protein
UBIQUITIN
Entity Detail — Knowledge Graph Node
Understanding Entity Pages
This page aggregates everything SciDEX knows about UBIQUITIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
4042Connections
10Hypotheses
0Analyses
50Outgoing
50Incoming
1Experiments
0Debates
Summary
UBIQUITIN is a protein involved in neurodegeneration research. Key relationships include: activates, associated with, regulates. Associated with ALS, AMYOTROPHIC LATERAL SCLEROSIS, Aging. Connected to 2278 entities in the SciDEX knowledge graph.
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Protein Info
| Gene Symbol | UBIQUITIN |
| Function | is a highly conserved 76-amino acid protein that covalently attaches to target proteins to mark them for various cellular fates. |
| Pathways | Adaptive Immunity, Akt, Angiogenesis, Apoptosis, Autophagy |
| GeneCards | UBIQUITIN |
| Human Protein Atlas | UBIQUITIN |
| 19S Regulatory Cap | Recognizes polyubiquitinated substrates, removes ubiquitin chains (recycling ubiquitin), unfolds substrates, and translocates them into the core particle |
| 20S Core Particle | Cylindrical proteolytic chamber with three distinct protease activities (beta1, beta2, beta5 subunits) |
| Associated Diseases | Aging, Als, Alzheimer, Alzheimer'S Disease, Amyotrophic Lateral Sclerosis |
| Known Drugs/Compounds | proteolysis-targeting chimeras, RAPAMYCIN |
| Interactions | ABCD3, ABLIM1, ACAT1, ACE, ACETYL-COA, ACOD1 |
| KG Connections | 3814 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Wiki Pages (1)
Knowledge base pages for this entity
Pathway Diagram
graph TD
subgraph Signaling["Signaling"]
UBIQUITIN["UBIQUITIN"] -->|"regulates"| Als["Als"]
UBIQUITIN["UBIQUITIN"] -->|"regulates"| Apoptosis["Apoptosis"]
UBIQUITIN["UBIQUITIN"] -->|"regulates"| Autophagy_1["Autophagy"]
UBIQUITIN["UBIQUITIN"] -->|"activates"| Oxidative_Stress["Oxidative Stress"]
UBIQUITIN["UBIQUITIN"] -->|"regulates"| Proteasome["Proteasome"]
UBIQUITIN["UBIQUITIN"] -->|"regulates"| Ubiquitin_Proteasome["Ubiquitin-Proteasome"]
UBIQUITIN["UBIQUITIN"] -->|"activates"| Als_2["Als"]
UBIQUITIN["UBIQUITIN"] -->|"activates"| Cancer["Cancer"]
OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"activates"| UBIQUITIN["UBIQUITIN"]
TLR4["TLR4"] -->|"activates"| UBIQUITIN["UBIQUITIN"]
NEURODEGENERATION["NEURODEGENERATION"] -->|"regulates"| UBIQUITIN["UBIQUITIN"]
end
subgraph Interactions["Interactions"]
UBIQUITIN["UBIQUITIN"] -->|"interacts with"| Autophagy["Autophagy"]
end
subgraph Pathology["Pathology"]
AUTOPHAGY["AUTOPHAGY"] -->|"associated with"| UBIQUITIN["UBIQUITIN"]
end
subgraph Therapeutic["Therapeutic"]
PARKINSON_S_DISEASE["PARKINSON'S DISEASE"] -->|"therapeutic target"| UBIQUITIN["UBIQUITIN"]
NEURODEGENERATION_3["NEURODEGENERATION"] -->|"therapeutic target"| UBIQUITIN["UBIQUITIN"]
end
style UBIQUITIN fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0,font-weight:bold
