN fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    METFORMIN -->|"upregulates"| SIRT1([SIRT1])
    METFORMIN -->|"treats"| Hepatic_Steatosis["Hepatic Steatosis"]
    METFORMIN -->|"activates"| SIRT1_Mediated_Autophagy["SIRT1-Mediated Autophagy"]
    METFORMIN -->|"treats"| Cognitive_Impairment(Cognitive Impairment)
    METFORMIN -->|"activates"| AMPK([AMPK])
    METFORMIN -.->|"inhibits"| astrocyte_senescence["astrocyte senescence"]
    METFORMIN -->|"modulates"| Mitochondrial_Biogenesis["Mitochondrial Biogenesis"]
    METFORMIN -->|"modulates"| Mitochondrial_Dynamics["Mitochondrial Dynamics"]
    METFORMIN -.->|"protects against"| Hippocampal_Neurodegeneration["Hippocampal Neurodegeneration"]

Outgoing (376)

Target	Relation	Type	Str
SIRT1	upregulates	gene	0.95
Necroptosis	suppresses	process	0.95
Hepatic Steatosis	treats	disease	0.95
Mitochondrial Bioenergetics	associated_with	process	0.95
SIRT1-Mediated Autophagy	activates	pathway	0.95
Redox Homeostasis	associated_with	process	0.95
Mitochondrial Respiratory Activity	associated_with	process	0.95
astrocyte senescence	inhibits	process	0.95
AMPK	activates	protein	0.95
Cognitive Impairment	treats	phenotype	0.95
PRKAA1	activates	gene	0.95
Ribociclib-Induced Toxicity	treats	phenotype	0.95
Autophagy	associated_with	process	0.95
Cadmium Neurotoxicity	treats	disease	0.93
Pro-Inflammatory Pathways	associated_with	pathway	0.92
Immune-Inflammatory Responses	modulates	process	0.90
MCOLN1	downregulates	gene	0.90
pro-inflammatory pathways	associated_with	pathway	0.90
Cognitive Impairment	protects_against	phenotype	0.90
Hyperglycemia	treats	disease	0.90
Hippocampal Neurodegeneration	protects_against	process	0.90
PRKAA1/2	activates	gene	0.90
Glucose Homeostasis	associated_with	phenotype	0.90
oxidative stress	associated_with	process	0.90
Mitochondrial Biogenesis	modulates	process	0.90
Glucose Homeostasis	regulates	process	0.90
Mitochondrial Dynamics	modulates	process	0.90
MCOLN1	suppresses	gene	0.90
Insulin Resistance	associated_with	phenotype	0.90
Type 2 Diabetes	treats	disease	0.90
Insulin Resistance	treats	disease	0.90
mitochondrial function	regulates	process	0.90
insulin sensitivity	treats	phenotype	0.90
Pruritus	treats	phenotype	0.90
KRTAP	upregulates	gene	0.90
Type 2 Diabetes	treats	disease	0.90
Neuroinflammation	modulates	process	0.88
Mitochondrial Function	modulates	process	0.88
dopamine neuron injury	prevents	phenotype	0.88
RIPK1	inhibits	gene	0.88
KRTAPS	upregulates	gene	0.88
Oxidative Stress	associated_with	phenotype	0.87
AMPK	upregulates	protein	0.85
ATP Levels	associated_with	biomarker	0.85
Membrane Potential	associated_with	phenotype	0.85
ATP levels	upregulates	phenotype	0.85
Epithelial-Mesenchymal Transition	inhibits	pathway	0.85
Parkinson's Disease	treats	disease	0.85
CA1 Pyramidal Neurons	protects_against	cell_type	0.85
Inflammation	inhibits	process	0.85

Incoming (197)

Source	Relation	Type	Str
PRKAA2	therapeutic_target	gene	0.90
PRKAA1	therapeutic_target	gene	0.90
AMPK	targets	gene	0.70
SYK	regulates	gene	0.65
OXIDATIVE STRESS	regulates	phenotype	0.65
TNF	inhibits	gene	0.65
COGNITIVE DECLINE	activates	phenotype	0.65
CCL2	inhibits	gene	0.65
CYTOKINES	inhibits	phenotype	0.65
AKT	regulates	gene	0.65
NICOTINAMIDE	activates	drug	0.65
NICOTINAMIDE	treats	drug	0.65
NEURONS	treats	cell_type	0.65
TREM2	protects_against	gene	0.65
MLKL	activates	gene	0.65
AMYLOID PLAQUES	protects_against	phenotype	0.65
MLKL	inhibits	gene	0.65
PARKINSON'S DISEASE	targets	disease	0.65
CGAS	mediates	gene	0.65
AMPK	treats	gene	0.65
ENDOTHELIAL	causes	cell_type	0.65
CA1	protects_against	brain_region	0.65
GFAP	protects_against	gene	0.65
ALZHEIMER	treats	disease	0.65
ALZHEIMER'S DISEASE	treats	disease	0.65
DIABETES	treats	disease	0.65
HEPATOCYTES	treats	cell_type	0.65
TH	causes	gene	0.65
BDNF	associated_with	gene	0.65
DIABETES	associated_with	disease	0.65
DIABETES	targets	disease	0.65
AMPK	associated_with	gene	0.55
AMPK	participates_in	gene	0.55
PARKINSON'S DISEASE	participates_in	disease	0.55
ALZHEIMER'S	associated_with	concept	0.50
NEUROBLASTOMA	associated_with	disease	0.50
ALZHEIMER	associated_with	gene	0.50
SUBSTANTIA NIGRA	associated_with	brain_region	0.50
Alzheimer'S Disease	associated_with	disease	0.50
LUNG CANCER	associated_with	disease	0.50
CHOLESTEROL	associated_with	phenotype	0.50
SYNAPTIC PLASTICITY	associated_with	phenotype	0.50
ASTROCYTES	associated_with	cell_type	0.50
SENESCENCE	associated_with	phenotype	0.50
DOPAMINERGIC NEURONS	associated_with	cell_type	0.50
HIPPOCAMPUS	associated_with	brain_region	0.50
Autophagy	decreases_risk	process	0.50
Neuroinflammation	inhibits	process	0.50
Migraine	inhibits	disease	0.50
Neuroinflammation	regulates	process	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning METFORMIN in their description or question text

No additional research found