gene

AIF

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AIF: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

233Connections

2Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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🧬 Gene Info

Gene Symbol	AIF
Chromosome	Xq26.1
Protein Type	Gene
Function	AIF is required for the proper assembly and stability of Complex I, the largest enzyme complex in the electron transport chain.[@ghezzi2010][@klein2002] AIF-deficient cells show 50–70% reduction in Co
Molecular Weight	67 kDa
Pathways	Apoptosis, Ferroptosis, Inflammasome, Necroptosis, Oxidative Stress
GeneCards	AIF
Human Protein Atlas	AIF
FAD-binding domain	Binds flavin adenine dinucleotide (FAD) as a cofactor, conferring NADH oxidase activity essential for mitochondrial respiratory chain function.[@mate2002]
NADH-binding domain	Catalyzes NADH-dependent electron transfer. The oxidoreductase activity is critical for proper assembly and maintenance of Complex I (NADH:ubiquinone oxidoreductase).[@mate2002][@ghezzi2010]
Associated Diseases	ALS, Alzheimer, Inflammation, Ms, Neurodegeneration, Neuroinflammation
Interactions	AKT, ALS, ALZHEIMER, ALZHEIMER'S DISEASE, AMPK, AMYOTROPHIC LATERAL SCLEROSIS
KG Connections	233 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (8)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    AIF["AIF"] -->|"mediates"| Parthanatos["Parthanatos"]
    style Parthanatos fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    AIF["AIF"] -->|"regulates"| Apoptosis["Apoptosis"]
    style Apoptosis fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    AIF["AIF"] -->|"causes"| MITOCHONDRIAL_DYSFUNCTION["MITOCHONDRIAL DYSFUNCTION"]
    style MITOCHONDRIAL_DYSFUNCTION fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    AIF["AIF"] -->|"regulates"| Ms["Ms"]
    style Ms fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    AIF["AIF"] -->|"regulates"| Stroke["Stroke"]
    style Stroke fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    AIF["AIF"] -->|"regulates"| Neurodegeneration["Neurodegeneration"]
    style Neurodegeneration fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    AIF["AIF"] -->|"regulates"| Parkinson["Parkinson"]
    style Parkinson fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    APOPTOSIS["APOPTOSIS"] -->|"activates"| AIF["AIF"]
    style APOPTOSIS fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    NEURODEGENERATION["NEURODEGENERATION"] -->|"regulates"| AIF["AIF"]
    style NEURODEGENERATION fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    E2F1["E2F1"] -->|"regulates"| AIF["AIF"]
    style E2F1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    P53["P53"] -->|"regulates"| AIF["AIF"]
    style P53 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    MYC["MYC"] -->|"regulates"| AIF["AIF"]
    style MYC fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style AIF fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (169)

Target	Relation	Type	Str
Parthanatos	involved_in	pathway	0.90
Parthanatos	mediates	pathway	0.90
PARthanatos	activates	biological_process	0.80
MITOCHONDRIAL DYSFUNCTION	causes	gene	0.70
Apoptosis	regulates	pathway	0.70
Apoptosis	activates	pathway	0.70
neurons	expressed_in	cell_type	0.70
Alzheimer	therapeutic_target	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Neurodegeneration	causes	disease	0.65
Neuroinflammation	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Parkinson	regulates	disease	0.65
Ms	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Stroke	therapeutic_target	disease	0.65
Neuroinflammation	therapeutic_target	disease	0.65
Alzheimer	inhibits	disease	0.65
Huntington	inhibits	disease	0.65
Neuroinflammation	inhibits	disease	0.65
Amyotrophic Lateral Sclerosis	inhibits	disease	0.65
Parkinson	inhibits	disease	0.65
Stroke	inhibits	disease	0.65
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.65
Inflammation	inhibits	disease	0.65
Huntington	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Alzheimer	activates	disease	0.65
ALS	activates	disease	0.65
Ms	activates	disease	0.65
Inflammation	interacts_with	disease	0.65
Aging	interacts_with	disease	0.65
Neurodegeneration	interacts_with	disease	0.65
Neurodegeneration	implicated_in	disease	0.65
Parkinson	interacts_with	disease	0.65
Stroke	activates	disease	0.65
Als	activates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Ms	regulates	disease	0.65
Neuroinflammation	causes	disease	0.65
Parkinson	causes	disease	0.65
Inflammation	causes	disease	0.65
Ms	causes	disease	0.65
Stroke	regulates	disease	0.65
FERROPTOSIS	regulates	gene	0.60
pyroptosis	participates_in	pathway	0.60
DNA	regulates	gene	0.60
NEUROINFLAMMATION	causes	gene	0.60
Neuron	therapeutic_target	cell_type	0.60
ALZHEIMER	therapeutic_target	gene	0.60