style Als fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Apoptosis fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Autophagy fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Autophagy_1 fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Oxidative_Stress fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Proteasome fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Ubiquitin_Proteasome fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Als_2 fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Cancer fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style OXIDATIVE_STRESS fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style TLR4 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style AUTOPHAGY fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style PARKINSON_S_DISEASE fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style NEURODEGENERATION fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style NEURODEGENERATION_3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0Outgoing (2129)
| Target | Relation | Type | Str |
|---|---|---|---|
| Als | inhibits | disease | 1.00 |
| Neurodegeneration | associated_with | disease | 1.00 |
| Autophagy | interacts_with | pathway | 1.00 |
| Apoptosis | regulates | pathway | 1.00 |
| CANCER | therapeutic_target | gene | 1.00 |
| Ubiquitin-Proteasome | associated_with | pathway | 1.00 |
| Oxidative Stress | activates | pathway | 1.00 |
| Als | interacts_with | disease | 1.00 |
| PARKIN | associated_with | gene | 1.00 |
| Proteasome | activates | pathway | 1.00 |
| Proteasome | regulates | pathway | 1.00 |
| DNA | regulates | gene | 1.00 |
| Ubiquitin-Proteasome | activates | pathway | 1.00 |
| Autophagy | associated_with | pathway | 1.00 |
| Als | regulates | disease | 1.00 |
| Ubiquitin-Proteasome | regulates | pathway | 1.00 |
| Neurodegeneration | activates | disease | 1.00 |
| Alzheimer | associated_with | disease | 1.00 |
| PARKIN | activates | gene | 1.00 |
| Aging | activates | disease | 1.00 |
| Cancer | inhibits | disease | 1.00 |
| Cell Cycle | regulates | pathway | 1.00 |
| Autophagy | therapeutic_target | pathway | 1.00 |
| Proteasome | inhibits | pathway | 1.00 |
| MITOCHONDRIA | activates | gene | 1.00 |
| Tumor | therapeutic_target | disease | 1.00 |
| Parkinson | activates | disease | 1.00 |
| CANCER | regulates | gene | 1.00 |
| Infection | activates | disease | 1.00 |
| Aging | associated_with | disease | 1.00 |
| Cancer | therapeutic_target | disease | 1.00 |
| Mitophagy | activates | pathway | 1.00 |
| Proteasome | associated_with | pathway | 1.00 |
| Tumor | regulates | disease | 1.00 |
| Carcinoma | activates | disease | 1.00 |
| Tumor | inhibits | disease | 1.00 |
| Autophagy | activates | pathway | 1.00 |
| Cancer | regulates | disease | 1.00 |
| Nf-Κb | activates | pathway | 1.00 |
| Als | associated_with | disease | 1.00 |
| Parkinson | associated_with | disease | 1.00 |
| Mitophagy | regulates | pathway | 1.00 |
| Neurodegeneration | regulates | disease | 1.00 |
| PARKIN | regulates | gene | 1.00 |
| Proteasome | therapeutic_target | pathway | 1.00 |
| Als | therapeutic_target | disease | 1.00 |
| MITOCHONDRIA | regulates | gene | 1.00 |
| Cancer | activates | disease | 1.00 |
| Als | activates | disease | 1.00 |
| Tumor | activates | disease | 1.00 |
Incoming (1913)
| Source | Relation | Type | Str |
|---|---|---|---|
| PARKINSON | activates | gene | 1.00 |
| NEURODEGENERATION | associated_with | gene | 1.00 |
| PARKINSON'S DISEASE | associated_with | gene | 1.00 |
| PARKINSON | associated_with | gene | 1.00 |
| NLRP3 | activates | gene | 1.00 |
| MITOPHAGY | associated_with | gene | 1.00 |
| GENES | activates | gene | 1.00 |
| NEURODEGENERATION | regulates | gene | 1.00 |
| PARKINSON'S DISEASE | therapeutic_target | gene | 1.00 |
| ALZHEIMER | associated_with | gene | 1.00 |
| ALZHEIMER'S DISEASE | associated_with | gene | 1.00 |
