disease

AUTISM

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AUTISM: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

890Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

No summary available yet.

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Disease Info

Associated Genes	CLOCK, MTNR1A, MTNR1B, PVALB, REELIN, SST
Therapeutic Agents	MELATONIN
KG Connections	244 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Cerebellar Golgi Cells in Autism Spectrum Disorder

cell · 1040 words

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Pathway Diagram

graph TD
    AUTISM["AUTISM"] -->|"expressed in"| BDNF["BDNF"]
    style BDNF fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    AUTISM["AUTISM"] -->|"expressed in"| WNT["WNT"]
    style WNT fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    AUTISM["AUTISM"] -->|"regulates"| LEWY_BODY["LEWY BODY"]
    style LEWY_BODY fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    AUTISM["AUTISM"] -->|"causes"| MICROGLIA["MICROGLIA"]
    style MICROGLIA fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    AUTISM["AUTISM"] -->|"causes"| SYNAPTIC_PLASTICITY["SYNAPTIC PLASTICITY"]
    style SYNAPTIC_PLASTICITY fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
    AUTISM["AUTISM"] -->|"associated"| MITOCHONDRIAL_DYSFUNCTION["MITOCHONDRIAL DYSFUNCTION"]
    style MITOCHONDRIAL_DYSFUNCTION fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
    AUTISM["AUTISM"] -->|"interacts"| DEPRESSION["DEPRESSION"]
    style DEPRESSION fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    RELN["RELN"] -->|"implicated in"| AUTISM["AUTISM"]
    style RELN fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    ALZHEIMER_S["ALZHEIMER'S"] -->|"associated"| AUTISM["AUTISM"]
    style ALZHEIMER_S fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    REELIN["REELIN"] -->|"interacts"| AUTISM["AUTISM"]
    style REELIN fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    ALS["ALS"] -->|"associated"| AUTISM["AUTISM"]
    style ALS fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    ALZHEIMER["ALZHEIMER"] -->|"co discussed"| AUTISM["AUTISM"]
    style ALZHEIMER fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    style AUTISM fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (361)

Target	Relation	Type	Str
Inflammation	associated_with	disease	0.95
pyroptosis	involves	pathway	0.90
neurons	affects	cell_type	0.90
cortex	affects	brain_region	0.80
axon	disrupts	organelle	0.80
interneurons	affects	cell_type	0.80
Schizophrenia	associated_with	disease	0.75
Neuroinflammation	associated_with	disease	0.75
Als	interacts_with	disease	0.75
astrocytes	affects	cell_type	0.70
Mtor	interacts_with	pathway	0.70
temporal lobe	affects	brain_region	0.70
necroptosis	involves	pathway	0.70
Autophagy	activates	pathway	0.70
Mtor	associated_with	pathway	0.70
Synaptic Plasticity	associated_with	pathway	0.70
microglia	affects	cell_type	0.70
neural stem cells	affects	cell_type	0.70
TAU	promotes	gene	0.65
TAU	protects_against	gene	0.65
NEURONS	expressed_in	cell_type	0.65
NEURON	expressed_in	cell_type	0.65
INTERNEURON	expressed_in	cell_type	0.65
NEURONS	associated_with	cell_type	0.65
WNT	expressed_in	gene	0.65
SIRT1	activates	gene	0.65
Depression	associated_with	disease	0.65
Als	activates	disease	0.65
BDNF	expressed_in	gene	0.65
LEWY BODY DISEASE	regulates	disease	0.65
TRAUMATIC BRAIN INJURY	associated_with	disease	0.65
LEWY BODY	regulates	disease	0.65
Als	associated_with	disease	0.65
ferroptosis	involves	pathway	0.60
striatum	affects	brain_region	0.60
Mtor	inhibits	pathway	0.60
Synaptic Plasticity	activates	pathway	0.60
synaptic vesicle	disrupts	organelle	0.60
cerebellum	affects	brain_region	0.60
Neurogenesis	activates	pathway	0.60
neuropeptide Y	disrupts	neurotransmitter	0.60
Circadian Rhythm	contributes_to	pathway	0.60
oxytocin	disrupts	neurotransmitter	0.60
frontal lobe	affects	brain_region	0.60
prefrontal cortex	affects	brain_region	0.60
macrophages	affects	cell_type	0.60
SYN1	causes	gene	0.60
EPILEPSY	causes	disease	0.60
GBA	associated_with	gene	0.60
Autophagy	interacts_with	pathway	0.60

Incoming (529)

Source	Relation	Type	Str
INFLAMMATION	associated_with	gene	0.85
MICROGLIA	associated_with	gene	0.85
MICROGLIA	activates	gene	0.85
RLN	associated_with	protein	0.85
RELN	implicated_in	entity	0.85
NEUROINFLAMMATION	associated_with	gene	0.85
ROS	activates	gene	0.80
NLRP3	regulates	gene	0.80
NLRP3	activates	gene	0.80
MTOR Inhibitors	treats	drug	0.80
Reelin Signaling Pathway	associated_with	pathway	0.80
Microbiota	associated_with	process	0.80
GSDMD	regulates	gene	0.80
GSDMD	activates	gene	0.80
REELIN	implicated_in	protein	0.80
Serotonin	associated_with	compound	0.80
GSDMD	inhibits	gene	0.80
ANXIETY	associated_with	gene	0.75
GENES	interacts_with	gene	0.75
Microglia	associated_with	cell_type	0.75
CYTOKINES	activates	gene	0.75
OXIDATIVE STRESS	therapeutic_target	gene	0.75
AUTOPHAGY	activates	gene	0.75
OXIDATIVE STRESS	associated_with	gene	0.75
ALZHEIMER'S DISEASE	interacts_with	disease	0.75
MITOCHONDRIAL DYSFUNCTION	associated_with	gene	0.75
DEPRESSION	associated_with	gene	0.75
MITOCHONDRIA	associated_with	gene	0.75
OXIDATIVE STRESS	activates	gene	0.75
MTOR	interacts_with	gene	0.75
TSC2	interacts_with	gene	0.75
MTOR	associated_with	gene	0.75
TSC1	interacts_with	gene	0.75
NLRP3	inhibits	gene	0.70
ROS	inhibits	gene	0.70
NLRP3	degrades	gene	0.70
valproic acid	treats	compound	0.70
NLRP3	associated_with	gene	0.70
GSDMD	degrades	gene	0.70
ALS	associated_with	gene	0.65
NLRP3	associated_with	gene	0.65
ATP	associated_with	gene	0.65
ASC	activates	gene	0.65
HDAC2	expressed_in	gene	0.65
DNA	associated_with	gene	0.65
MTDNA	associated_with	gene	0.65
ALZHEIMER	activates	gene	0.65
DNA	interacts_with	gene	0.65
AUTOPHAGY	expressed_in	gene	0.65
LC3	expressed_in	gene	0.65

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning AUTISM in their description or question text

No additional research found