Incoming (64)

Source	Relation	Type	Str
APOPTOSIS	activates	gene	0.70
GSDMD	regulates	gene	0.60
RIPK1	regulates	gene	0.60
MLKL	regulates	gene	0.60
RIPK3	regulates	gene	0.60
NLRP3	regulates	gene	0.60
NEURON	therapeutic_target	gene	0.60
STROKE	therapeutic_target	gene	0.60
HUNTINGTON	inhibits	gene	0.60
ALZHEIMER'S DISEASE	inhibits	gene	0.60
ALZHEIMER	inhibits	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	inhibits	gene	0.60
ALS	inhibits	gene	0.60
NEURON	inhibits	gene	0.60
HUNTINGTON'S DISEASE	inhibits	gene	0.60
STROKE	inhibits	gene	0.60
ALS	therapeutic_target	gene	0.60
HUNTINGTON	therapeutic_target	gene	0.60
PARKINSON	therapeutic_target	gene	0.60
E2F1	regulates	gene	0.60
MYC	regulates	gene	0.60
DIABLO	regulates	gene	0.60
EGF	regulates	gene	0.60
ERK1	regulates	gene	0.60
MDM2	regulates	gene	0.60
RAF1	regulates	gene	0.60
P38	regulates	gene	0.60
DYRK1A	regulates	gene	0.60
SMAC	regulates	gene	0.60
ATG5	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
APOPTOSIS	associated_with	gene	0.60
PARKINSON'S DISEASE	regulates	gene	0.60
PYROPTOSIS	regulates	gene	0.60
OXIDATIVE STRESS	regulates	gene	0.60
FERROPTOSIS	regulates	gene	0.60
MITOCHONDRIAL DYSFUNCTION	regulates	gene	0.60
NEUROINFLAMMATION	regulates	gene	0.60
BDNF	activates	gene	0.60
BAX	activates	gene	0.60
ROS	regulates	gene	0.60
PARKINSON	causes	gene	0.60
NEUROINFLAMMATION	causes	gene	0.60
PARKINSON'S DISEASE	causes	gene	0.60
GASDERMIN	regulates	gene	0.60
DNA	regulates	gene	0.60
OXIDATIVE STRESS	causes	gene	0.60
AND	regulates	gene	0.60
MITOCHONDRIAL DYSFUNCTION	causes	gene	0.60
NEUROINFLAMMATION	inhibits	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
PARP1-NAD+-AIF bioenergetic collapse drives a self-amplifyin	0.760	neurodegeneration	What mechanisms drive the self-amplifyin
Epigenetic Silencing of AIF1 Gene Locus by Chronic Inflammat	0.643	neuroinflammation	What causes IBA1 low/negative microglia

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning AIF in their description or question text

No additional research found

AIF

Understanding Entity Pages

Wiki Pages (8)

AIF Gene

AIFM1 Gene

AIFM2 — Apoptosis-Inducing Factor Mitochondria-Like 2

AIF1 Gene

AIFM3 — Apoptosis-Inducing Factor Mitochondria 3

FSP1/AIFM2 (Ferroptosis Suppressor Protein 1)

AIFM1 Protein — Apoptosis-Inducing Factor

AIF Protein