| CANCER | regulates | gene | 1.00 |
| NEURODEGENERATION | therapeutic_target | gene | 1.00 |
| PINK1 | regulates | gene | 1.00 |
| KEAP1 | interacts_with | gene | 1.00 |
| INFLAMMATION | regulates | gene | 1.00 |
| OXIDATIVE STRESS | activates | gene | 1.00 |
| TLR4 | activates | gene | 1.00 |
| AUTOPHAGY | activates | gene | 1.00 |
| NEURODEGENERATION | activates | gene | 1.00 |
| CANCER | activates | gene | 1.00 |
| AUTOPHAGY | associated_with | gene | 1.00 |
| NF-ΚB | activates | gene | 1.00 |
| INFLAMMATION | activates | gene | 1.00 |
| LYSOSOME | activates | gene | 1.00 |
| PARKINSON | therapeutic_target | gene | 1.00 |
| PINK1 | inhibits | gene | 1.00 |
| MITOPHAGY | inhibits | gene | 1.00 |
| LYSOSOME | regulates | gene | 1.00 |
| OXIDATIVE STRESS | regulates | gene | 1.00 |
| CANCER | inhibits | gene | 1.00 |
| APOPTOSIS | regulates | gene | 1.00 |
| GENES | regulates | gene | 1.00 |
| P62 | regulates | gene | 1.00 |
| AUTOPHAGY | therapeutic_target | gene | 1.00 |
| AUTOPHAGY | regulates | gene | 0.98 |
| PINK1 | activates | gene | 0.98 |
| TAU | associated_with | gene | 0.98 |
| P62 | associated_with | gene | 0.98 |
| E1, E2, E3 enzymes | modulates | protein | 0.95 |
| E3 Ubiquitin Ligases | mediates | enzyme | 0.95 |
| USP9X | associated_with | gene | 0.95 |
| DUB | cleaves | enzyme | 0.95 |
| OTUD6A | degrades | gene | 0.95 |
| FBXL7 | mediates | protein | 0.95 |
| OPTN | associated_with | entity | 0.95 |
| USP10 | removes | protein | 0.95 |
| UBQLN2 | interacts_with | protein | 0.95 |
| NEDD4L | interacts_with | protein | 0.92 |
| ANLN | modified_by | protein | 0.92 |
Targeting Hypotheses (10)
Hypotheses where this entity is a therapeutic target
Mentioning Analyses (0)
Scientific analyses that reference this entity
No analyses mention this entity
Experiments (1)
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| TRIM21 E3 ubiquitin ligase screen for stress granule regulation | exploratory | neurodegenerative diseases | 0.900 | 0.00 | cultured cells | proposed | N/A |
Related Papers (20)
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Stress granule homeostasis is modulated by TRIM21-mediated ubiquitination of G3B [PMID:36692217] | Yang C, Wang Z, Kang Y, Yi Q, Wang T, Ba | Autophagy | 2023 | 3 |
| Rsp5/NEDD4 and ESCRT regulate TDP-43 toxicity and turnover via an endolysosomal [PMID:41498748] | Unknown | The Journal of cell biology | 2026 | 0 |
| Rsp5/NEDD4 and ESCRT regulate TDP-43 toxicity and turnover via an endolysosomal [PMID:41498748] | Byrd, Marmorale, Marcinowski, Dykstra, A | The Journal of cell biology | 2026 | 0 |
| Proof of concept: targeted protein degradation of the stress granules component [PMID:41586493] | Unknown | Antimicrobial agents and chemo | 2026 | 0 |
| Stress granules: Guardians of cellular health and triggers of disease. [PMID:39995077] | ["Desai M", "Gulati K", "Agrawal M", "Gh | Neural regeneration research | 2026 | 0 |
| Implications of virus-induced stress granules in tauopathies. [PMID:41673769] | Sharma S, Vandenakker A, Cortés-Pérez C, | Translational neurodegeneratio | 2026 | 0 |
| Stress granules: Guardians of cellular health and triggers of disease. [PMID:39995077] | Desai M, Gulati K, Agrawal M, Ghumra S, | Neural Regen Res | 2026 | 0 |
| Uridine analogs prevent stress granule formation, not by blocking PKR recognitio [PMID:41571440] | Ihn SJ, Jiang E, Kejiou NS, Wang YE, Far | RNA | 2026 | 0 |
| Proof of concept: targeted protein degradation of the stress granules component [PMID:41586493] | Echavarria-Consuegra L, Goodfellow I | Antimicrob Agents Chemother | 2026 | 0 |
| Atg5/Autophagy inactivation in mouse bone microenvironment promotes tumor develo [PMID:41612597] | Trojani MC, Nollet M, Camuzard O, Santuc | Autophagy | 2026 | 0 |
| High expression of G3BP1 is associated with poor prognosis in breast invasive ca [PMID:41635545] | Li J, Zong Z, Shen J, Wang J, Zhou X et | Oncol Lett | 2026 | 0 |
| Implications of virus-induced stress granules in tauopathies. [PMID:41673769] | Sharma S, Vandenakker A, Cortés-Pérez C, | Transl Neurodegener | 2026 | 0 |
| Dysregulated miRNAs and downstream gene expression associated with poor treatmen [PMID:41694232] | Yu SC, Wang YC, Lin HP, Jen YW, Hwang TJ | Brain Behav Immun Health | 2026 | 0 |
| Pharmacological modulation of stress granules via G3BP1/2: A pathway to treat ca [PMID:41924133] | Yang J, Gao F | Front Pharmacol | 2026 | 0 |
| Stress granules at the crossroads of retroviral replication and antiviral immuni [PMID:41931190] | Akbarin MM, Farjami Z, Álvarez HR | Mol Biol Rep | 2026 | 0 |
| Targeting G3BP1-Mediated Stress Granules to Suppress SARS-CoV-2 Replication. [PMID:41960678] | Aromokeye R, Kuang L, Ackerman-Berrier M | ACS Infect Dis | 2026 | 0 |
| The neuroprotective effect of Cucurbitacin B against Aβ and tau toxicities requi [PMID:42012542] | Tu X, Fang M, Yan Y, Liu Y, Yu J et al. | Biogerontology | 2026 | 0 |
| Pharmacological modulation of stress granules via G3BP1/2: A pathway to treat ca [PMID:41924133] | Yang J, Gao F | Frontiers in pharmacology | 2026 | 0 |
| Upregulation of NF-κB by USP24 aggravates ferroptosis in diabetic cardiomyopathy [PMID:38056575] | Wu S, Zhou Y, Liang J | Free Radic Biol Med | 2024 | 0 |
| Ripks and Neuroinflammation. [PMID:38349514] | Xu Y, Lin F, Liao G, Sun J, Chen W, Zhan | Molecular neurobiology | 2024 | 0 |
Debates (0)
Multi-agent debates referencing this entity
No debates reference this entity
Related Research
Hypotheses and analyses mentioning UBIQUITIN in their description or question text
TRIM21-Mediated Ubiquitination Creates Peripheral Epitope Gradient via K63-Linke
Score: 0.548 · neurodegeneration · 2026-04-21
## Mechanistic Overview TRIM21-Mediated Ubiquitination Creates Peripheral Epitope Gradient via K63-Linked Chain Accumula
CHIP-mediated K63-linked ubiquitination redirects oligomeric pathologic conforme
Score: 0.380 · protein biochemistry · 2026-04-27
**Molecular Mechanism and Rationale** The carboxy terminus of Hsc70-interacting protein (CHIP, encoded by STUB1) functi
CHIP-mediated K63-linked ubiquitination promotes autophagosomal sequestration of
Score: 0.380 · protein biochemistry · 2026-04-27
The carboxy terminus of Hsc70-interacting protein (CHIP, encoded by STUB1) functions as a dual-specificity E3 ubiquitin
Exposed amyloidogenic segments trigger CHIP-mediated oligomer-selective ubiquiti
Score: 0.380 · protein biochemistry · 2026-04-27
This hypothesis proposes that HSP70's recognition of exposed β-sheet propensity sequences in amyloidogenic proteins serv
K48/K63 ubiquitin chain balance separates causal from compensatory states in: Ho
Score: 0.335 · neurodegeneration · 2026-04-26
A longitudinal biomarker panel centered on K48/K63 ubiquitin chain balance can distinguish harmful mechanisms from prote